DC8721 |
Sirtinol
Featured
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Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. |
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DC9898 |
SIS3
Featured
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SIS3 is a potent and selective inhibitor of Smad3. a potent regulator of the human Nox4 promoter. |
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DCAPI1086 |
Sitafloxacin hydrate
Featured
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Sitafloxacin Hydrate is a new-generation, broad-spectrum oral fluoroquinolone antibiotic. |
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DC5112 |
Sitagliptin (Metformin,MK-0431) |
Sitagliptin phosphate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts. |
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DC10901 |
SJ000291942
Featured
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SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules. |
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DC20591 |
SJ-733 |
SJ-733 (SJ000557733. |
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DC21654 |
SJ830599 |
SJ830599 is a modest selective BRD2-BD2 inhibitor with IC50 of 0.61 uM, 3.3-fold selectivity over BRD2-BD1. |
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DC26019 |
SJA710-6
Featured
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SJA710-6 (a Hepatic Differentiation Inducer) is a novel, potent and cell-permeable small molecule imidazopyridinamine compound that is able to induce the differentiation of rat MSCs (rMSCs) toward hepatocyte-like cells (~47% at 5 µM). |
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DC21655 |
SJB7
Featured
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SJB7 is a close analog of SPA70 and hPXR agonist, interacts with the ligand-binding domain (LBD) of hPXR.. |
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DC22450 |
SK 216 |
SK 216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM. |
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DC23427 |
SK609(SK-609;SK 609;ES609) |
SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation. |
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DC20104 |
Skatole
Featured
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Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. |
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DC7765 |
Skepinone-L
Featured
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Skepinone-L is a selective p38α-MAPK inhibitor with IC50 of 5 nM. |
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DC23451 |
SKF-38393 hydrobromide |
SKF-38393 is a potent, selective D1/D5 receptor partial agonist with Ki of 1 and 0.5 nM, respectively. |
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DC21659 |
SKI-178
Featured
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SKI-178 is a potent, specific, non-lipid SphK1 inhibitor with Ki of 1.33 uM, displays no significant activity for SphK2 (IC50>25 uM). |
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DC21660 |
SKLB188 |
SKLB188 is a novel multikinase inhibitor and potently inhibits EGFR with IC50 of 5 nM. |
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DC12619 |
SKLB-C05 |
SKLB-C05 is a novel selective, orally active TOPK inhibitor with IC50 of 0.5 nM, shows excellent cytotoxicity and anti-migration and invasion activity on TOPK high-expressing CRC cells and induces cell apoptosis. |
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DC8500 |
SKQ1(Visomitin)
Featured
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SKQ1 prevents amyloid-beta-induced impairment of long-term potentiation in rat hippocampal slices. |
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DC8740 |
SL327
Featured
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SL-327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively). |
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DC20552 |
SLC25A20-IN-21 |
SLC25A20-IN-21 is a SLC25A20 ligand that increases long-chain (>C14) acylcarnitine content and reduces maximal exogenous fatty acid oxidation in HSC-5 cells. |
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DC12314 |
SLLK, Control Peptide for TSP1 Inhibitor(TFA)
Featured
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SLLK, Control Peptide for TSP1 Inhibitor (TFA) is a control peptide for LSKL, which is a Thrombospondin (TSP-1) inhibitor. |
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DC22005 |
SLLN-15 |
SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models, promotes AURKA degradation and . |
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DC23294 |
SM-1295 |
SM-1295 is a potent, selective cIAP1 and cIAP2 inhibitor with Ki of <10 nM, displays >900-fold for cIAP1 over XIAP. |
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DC23295 |
SM13 |
SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo. |
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DC8490 |
SM-164
Featured
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SM-164 is a bivalent mimetic of Smac with Ki values of 0.31 nM, 1.1 nM and 0.56 nM for cIAP-1, cIAP-2 and XIAP, respectively |
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DC22723 |
SM-324405 |
SM-324405 is a potent, selective TLR7 agonist with EC50 of 50 nM, induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, inhibits IL-5 production in human PBMCs in vitro.. |
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DC22537 |
SMAP
Featured
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SMAP (DT-061, DT061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth. |
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DC21662 |
SMAP-2 |
SMAP-2 (DT-1154) is an orally bioavailable small molecule activator of PP2A, binds to PP2A Aα scaffold subunit and inhibits KRAS-driven tumor growth both in vitro and in vivo. |
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DC20762 |
SMARt-420 |
SMARt-420 (BDM 41420) is a small molecule that can fully reverses ethionamide-acquired resistance and clears ethionamide-resistant M. tuberculosis infection in mice, also increases the basal sensitivity of bacteria to ethionamide.. |
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DC7895 |
SMER3(SMER 3) |
SMER3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. |
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