| DC20374 |
EphB3-IN-1 |
EphB3-IN-1 is the first potent, selective inhibitor of EphB3 that exhibits inhibiting EphB3 autophosphorylation in cells with IC50 of 3 nM. |
|
| DC11433 |
Vatiquinone |
EPI-743 (Vatiquinone,EPI-589) is an orally bioavailable para-benzoquinone for treatment of inherited mitochondrial diseases, an analogue of the antioxidant ubidecarenone. |
|
| DC8693 |
Epiandrosterone
Featured
|
Epiandrosterone is a steroid hormone with weak androgenic activity. Epiandrosterone is naturally produced by the enzyme 5α-reductase from the adrenal hormone DHEA. |
|
| DC9363 |
Epibrassinolide |
Epibrassinolide (EBR; B1105; 24-Epibrassinolide) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family; was shown as a potential apoptotic inducer in various cancer cells without affecting the non-tumor c |
|
| DC23071 |
Epigoitrin
Featured
|
Epigoitrin and fructopyrano-(1→4)-glucopyranose(FG) from the traditional Chinese medicine Isatidis radix, exhibit in vitro cooperation, they have in vitro anti-virus activity. |
|
| DCAPI1014 |
Eplerenone
Featured
|
Eplerenone, also known as Inspra and CGP-30083, is a selective aldosterone receptor antagonist used to treat hypertension and congestive heart failure. Eplerenone provides marked protection against vascular injury in the kidney and heart.
|
|
| DC23786 |
Epolactaene |
Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells. |
|
| DC7120 |
Epothilone A |
Epothilone A is a Taxol-like microtubule-stabilizing agent that induces tubulin polymerization, leading to cell cycle arrest at the G2-M transition, cytotoxicity, and apoptosis. |
|
| DC7012 |
Epothilone D |
Epothilone D(Desoxyepothilone B; KOS 862) is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. |
|
| DC8030 |
Epoxomicin
Featured
|
Epoxomicin is a selective and irreversible inhibitor of 20S proteasome with an IC50 value of 4 nM. |
|
| DC12311 |
Eprobemide (LIS 630)
Featured
|
Eprobemide is a non-competitive reversible inhibitor of monoamine oxidase A. |
|
| DC9171 |
Eprosartan mesylate |
Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively. |
|
| DC5182 |
EPZ004777
Featured
|
EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM. |
|
| DC7121 |
EPZ005687
Featured
|
EPZ-005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases. |
|
| DC26000 |
EPZ019997
Featured
|
EPZ019997 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). |
|
| DC12529 |
EPZ020411 dihydrochloride |
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
|
| DC23134 |
EPZ020411 hydrochloride |
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
|
| DC20996 |
EPZ 025654 |
EPZ025654 (GSK 35336023) is a potent, selective arginine methyltransferase CARM1 inhibitor with IC50 of 3 nM. |
|
| DC22657 |
EPZ-030456 |
EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM. |
|
| DC7122 |
Tazemetostat(EPZ-6438)
Featured
|
EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity with Ki value of 2.5±0.5 nM. |
|
| DC8595 |
Equisetin |
Equisetin is an N-methylserine-derived acyl tetramic acid produced by a number of Fusarium species with antibiotic and cytotoxic activity. |
|
| DC20997 |
ER000444793
Featured
|
ER-000444793 is a potent, cyclophilin D-independent inhibitor of mitochondrial permeability transition pore (mPTP) with with IC50 of 2.8 uM. |
|
| DC22468 |
ER-27319 maleate |
ER-27319 maleate is a potent, selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells by selective inhibition of FcɛRI-mediated activation of Syk. |
|
| DC22090 |
ER-464195-01 |
ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5. |
|
| DC22433 |
ER-819762 |
ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay. |
|
| DC7410 |
Erastin
Featured
|
Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. |
|
| DC11238 |
ERD03 |
ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish. |
|
| DCAPI1365 |
Erdosteine |
Erdosteine |
|
| DC21416 |
ERGi-USU |
ERGi-USU (NSC139021) is a small molecule that selectively inhibits ERG-positive cancer cell growth (VCaP cell IC50=0.169 uM), directly binds the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature. |
|
| DC23055 |
Erianin
Featured
|
Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis. |
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