Cat. No. | Product name | CAS No. |
DC23358 |
CD 161
A potent, selective, orally bioavailable BET bromodomain inhibitor with IC50 of 7.2 and 28.2 nM for BRD4 BD2 and BRD4 BD1, respectively. |
1627716-22-6 |
DC21177 |
JNJ 39758979
A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM, >80-fold selectivity over other histamine receptors. |
1046447-90-8 |
DC24048 |
NVP-BKM120 hydrochloride
Featured
A potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively. |
1312445-63-8 |
DC22882 |
KRH-3955
A potent, selective, orally bioavailable inhibitor of CXCR4 that efficiently inhibits SDF-1α binding to CXCR4 with IC50 of 0.61 nM. |
1097732-62-1 |
DC24065 |
EPZ-011989 trifluoroacetate
A potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM. |
1598383-41-5 |
DC23552 |
AS-2444697 HCl
Featured
A potent, selective, orally bioavailable IRAK-4 inhibitor that potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1. |
1287665-60-4 |
DC22941 |
AZD-9056
A potent, selective, orally bioavailable P2X7 receptor antagonist. |
345304-65-6 |
DC21607 |
SB-649868
Featured
SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively). |
380899-24-1 |
DC21598 |
RWJ-56110
A potent, selective, peptide-mimetic PAR-1 antagonist with binding IC50 of 0.44 uM, with no effect on PAR-2, PAR-3, or PAR-4. |
252889-88-6 |
DC20691 |
ASP 3652
A potent, selective, peripherally active and orally available FAAH inhibitor for treatment of chronic prostatitis/chronic pelvic pain syndrome.. |
|
DC23043 |
Tpl2-IN-2p
A potent, selective, reversible and ATP-competitive inhibitor of Tpl2 kinase with IC50 of 50 nM. |
871307-18-5 |
DC23933 |
MK-0893
A potent, selective, reversible and competitive antagonist of glucagon receptor with high binding affinity (IC(=50=6.6 nM) and functional cAMP activity (IC50=15.7 nM). |
870823-12-4 |
DC20412 |
II-B08
A potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs. |
1143579-78-5 |
DC11875 |
GlpG inhibitor 11
A potent, selective, reversible rhomboid proteases inhibitor with Ki of 45 nM for GlpG . |
|
DC22892 |
KNT-127
A potent, selectove δ-opioid receptor agonist with Ki of 0.16 nM, dispalys 133.5-fold and 960.5-fold selectivity over μOR and κOR respectively. |
1256921-89-7 |
DC22563 |
TN1
A potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM. |
289479-94-3 |
DC20606 |
8-Thioquinoline
A potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 2.5 uM.. |
491-33-8 |
DC21321 |
ML349
Featured
A potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM, >20-fold selectivity over APT-1 and serine hydrolase enzyme family. |
890819-86-0 |
DC22529 |
FPTQ
A potent, specific and allosteric mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1, respectively.. |
864863-72-9 |
DC25075 |
Sivelestat sodium
A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM. |
150374-95-1 |
DC23074 |
Sivelestat
A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM. |
127373-66-4 |
DC23494 |
GRI 977143
Featured
A potent, specific and nonlipid agonist of LPA2 receptor with EC50 of 3.3 uM, does not activate any of the other LPA GPCRs (>10 uM). |
325850-81-5 |