DC23745 |
BAY-2402234
Featured
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BAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM (human full-length DHODH). |
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DC10291 |
Bay 41-4109 less active enantiomer |
Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. |
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DC20747 |
BAY 41-8543 |
BAY 41-8543 is an NO-independent sGC (soluble guanylyl cyclase) stimulator, inhibits collagen-mediated aggregation in washed human platelets (IC50=90 nM). |
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DC7323 |
Pritelivir(BAY-57-1293)
Featured
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BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex. |
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DC4113 |
Cinaciguat (BAY 58-2667)
Featured
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BAY 58-2667 is a nitric oxide (NO)- and heme-independent soluble guanylyl cyclase activator. Displays potent cardiovascular effects. |
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DC20748 |
BAY 60-2770 |
BAY 60-2770 is an NO-independent activator of sGC (soluble guanylyl cyclase) with EC50 of 5.4 nM. |
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DC23438 |
BAY 60-6583 |
BAY 60-6583 (BAY606583) is a potent, selective adenosine A2B receptor agonist with EC50 of 2.83 nM (murine A2BR). |
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DC26066 |
BAY 61-3606 hydrochloride
Featured
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BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase with Ki of 7.5 nM, displays no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
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DC9591 |
BAY 80-6946(Copanlisib)
Featured
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BAY 80-6946(Copanlisib) is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM.
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DC7996 |
BAY 87-2243
Featured
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BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation. |
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DC23559 |
Bay K-8644
Featured
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Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM, has positive inotropic, vasoconstrictive and behavioral effects in vivo. |
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DC22013 |
BAY-1316957
Featured
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BAY-1316957 (BAY 1316957) is a highly potent, selective, orally available human prostaglandin E2 receptor subtype 4 (hEP4-R) antagonist with IC50 of 15.3 nM. |
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DC20751 |
BAY-1816032
Featured
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BAY-1816032 (BAY1816032) is a highly potent, selective, orally active BUB1 mitotic checkpoint serine/threonine kinase with IC50 of 7 nM, displays excellent selectivity on a panel of 395 kinases. |
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DC26020 |
BAY2335218(BAY-218)
Featured
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BAY2335218(BAY-218) is the first-in-class AhR antagonist for overcoming tumor-mediated immunosuppression. |
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DC23816 |
BAY-293 racemate |
BAY-293 racemate (BAY293 racemate) is a potent SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 50 nM, the R-enantiomer (BAY-293) is the active form with IC50 of 21 nM, while the BAY-293 is less active (IC50=2,340 nM).. |
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DC11006 |
BAY-320 |
BAY-320 (BAY320) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 680 nM. |
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DC22015 |
BAY-386 |
BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM). |
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DC11007 |
BAY-524 |
BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM. |
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DC26010 |
BAY-545
Featured
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BAY-545 is a novel, potent and selective antagonist of A2B adenosine receptor with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66, 400, 280 nM for human, mouse, rat A2Badenosine receptor in cells, respectively. |
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DC12653 |
BAY-598
Featured
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BAY-598 is a selective inhibitor of SMYD2. |
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DC12088 |
BAY-678 racemate |
BAY-678 racemate is a chemical probe candidate for Human Neutrophil Elastase (HNE). |
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DC20749 |
BAY-707 |
BAY-707 is a highly potent, selective and substrate-competitive inhibitor of MTH1 (NUDT1) with IC50 of 2.3 nM. |
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DC22016 |
BAY-7598 |
BAY-7598 (BAY7598) is a potent, selective MMP12 inhibitor.. |
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DC22017 |
BAY-826 |
BAY-826 (BAY826) is a novel selective, highly potent, orally available TIE-2 inhibitor (dissociation constant=1.6 nM). |
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DC10057 |
Bayer-18
Featured
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Bayer-18 is a selective TYK2 inhibitor, with an IC50 of 18.7nM on TYK2 as measured by TYK2 HTRF assays. |
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DC12280 |
BB-Cl-Amidine |
BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor. |
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DC20754 |
BC-1215
Featured
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BC-1215 (BC1215) is a highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1β IC50 of 0.9 ug/mL. |
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DC20755 |
BC-1485 |
BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination. |
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DC21401 |
BC-21 |
BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM. |
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DC20757 |
BC-23 |
BC-23 (NSC 45382) is a novel inhibitor of β-catenin/Tcf4 interaction with IC50 of 1.7 uM. |
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