| DC9326 |
Moexipril (hydrochloride) |
Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure. |
|
| DC7982 |
Mutant IDH1-IN-1
Featured
|
Mutant IDH1-IN-1 is a potent mutant IDH1 R132H inhibitor with IC50 < 0.1 uM(A level in Patent). |
|
| DC7471 |
N6022
Featured
|
N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase(GSNOR) inhibitor(IC50=10 nM) which is currently undergoing clinical development. |
|
| DCAPI1460 |
Naratriptan hydrochloride |
Naratriptan Hydrochloride is a triptan drug which is used for the treatment of migraine headaches. |
|
| DC8857 |
NCT-501 |
NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM. |
|
| DC12128 |
NCT-505
Featured
|
NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM). |
|
| DC10173 |
Firsocostat(ND-630,GS-0976)
Featured
|
ND-630 is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively. |
|
| DC9046 |
Neostigmine bromide |
Neostigmine Bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis. |
|
| DCAPI1543 |
Neostigmine Methylsulfate |
Neostigmine Methyl Sulfate is a reversible acetylcholinesterase inhibitor. This compound blocks the breakdown of acetylcholine in the synaptic space, leading to prolonged signaling and thus increased muscle contractions. |
|
| DC5177 |
Nepicastat HCl (SYN-117)
Featured
|
Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. |
|
| DC8021 |
Indoximod (NLG-8189)
Featured
|
NLG-8189 is an inhibitor of IDO and INDOL1 (IDO2) |
|
| DC9579 |
Nortadalafil
Featured
|
Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
IC50 value:
Ta |
|
| DC9999 |
NQ301
Featured
|
NQ301 is a selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. |
|
| DC7787 |
NS-2028 |
NS 2028 is a specific inhibitor of soluble guanylyl cyclase. |
|
| DC7215 |
NSC 405020
Featured
|
NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP. |
|
| DC6401 |
Odanacatib (MK 0822)
Featured
|
Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of human and rabbit cathepsin K with IC50 of 0.2 nM and 1 nM , respectively. |
|
| DC9583 |
Oglemilast
Featured
|
Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.
|
|
| DC9577 |
Olprinone (Hydrochloride)
Featured
|
Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor. |
|
| DC12281 |
Olutasidenib (FT-2102)
Featured
|
Olutasidenib is a highly potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 that could be used in the treatment of acute myeloid leukemia. |
|
| DC10324 |
Omapatrilat |
Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively. |
|
| DC9443 |
Otamixaban |
Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa.
|
|
| DC10345 |
PDE1-IN-2 |
PDE1-IN-2 is an inhibitor of PDE1 extracted from patent WO2016/55618 A1, example 31; has IC50 values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. |
|
| DC11367 |
PF-04447943
Featured
|
PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis. |
|
| DC7227 |
PF-04620110
Featured
|
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
|
| DC10418 |
PF-04957325 |
PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50 values of 0.7 nM for PDE8A and less than 0.3 nM for PDE8B. |
|
| DC10050 |
PF05175157
Featured
|
PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively. |
|
| DC11937 |
PF 05180999
Featured
|
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM. |
|
| DC10022 |
PF06840003
Featured
|
PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities. |
|
| DC7201 |
PF-2545920(MP-10)
Featured
|
PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM. |
|
| DC7247 |
PF-8380
Featured
|
PF-8380 is a potent and specofic autotaxin inhibitor with an IC50 value of 2.8 nM. |
|
