DC22237 |
ST-148 |
ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV Capsid protein. |
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DC21698 |
ST-162 |
ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively. |
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DC21699 |
ST-168 |
ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. |
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DC12110 |
ST3932 |
ST3932 is a metabolite of ST1535, acts as an antagonist of adenosine A2A receptor, with Kis of 8 nM and 33 nM for A2A and A1 receptors, respectively. |
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DC25041 |
STA 2842 |
STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90. |
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DC12127 |
Stachyose tetrahydrate |
Stachyose is a prebiotic, a non-reducing tetrasaccharide in the rafnose family of oligosaccharides with few side efects. |
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DC21701 |
Stafib-2
Featured
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Stafib-2 (Stafib 2) is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 9 nM, >20-fold selectivity over STAT5a.. |
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DC20860 |
STAT5b inhibitor 7 |
STAT5b inhibitor 7 (Capstafin prodrug) is the pivaloyloxymethyl ester prodrug of Capstafin, which is a potent, selective STAT5b inhibitor with Ki of 0.34 uM. |
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DC7981 |
STATIL
Featured
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Statil is shown to be a potent aldose reductase inhibitor. |
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DC7613 |
STATTIC
Featured
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Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. |
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DC8979 |
Stavudine
Featured
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Stavudine is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. |
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DC23481 |
STD-101-D1
Featured
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STD-101-D1 is a novel brain permeable, G protein-biased beta-1 adrenergic receptor (ADRB1) partial agonist with EC50 of 16.9 nM. |
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DC12503 |
STD1T
Featured
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STD1T (USP2a inhibitor STD1T) is a hit-to-lead, small-molecule inhibitor of USP2a with IC50 of 3.3 uM in Ub-AMC assays, displays no activity against USP7 at 10 uM. |
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DC12204 |
Stearic acid |
Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils. |
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DC12209 |
Stearoylcarnitine |
Stearoylcarnitine is a fatty ester lipid molecule. |
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DC5142 |
StemRegenin 1(SR-1)
Featured
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StemRegenin 1 antagonizes hematopoietic stem cell differentiation. |
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DC23093 |
双甜
Featured
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Steviolbioside is a natural sweetener, it presents notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3 |
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DC22470 |
Stibogluconate sodium |
Stibogluconate sodium (Sodium stibogluconate) is a multiple antimony compound that has leishmanicidal and potential antineoplastic activities, inhibits protein tyrosine phosphorylase SHP-1 (99% inhibtion at 10 ug/mL), SHP-2 and PTP1B, shows anticancer act |
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DC23319 |
STIMA 1 |
STIMA 1 is a small molecule mutant p53 reactivator that can stimulate mutant p53 DNA binding in vitro, induces expression of p53 target proteins and triggers apoptosis in mutant p53-expressing human tumor cells.. |
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DC12505 |
STING agonist-4
Featured
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STING agonist 4 is an amidobenzimidazole (ABZI)-based compound that functions as a STING agonist with Kd of 1.6 nM (binding of endogenous full-length STING, THP-1 cell lysates); caused dose-dependent phosphorylation of IRF3 and STING that was inhibited by the TBK1 inhibitor BX795, induced dose-dependent secretion of IFN-β with EC50 of 3.1 uM in PBMCs (18-fold more potent than cGAMP); promotes production of IFN-γ-induced protein 10 (IP-10), IL-6 and TNFα by a mechanism that is dependent on STING-mediated activation of TBK1; unlike cGAMP and DMXAA, compound 2 efficiently activates STING function while maintaining an open STING confirmation. |
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DC10201 |
STK16-IN-1
Featured
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STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM. |
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DC9844 |
STK321130(FLT3-IN-2)
Featured
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STK321130(FLT3-IN-2)is potent FLT3 inhibitor |
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DC11264 |
STO-609 (acetate)
Featured
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STO-609 is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ (Ki = 80 and 15 ng/ml, respectively). |
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DCAPI1552 |
streptomycin
Featured
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Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes . |
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DCAPI1170 |
Streptomycin sulfate |
Streptomycin sulfate |
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DC20846 |
Streptonigrin |
Streptonigrin (Bruneomycin, NSC 45383) is a potent, selective, and irreversible PAD4 inactivator with IC50 of 1.87 uM, also binds directly to RAD54 with Kd of 9.1 uM, inhibits ATPase and DNA branch migration activity of RAD54. |
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DC23342 |
S-Trityl-L-cysteine |
S-Trityl-L-cysteine (NSC 83265) is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, inhibits basal ATPase activity (IC50=1 mM) and microtubule-activated ATPase activity of Eg5 (IC50=140 nM). |
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DC21709 |
SU 16f
Featured
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SU 16f is a potent and selective PDGFRβ inhibitor with IC50 of 10 nM, displays >14-fold, >229-fold and >10,000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. |
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DC10602 |
SU 4313
Featured
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SU 4313 is a bioactive chemical. |
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DC10601 |
SU 4942
Featured
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SU 4942 is a bioactive chemical. |
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