| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11010 | H3B-5942 | H3B-5942 is an orally available, selective estrogen receptor covalent antagonist (SERCA), demonstrates potent ERαantagonist activity in vitro and in vivo. |
|
| DC21105 | H3B-8800 Featured | H3B8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WT or mutant SF3B1 (binding IC50 of 0.3-2 nM),demonstrates dose-dependent inhibition of both canonical splicing and aberrant splicing induced by mutant SF3B1 in in vitro assays of biochemical splicing, induces lethality in spliceosome-mutant cancer cells.. H3B-8800 potently and preferentially kills spliceosome-mutant epithelial and hematologic tumor cells. |
|
| DC12266 | H4 Receptor antagonist 1 | H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM. |
|
| DC20106 | H4R antagonist 1 | H4R antagonist 1 |
|
| DC1066 | HA14-1 Featured | HA14-1 is a nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of~9 μM. |
|
| DC9567 | Halcinonide | Halcinonide is a high potency corticosteroid used topically in the treatment of certain skin conditions. |
|
| DC9749 | Halofuginone | Halofuginone is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal. |
|
| DC10935 | HAMI3379 | HAMI3379 (HAMI-3379) is a potent and selective antagonist of cysteinyl leukotriene 2 (CysLT(2)) receptor, inhibits LTD4- and LTC4-induced intracellular calcium mobilization withIC50 of 3.8 nM and 4.4 nM respectively. |
|
| DC21106 | HAP-12 | HAP-12 is a small molecule HBV capsid assembly effector that inhibits HBV DNA replication with EC50 of 0.5 uM.. |
|
| DC23253 | HAR-171 | HAR-171 is a small molecule gp120-CD40 blocker that acts as a highly potent HIV entry inhibitor with IC50 of 0.43 uM against YTA48P virus with no significant cytotoxicity (CC50>120 uM).. |
|
| DC12224 | H-Arg-4MβNA | H-Arg-4MβNA is a substrate for cathepsin H, used for the detection of enzyme activity in gel electrophoresis. |
|
| DC23634 | HBT1 | HBT1 is a novel potent AMPA receptor potentiator with lower agonistic effect compared with LY451395 and OXP1.. |
|
| DC20917 | HBV Capsid inhibitor 3711 | HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation. |
|
| DC10354 | HBX 19818 Featured | HBX 19818 is a selective USP7 inhibitor with IC50 of 28.1 uM . |
|
| DC23783 | HBX 28258 | HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1. |
|
| DC12197 | HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide) | HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na+]i rise is slowed by HC-056456 (IC50~3 µM). |
|
| DC21108 | HC-070 | HC-070 is a potent, selective, orally active inhibitor of TRPC4 and TRPC5 channel with IC50 of 9.3 and 46 nM (calcium influx inhibition), respectively. |
|
| DC10932 | HDAC6 degrader 9c | HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand. |
|
| DC20401 | HDAC6-AR-IN-10 | HDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM, shows weak inhibition on HDAC1/2/3 (IC50>1 uM). |
|
| DC11594 | HDAC8-IN-20a | HDAC8-IN-20a is a potent, selective HDAC8 inhibitor with IC50 of 27 nM. |
|
| DC21113 | HEC72702 | HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM. |
|
| DC21114 | HEC-73543 | HEC-73543 is a novel potent, selective, orally bioavailable FLT3 inhibitor for the treatment of refractory acute myeloid leukemia (AML). |
|
| DC20402 | Hedgehog-IN-7d | Hedgehog-IN-7d is a potent, cell-permeable Hedgehog (Hh) pathway inhibitor that inhibits Gli transcription activity with an IC50 value of 70 nM.. |
|
| DC21414 | Helenalin | Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway. |
|
| DC21109 | Hemicholinium-3 | Hemicholinium-3 (HC-3) is a competitive, small molecule inhibitor of choline kinase (ChoK) with ex vivo IC50 of 500 uM, also bolcks the sodium and chloride-dependent transport system and affects choline acetyltransferase. |
|
| DC24152 | Hemin | Hemin, a physiological erythroid maturation stimulator, is able to induce the expression of critical autophagic genes (Map1a1b (LC3), Beclin-1 gen, Atg5) in an erythroleukemia cell type. |
|
| DC21115 | TD-1 Featured | Hemoglobin modulator TD-1 (TD-1) is a novel allosteric effector of hemoglobin that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling. |
|
| DC12294 | Heparin lithium salt Featured | Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII). |
|
| DC10422 | Heptamethine cyanine dye-1 | Heptamethine cyanine dye-1 is a near-infrared cyanine dye for fluorescence imaging in biological systems. |
|
| DC20403 | HER2-IN-2 | HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases. |
|
