| DC10354 |
HBX 19818
Featured
|
HBX 19818 is a selective USP7 inhibitor with IC50 of 28.1 uM . |
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| DC23783 |
HBX 28258 |
HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1. |
|
| DC12197 |
HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide) |
HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na+]i rise is slowed by HC-056456 (IC50~3 µM). |
|
| DC21108 |
HC-070 |
HC-070 is a potent, selective, orally active inhibitor of TRPC4 and TRPC5 channel with IC50 of 9.3 and 46 nM (calcium influx inhibition), respectively. |
|
| DC10932 |
HDAC6 degrader 9c |
HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand. |
|
| DC20401 |
HDAC6-AR-IN-10 |
HDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM, shows weak inhibition on HDAC1/2/3 (IC50>1 uM). |
|
| DC11594 |
HDAC8-IN-20a |
HDAC8-IN-20a is a potent, selective HDAC8 inhibitor with IC50 of 27 nM. |
|
| DC21113 |
HEC72702 |
HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM. |
|
| DC21114 |
HEC-73543 |
HEC-73543 is a novel potent, selective, orally bioavailable FLT3 inhibitor for the treatment of refractory acute myeloid leukemia (AML). |
|
| DC20402 |
Hedgehog-IN-7d |
Hedgehog-IN-7d is a potent, cell-permeable Hedgehog (Hh) pathway inhibitor that inhibits Gli transcription activity with an IC50 value of 70 nM.. |
|
| DC21414 |
Helenalin |
Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway. |
|
| DC21109 |
Hemicholinium-3 |
Hemicholinium-3 (HC-3) is a competitive, small molecule inhibitor of choline kinase (ChoK) with ex vivo IC50 of 500 uM, also bolcks the sodium and chloride-dependent transport system and affects choline acetyltransferase. |
|
| DC24152 |
Hemin |
Hemin, a physiological erythroid maturation stimulator, is able to induce the expression of critical autophagic genes (Map1a1b (LC3), Beclin-1 gen, Atg5) in an erythroleukemia cell type. |
|
| DC21115 |
TD-1
Featured
|
Hemoglobin modulator TD-1 (TD-1) is a novel allosteric effector of hemoglobin that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling. |
|
| DC12294 |
Heparin lithium salt
Featured
|
Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII). |
|
| DC10422 |
Heptamethine cyanine dye-1 |
Heptamethine cyanine dye-1 is a near-infrared cyanine dye for fluorescence imaging in biological systems. |
|
| DC20403 |
HER2-IN-2 |
HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases. |
|
| DC20404 |
HER2-IN-3 |
HER2-IN-3 is a type I HER2 inhibitor that has a similar profile to HER2-IN-2. |
|
| DC23730 |
Herboxidiene |
Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome. |
|
| DC10967 |
HET0016 |
HET0016 (HET-0016) is a potent, selective inhibitor of CYP4A, potently inhibits the formation of 20-HETE with IC50 of 8.9 nM in human renal microsomes. |
|
| DC12717 |
Hetrombopag |
Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist. |
|
| DC12227 |
Hexacosanoic acid |
Hexacosanoic acid is a long-chain fatty acid related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis. |
|
| DC12306 |
Hexamethylquercetagetin |
Hexamethylquercetagetin is a polymethoxylated flavone in peels of citrus cultivars. |
|
| DC8680 |
Hexaminolevulinate hydrochloride |
Hexaminolevulinate hydrochloride is a fluorescent agent, has approved for cystoscopic detection of papillary bladder cancer. |
|
| DC12707 |
Hexokinase 2 modulator Comp-1 |
Hexokinase 2 modulator Comp-1 is a potent, selective small molecule modulator of Hexokinase 2 (HK2) interaction with the mitochondria, selectively dissociates HK2 from VDAC1 in vitro with IC50 of 92 nM. |
|
| DC21904 |
HG-12-6 |
HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM). |
|
| DC23141 |
HG6-64-1 |
HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively. |
|
| DC20405 |
HG-7-27-01 |
HG-7-27-01 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 224 nM, displays intermediate selectivity profiles (selectivity score=0.16) against 442 kinases.. |
|
| DC21379 |
HG-7-92-01(NG25)
Featured
|
HG-7-92-01 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 292 nM, displays intermediate selectivity profiles (selectivity score=0.18) against 353 kinases.. |
|
| DC26060 |
gly-arg p-nitroanilide dihydrochloride
Featured
|
H-Gly-Arg-pNA is a colorimetric substrate for thrombin. |
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