| DC8925 |
Atipamezole
Featured
|
Atipamezole(MPV1248) is an alpha-adrenoceptor antagonist with high affinity and selectivity for the alpha 2-receptor. |
|
| DC9946 |
Lanabecestat(AZD3293,LY-3314814) |
AZD3293 is a potent and selective orally active, brain-permeable BACE1 inhibitor,currently in development as a potential treatment for early Alzheimer’s disease. |
|
| DC8400 |
AZD3839
Featured
|
AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1. |
|
| DC8338 |
Azeliragon（PF-04494700,TTP488）
Featured
|
Azeliragon is an oral, small-molecule inhibitor of RAGE. |
|
| DC9935 |
Basmisanil(RG1662)
Featured
|
Basmisanil is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors which is under development by Roche for the treatment of cognitive impairment associated with Down syndrome. |
|
| DC9826 |
BCTC
Featured
|
BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
|
| DC11105 |
Umibecestat
Featured
|
beta-secretase inhibitor. |
|
| DC11389 |
BI 409306
Featured
|
BI 409306 is an inhibitor of phosphodisterase 9A（PDE9A）. |
|
| DC10404 |
BIA 10-2474
Featured
|
BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions. |
|
| DC8882 |
Bitopertin
Featured
|
Bitopertin, also known as RG1678, is a potent and selective inhibitor of GlyT1 with an EC50 of 30nM. |
|
| DC3114 |
Avagacestat (BMS-708163)
Featured
|
BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively. |
|
| DC8883 |
BP897
Featured
|
BP897 is a partially selective D3 dopamine receptor agonist. |
|
| DC7097 |
Cebranopadol(GRT-6005)
Featured
|
branopadol(GRT-6005) is a novel first in class compounds with potent agonist activity on ORL-1 (opioid receptor like -1) and the well established mu opioid receptor. |
|
| DC11038 |
Bryostatin 1
Featured
|
Bryostatin 1 (NSC 339555) is a macrocyclic lactone derived from a marine invertebrate, fuctions as an activator of PKC with high binding affinity (Ki=1.35 nM). |
|
| DC9765 |
CERC-501(LY-2456302,Aticaprant)
Featured
|
CERC-501(LY-2456302) is a potent, selective antagonist of the kappa opioid receptor (KOR) (Ki = 0.81 nM vs. 24.0 nM and 155 nM for the μ-opioid receptor (MOR) and δ-opioid receptor (DOR), respectively. |
|
| DCAPI1569 |
Cilostazol |
Cilastazol is a 2-oxo-quinoline with vasodilator, antimitogenic, antithrombotic, and cardiotonic properties. This compound has been shown to cause inhibition of adenosine uptake, eventually resulting in changes to cAMP levels. Studies have shown Cilostazo |
|
| DC11673 |
CK-2127107
Featured
|
CK-2127107(CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM. |
|
| DC9067 |
Clozapine |
Clozapine(HF 1854) is a 5-HT2A/2C and dopamine receptor blocker with Ki values of 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively. |
|
| DC8095 |
Raxatrigine hydrochloride
Featured
|
CNV1014802(GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. |
|
| DC10506 |
CPHPC(Miridesap)
Featured
|
CPHPC(GSK2315698,Miridesap) is a divalent crosslinker of SAP that causes rapid depletion of circulating SAP via hepatic clearance. |
|
| DC7391 |
CVT-10216
Featured
|
CVT-10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). |
|
| DC9551 |
Difluprednate
Featured
|
Difluprednate(Durezol) is a corticosteroid, approved difluprednate for the treatment of post-operative ocular inflammation and pain.
|
|
| DC11103 |
Tavapadon
Featured
|
Tavapadon is a potent, orally-bioavailable, selective partial agonist of the dopamine D1 and D5 receptors. |
|
| DC8277 |
E-2012
Featured
|
E 2012 is a potent γ-secretase modulator. |
|
| DC11551 |
Elenbecestat
Featured
|
Elenbecestat (E2609) is a novel potent, oral BACE1 inhibitor for treatment of Alzheimer's disease.. |
|
| DC8323 |
Eletriptan HBr
Featured
|
Eletriptan HBr is an orally active, selective 5-HT1B/1D receptor agonist. |
|
| DC8268 |
Eliprodil
Featured
|
Eliprodil is a non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. |
|
| DC10869 |
Olodanrigan(EMA401)
Featured
|
EMA401(Olodanrigan) is a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. |
|
| DC11028 |
EMD-281014 hydrochloride |
EMD-281014 hydrochloride is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM, displays little to no affinity for 5-HT2C receptors (Ki=557 nM), human D2 receptors and IKr channels. |
|
| DC11027 |
EMD-281014 |
EMD-281014 is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM, displays little to no affinity for 5-HT2C receptors (Ki=557 nM), human D2 receptors and IKr channels. |
|
