| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC10763 | Philanthotoxin 74 (hydrochloride) Featured | Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. |
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| DCAPI1588 | Pilsicainide hydrochloride | Pilsicainide hydrochloride is a selective Na+ channel blocker (IC30 values are 9 and 60 μM for inward Na+ and Ca2+ currents respectively). Shows antiarrhythmic effects in vivo. Orally active. |
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| DC12096 | Pinacidil monohydrate (Pinacidil hydrate) Featured | Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator. |
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| DC10113 | Pipequaline Featured | Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity. |
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| DCAPI1330 | Piracetam | Piracetam is a cyclic derivative of the neurotransmitter ã-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders. |
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| DC7588 | PNU120596 Featured | PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM. |
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| DC7483 | PPQ-102 Featured | PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM. |
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| DCAPI1473 | Pregabalin Featured | Pregabalin |
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| DC10224 | Procaine | Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. |
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| DC9636 | Pyr6 | Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells). |
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| DC8307 | QNZ46 Featured | QNZ is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). |
|
| DC10578 | rac BHFF Featured | Rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the efficacy and potency of GABA ( > 149% and > 15-fold respectively). Orally active and exhibits anxiolytic activity in vivo. |
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| DC9513 | Radafaxine (hydrochloride) Featured | Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulat |
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| DC9162 | Ranolazine HCl Featured | Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). |
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| DC8175 | Rapastinel(GLYX-13) Featured | Rapastinel(GLYX-13) is a NMDA receptor partial agonist that acts at the glycine site. |
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| DC8807 | Retigabine dihydrochloride Featured | Retigabine 2Hcl (Ezogabine; D23129) is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity. |
|
| DC11325 | RN-1734 Featured | RN-1734 is a transient receptor potential vanilloid 4 (TRPV4) antagonist, blocking calcium influx induced by the TRPV4 agonist 4α-phorbol 12,13-didecanoate with IC50 values of 2.3, 5.9, and 3.2 µM for human, mouse, and rat TRPV4, respectively. |
|
| DC9851 | Ro 25-6981 | Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. |
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| DC9852 | Ro 25-6981 maleate Featured | Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. |
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| DC7490 | Rostafuroxin Featured | Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. |
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| DC8105 | RPR-260243 | RPR260243 was the first reported hERG channel activator. |
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| DC8306 | RQ-00203078 Featured | RQ-00203078 is a potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). |
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| DC11176 | S44819 | S44819 (S 44819, Egis-13529) is a novel potent, competitive, selective antagonist of the α5-GABAAR with Kd of 221 nM, IC50 of 585 nM (α5β2γ2). |
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| DC8099 | Saclofen Featured | Saclofen is a selective GABAB antagonist. |
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| DC9735 | SB-366791 Featured | SB-366791 is a selective and competitive VR1 (TRPV1) antagonist that is commonly used in pain research. |
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| DC9635 | SB-705498 Featured | SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1. |
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| DC9523 | SDZ 220-581 (hydrochloride) | SDZ 220-581 Hcl is a potent, competitive antagonist at the NMDA glutamate receptor subtype(pKi= 7.7). |
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| DC9522 | SDZ 220-581 | SDZ 220-581 is a potent, competitive antagonist at the NMDA glutamate receptor subtype(pKi= 7.7). |
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| DC7536 | YM-90K hydrochloride | Selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM For AMPA, kainate and NMDA receptors respectively). Neuroprotective. |
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| DC9600 | Senicapoc Featured | Senicapoc(ICA17043) is a potent and selective Gardos channel blocker; blocked Ca(2+)-induced rubidium flux from human RBCs/ inhibited RBC dehydration with IC50s of 11 nM/30 nM, respectively. IC50 value: 11/30 nM [1] Target: Gardos channel in vitro: I |
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