| DC7801 |
LB-100
Featured
|
LB-100 is a small-molecular protein phosphatase 2A(PP2A)inhibitor with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. |
|
| DC7707 |
LCZ-696
Featured
|
LCZ696 is a first-in-class dual inhibitor of the angiotensin II receptor(AT II receptor) and neprilysin; a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). |
|
| DC8688 |
Leupeptin hemisulfate
Featured
|
Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor, which has been shown to inhibit cathepsins B, H, L, and S, calpain, and trypsin. Leupeptin hemisulfate is an orally active, antioxidant and anti-inflammatory agent. |
|
| DC1105 |
Linagliptin (BI-1356)
Featured
|
Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM. |
|
| DC9123 |
Lisinopril Dihydrate |
Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks. |
|
| DC10836 |
LMPTP inhibitor 23
Featured
|
LMPTP inhibitor 1 is a potent molecule for diabetes which can increase liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes by inhibiting the IR phosphatase LMPTP. |
|
| DC10665 |
LSN3154567(Nampt-IN-1)
Featured
|
LSN3154567 is a novel inhibitor of NAMPT with IC50 of 18 nM (NCI-H1155 cell), 49 nM (Calu-6 cell), 333 nM (HCC1937 cell), and 389 nM (MCF-7 cell), respectively. |
|
| DC12117 |
Luteolin 7-O-glucuronide (Luteolin 7-glucuronide4)
Featured
|
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively. |
|
| DC12118 |
Luteolin-3-O-beta-D-glucuronide |
Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position. |
|
| DC7456 |
LX1606 Hippurate
Featured
|
LX1606 is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. |
|
| DC2045 |
LY2183240 |
LY2183240 is a novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). |
|
| DC5180 |
LY2811376
Featured
|
LY2811376 is the first orally available non-peptidicβ-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM. |
|
| DC5053 |
LY2886721
Featured
|
LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease. |
|
| DC7526 |
Varespladib
Featured
|
LY315920 (Varespladib) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM,. Phase 3. |
|
| DC8031 |
Marimastat |
Marimastat is a broad spectrum MMP inhibitor and selective TACE inhibitor |
|
| DC11338 |
MMP-2/MMP-7 Fluorogenic Substrate Control
Featured
|
Mca-PL is a fluorogenic peptide that has been used as a building block in the synthesis of Mca-PLGL-Dpa-AR-NH2, a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. |
|
| DC11419 |
Merimepodib
Featured
|
Merimepodib(VX-497) is a novel noncompetitive inhibitor of IMPDH (Inosine monophosphate dehydrogenase). |
|
| DCAPI1146 |
Methoxsalen (Oxsoralen) |
Methoxsalen (Oxsoralen) |
|
| DC9110 |
Mevastatin |
Mevastatin (Compactin; ML236B) inhibits HMGCR (HMG-CoA reductase) (Ki for acid form is 1 nM) which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. |
|
| DC3158 |
Milrinone
Featured
|
Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE |
|
| DC8041 |
MK-0941
Featured
|
MK-0941 is a novel Glucokinase activator (GKA) |
|
| DC7585 |
Omarigliptin
Featured
|
MK-3102 (MSD) is a novel DPP-4 Inhibitor, which improves glycaemic control with low risk of symptomatic hypoglycaemia. |
|
| DC5034 |
MK8245
Featured
|
MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. |
|
| DC9901 |
Verubecestat (MK-8931)
Featured
|
MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase. |
|
| DC9874 |
ML-348(ML348)
Featured
|
ML 348(ML348) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). |
|
| DC10747 |
ML355
Featured
|
ML355 is a potent and selective inhibitors of 12-Lipoxygenase(12-LOX) with IC50 of 0.34 μM, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties. |
|
| DC12255 |
MLN-4760
Featured
|
MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM). |
|
| DC11368 |
MMP-2/MMP-9 Inhibitor II |
MMP-2/MMP-9 inhibitor II is a dual inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 17 and 30 nM, respectively). |
|
| DC11343 |
MMP-2/MMP-9 Inhibitor III |
MMP-2/MMP-9 inhibitor III is a cyclic peptide inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 10-20 μM for both). |
|
| DC11355 |
MMP-3 Inhibitor
Featured
|
MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM. |
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