A potent CYP26A1 inhibitor with IC50 of 10 nM, potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with IC50 of 8.7 nM.

Beaucage reagent is a DNA cleavage reagent.

A potent dopamine D2 receptor antagonist with Ki of 28 nM.

A potent dopamine D2 receptor antagonist with Ki of 28 nM.

A potent dopamine stabilizer with Ki of 447 and 1305 nM for D2 and D3 receptors respectively.

A potent dual H3/H2 receptor antagonist with Ki of 0.07 and 7.8 uM, respectively.

A potent dual inhibitor of EGFR and ErbB2.

A potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint.

A potent GIRK2 inhibitor that inhibits GIRK2-mediated flux with an IC50 of 0.35 uM.

A potent glucagon receptor (GCGR) negative allosteric modulator..

A potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM.

A potent gucokinase (GK) activator with EC50 of 0.29 uM.

Daclatasvir is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) and is used in combination with other oral antiviral agents to treat chronic hepatitis C. Elevations in serum enzyme levels during daclatasvir therapy are uncommon, and it has yet to be convincingly implicated in cases of clinically apparent liver injury with jaundice. Nevertheless, and for unknown reasons, successful all-oral regimens of antiviral therapy in patients with chronic hepatitis C and cirrhosis is occasionally complicated by hepatic decompensation and may cause reactivation of hepatitis B in susceptible patients coinfected with the hepatitis B virus (HBV).

A potent HCV NS5B RNA polymerase inhibitor.

A potent HDAC inhibitor with IC50 of 172 nM.

A potent HDAC inhibitor with IC50 of 27 nM (HeLa cell extracts).

A potent heat shock protein coinducer.

A potent hERG channel activator that concentration-dependently increases the hERG current (2.1 and 3.4-fold at 3 and 10 uM, respectively) and markedly slows hERG channel deactivation and inactivation.

A potent HIF-2α inhibitor with IC50 of <500 nM in HIF-2α scintillation proximity assay. .

A potent histamine 1 receptor antagonist..

A potent HIV integrase strand transfer inhibitor (InSTIs) with IC50 of 8 nM in HIV replication assay.

A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction.