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Cat. No. Product Name Field of Application Chemical Structure
PR0049567 BTX-7312 Featured BTX-7312 is a cereblon-based SOS1 bifunctional degrader and a molecular glue. BTX-7312 reduces downstream signaling markers pERK and pS6 and shows antiproliferative activity in various KRAS-mutated cells.
DC67344 Pomalidomide-d3 Featured Pomalidomide-d3 is a stable isotope-labeled analog of the clinically important immunomodulatory drug Pomalidomide, where three hydrogen atoms are replaced with deuterium.
DC67345 MMH1-NR Featured MMH1-NR is a purpose-designed negative control compound for the DCAF16-based BRD4 degrader MMH1, featuring a strategically incorporated non-reactive ethyl group that abolishes degradation activity while maintaining structural similarity.
DC67346 Jasmonic acid Featured Jasmonic acid ((-)-Jasmonic acid) is a plant growth regulator and a derivative of α-Linolenic acid (HY-N0728). Jasmonic acid signaling can also induce the MAP kinase cascade pathway, calcium channel, and many processes that interact with signaling molecules.
DC67348 Thalidomide-d4 Featured Thalidomide-d4 is a deuterium-enriched analog of the prototypic immunomodulatory drug thalidomide, featuring four strategically positioned deuterium substitutions. This isotopically labeled compound retains the parent molecule's ability to bind cereblon (CRBN) with high affinity (Kd ≈ 250 nM), thereby modulating the activity of the CUL4-RBX1-DDB1-CRBN E3 ubiquitin ligase complex.
DC67349 Lenalidomide-d5 Featured Lenalidomide-d5 is a deuterium-enriched analog of the clinically validated immunomodulator ​lenalidomide (CC-5013), featuring five strategic deuterium substitutions that improve metabolic stability while preserving its molecular glue mechanism.
DC67350 Cyclosporin A acetate-d4 Featured Cyclosporin A acetate-d4 is a deuterium-enriched analog of the cyclic undecapeptide immunosuppressant, featuring four strategic deuterium substitutions that improve metabolic stability while preserving its dual mechanism of action.
DC67353 HuR degrader 2 Featured HuR Degrader 2 (Compound 3) is a molecular glue that targets the RNA-binding protein HuR, degrading ~30% of HuR at 0.1 μM. It inhibits the proliferation of Colo-205 cancer cells with an IC50 ≤ 200 nM and exhibits high cereblon binding affinity, as evidenced by an HTRF ratio < 0.02.
DC67354 Lenalidomide hydrochloride Featured Lenalidomide hydrochloride (CC-5013 hydrochloride), a thalidomide-derived molecular glue, functions as an orally bioavailable immunomodulatory agent. By binding to the ubiquitin E3 ligase cereblon (CRBN), it recruits the CRBN-CRL4 complex to induce selective ubiquitination and degradation of lymphoid transcription factors IKZF1 and IKZF3. This mechanism underlies its potent activity against mature B-cell malignancies, including multiple myeloma, while also stimulating IL-2 secretion from T cells.
DC67355 Pomalidomide-d4 Featured Pomalidomide-d4 is a deuterium-labeled analog of pomalidomide, a third-generation immunomodulatory drug functioning as a molecular glue degrader. This compound selectively binds the cereblon E3 ubiquitin ligase complex, triggering targeted proteasomal degradation of Ikaros family transcription factors—a key mechanism underlying its therapeutic activity.
DC67356 IPS-06061 Featured IPS-06061 is an orally bioavailable molecular glue that mediates targeted degradation of KRAS G12D through formation of a CRBN-KRASG12D-IPS06061 ternary complex, demonstrating potent activity with a DC50 below 500 nM.
DC67357 KT-333 diammonium Featured KT-333 diammonium is a molecular glue degrader that selectively targets STAT3 for proteasomal degradation by bridging interactions between STAT3 and the VHL E3 ubiquitin ligase complex. Exhibiting high specificity for STAT3 degradation, this compound demonstrates potent antitumor efficacy. Its therapeutic potential is particularly relevant in hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL).
DC67358 BRD9 Degrader-4 Featured BRD9 Degrader-4 (BRD9c) is a highly potent bifunctional molecular glue compound that induces targeted degradation of BRD9, demonstrating exceptional activity with a DC50 value of 25 nM or lower. This degradative capability translates to significant anti-tumor efficacy, highlighting its potential as a therapeutic agent.
DC67359 FIZ1 degrader 1 Featured FIZ1 degrader 1 (compound 1) represents a novel IMiD-derived molecular glue compound engineered for targeted FIZ1 protein degradation.
DC67360 GSPT1 degrader-4 Featured GSPT1 degrader-4 (compound 3) functions as a potent molecular glue targeting GSPT1, demonstrating a degradation concentration (DC50) of 25.4 nM. The compound exhibits strong anti-proliferative activity in CAL51 cells with an IC50 value of 39 nM.
DC67361 IKZF-IN-1 Featured IKZF-IN-1 (Compound I) is a molecular glue degrader that selectively targets IKZF1/2/3/4 (Ikaros zinc finger family proteins) for proteasomal degradation. This immunomodulatory compound holds therapeutic potential for investigating cancer and viral infection treatment strategies.
DC67362 QXG-6442 Featured QXG-6442 is a potent molecular glue degrader targeting CK1α, demonstrating high degradation efficiency (DC50 = 5.7 nM, Dmax = 90%). This compound significantly suppresses proliferation in the MOLM-14 leukemia cell line, highlighting its therapeutic potential.
DC67363 Antitumor agent-100 hydrochloride Featured Antitumor agent-100 (compound A6) hydrochloride is an orally bioavailable molecular glue that selectively targets the PDE3A-SLFN12 complex (IC50 = 0.3 μM). By binding to the PDE3A catalytic pocket, it stabilizes SLFN12 interaction, subsequently inhibiting protein translation and triggering apoptotic cell death. This dual mechanism underlies its potent antitumor activity.
DC67364 dCK1α-2 Featured dCK1α-2 is an orally bioavailable molecular glue degrader targeting CK1α, a key regulator of p53 pathway signaling. This compound demonstrates robust in vivo anti-tumor activity in murine models while upregulating expression of p53-associated genes, highlighting its dual mechanism of action.
DC67365 3-Indoleacetic acid-d4 Featured 3-Indoleacetic acid-d4 (Indole-3-acetic acid-d4; 3-IAA-d4) is a deuterium-stabilized isotopologue of the endogenous auxin phytohormone 3-indoleacetic acid (HY-18569). As the predominant natural auxin, 3-IAA regulates fundamental plant growth processes, including cellular elongation and proliferation, when supplemented in plant tissue culture systems.
DC67366 KT-333 ammonium Featured KT-333 ammonium (Compound A) is a targeted molecular glue degrader that induces STAT3 protein degradation via the ubiquitin-proteasome pathway. The compound facilitates this process by simultaneously engaging both STAT3 and the VHL E3 ubiquitin ligase, demonstrating remarkable degradation selectivity. With potent antitumor efficacy, KT-333 ammonium shows particular promise for investigating therapeutic interventions in hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL).
DC67367 Lenalidomide-13C5,15N Featured Lenalidomide-13C5,15N is an isotopically labeled analog of lenalidomide (HY-A0003; CC-5013), a thalidomide-derived molecular glue compound. This orally bioavailable immunomodulator functions through selective cereblon (CRBN) E3 ubiquitin ligase engagement, mediating targeted ubiquitination and proteasomal degradation of lymphoid transcription factors IKZF1 and IKZF3 via the CRBN-CRL4 complex. The compound demonstrates dual therapeutic activity by both suppressing proliferation of mature B-cell malignancies (including multiple myeloma) and enhancing T-cell immunostimulation through IL-2 induction.
DC67368 rac-Lenalidomide-13C5 Featured rac-Lenalidomide-13C5 is a carbon-13 labeled racemic variant of lenalidomide, designed for tracer studies in pharmacokinetic and metabolic research.
DC67369 AR Degrader-2 Featured AR Degrader-2 (Compound 2) is a molecular glue compound that induces targeted degradation of the androgen receptor (AR), demonstrating potent activity with a DC50 ranging from 0.3 to 0.5 μM in VCaP prostate cancer cells.
DC67370 BRD9 Degrader-2 Featured BRD9 Degrader-2 (Compound B11) is a highly potent and efficient molecular degrader of BRD9, achieving sub-nanomolar degradation activity (DC50 ≤1.25 nM) with maximal degradation exceeding 75%. This compound represents a promising chemical tool for investigating BRD9-dependent oncogenic pathways in cancer research.
DC67371 ChREBPα/14-3-3 regulator-1 Featured ChREBPα/14-3-3 regulator-1 (Compound 43) is a selective molecular glue that stabilizes the ChREBP/14-3-3 protein complex with an EC50 of 3.8 μM. By enhancing this interaction, the compound demonstrates cytoprotective effects against glucolipotoxicity in pancreatic β cells while preserving cellular function. These properties position it as a promising investigational tool for type 2 diabetes research.
DC67372 3-Indoleacetic acid (standard) Featured 3-Indoleacetic acid (Standard) serves as an analytically validated reference material for the phytohormone indole-3-acetic acid (IAA). Designed for precision research applications, this auxin-class plant growth regulator modulates fundamental developmental processes including cellular expansion, tissue differentiation, and organ morphogenesis, driving vegetative growth in plant systems.
DC67373 BRD4 degrader-2 Featured BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue that orchestrates targeted BRD4 degradation through ternary complex formation with the E3 ligase RNF126. This compound selectively engages both BRD4 isoforms (long and short) for proteasomal elimination, demonstrating pan-isoform degradation capability in cellular systems.
DC67374 AR Degrader-1 Featured AR Degrader-1 (Compound ML 2-9) is a monovalent molecular glue that selectively targets the androgen receptor (AR) for degradation via recruitment of the DCAF16 E3 ubiquitin ligase. Demonstrating a favorable safety profile, this compound effectively degrades AR in LNCaP prostate cancer cells without inducing significant cytotoxicity.
DC67375 IKZF3 degrader 1 Featured IKZF3 degrader 1 (compound 19a) is a potent molecular glue that induces targeted IKZF3 degradation (EC50 = 12 nM) by facilitating its recruitment to the cereblon (CRBN) E3 ubiquitin ligase complex. This enforced protein-protein interaction triggers subsequent ubiquitination and proteasomal elimination of IKZF3.

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