Home > Inhibitors & Agonists > Others
Cat. No. Product name CAS No.
DC9542 MPTP (hydrochloride) Featured

MPTP HCl induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats

23007-85-4
DC23877 MRK-560

MRK-560 is a potent, brain-penetrant and orally bioavailable γ-secretase inhibitor that inhibits proteolytic cleavage of APP over the Notch pathway.

677772-84-8
DC23655 MRK-623

MRK-623 is a potent, α2/α3 subunit functionally selectiviie GABAA receptor agonist..

461449-78-5
DC23616 MRK-696

MRK-696 is a non-selective benzodiazepine receptor partial agonist..

233275-67-7
DC21923 MRK-A

MRK-A is a potent, highly selective, brain penetrant inhibitor of mutant IDH1 with IC50 of 5 nM, displays a 10,000-fold mutant to wildtype selectivity ratio.

1934301-68-4
DC21343 MRL-1237

MRL-1237 is a potent and selective inhibitor of the replication of Enteroviruses with EC50 of 1-10 uM, targets the nonstructural 2C protein.

276704-21-3
DC23711 MRL20

MRL20 is a novel synthetic PPARγ ligand and orthosteric agonist with canonical LBP binding affinity of 2 nM.

393794-32-6
DC20220 MRS-1845 Featured

MRS 1845 is a potent calcium channel protein inhibitor and inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM).

544478-19-5
DC23483 MRS 2179

MRS 2179 is a potent, selective, competitive P2Y1 receptor antagonist with Kb of 100 nM.

101204-49-3
DC23471 MRS 2179 tetrasodium

MRS 2179 is a potent, selective, competitive P2Y1 receptor antagonist with Kb of 100 nM.

1454889-37-2
DC23733 MRS 2481

MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.

859724-30-4
DC23740 MRS 2485

MRS 2485 is a potent, irreversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity..

859724-34-8
DC12260 MRS1177

MRS1177 is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist, with a Ki of 0.3 nM.

183721-13-3
DC12251 MRS-1706 Featured

MRS-1706 is a potent and selective adenosine A2B receptor antagonist with Ki of 1.39 nM.

264622-53-9
DC12803 MRS1754 Featured

MRS1754 is a selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).

264622-58-4
DC22164 MRS4458

MRS4458 is a potent, highly specific amtagonist of P2Y14 receptor with IC50 of 169 nM, does not display extensive off-target interactions with biogenic amine receptors..

DC22165 MRS4478

MRS4478 is a potent, highly specific amtagonist of P2Y14 receptor with IC50 of 269 nM, does not display extensive off-target interactions with biogenic amine receptors..

DC21344 MRT 199665

MRT 199665 is a potent salt-inducible kinases (SIKs) inhibitor with IC50 of 110, 12, 43 nM for SIK1,2,3 respectively.

1456858-57-3
DC23898 MRT-83 hydrochloride

MRT-83 hydrochloride is a potent Smoothened antagonist that blocks Hedgehog (Hh) signaling in various assays with IC50 of 10 nM.

1359944-60-7
DC12651 MRTX1257 Featured

MRTX1257 (MRTX-1257, MRTX 1257) is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 0.9 nM.

2206736-04-9
DC21346 MS012

MS012 is a potent and selective inhibitor of G9a-Like Protein (GLP) lysine methyltransferase with IC50 of 7 nM, shows >30-fold selectivity for GLP over G9a and other methyltransferases..

2089617-83-2
DC21347 MS0124 Featured

MS-0124 is a potent and selective inhibitor of G9a-like Protein (GLP) lysine methyltransferase with IC50 of 13 nM, shows >30-fold selectivity for GLP over G9a and other methyltransferases..

1197196-63-6
DC21348 MS2734 Featured

MS2734 is a bisubstrate Nicotinamide N-methyltransferase (NNMT) with IC50 of 14 uM, Kd of 2.7 uM..

DC8574 MS37452 Featured

MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).

423748-02-1
DC21349 MS-377

MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities.

206862-30-8
DC22871 MS-402 Featured

MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice.

1672684-68-2
DC21350 MS4077

MS4077 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=3 nM).

2230077-10-6
DC21351 MS4078 Featured

MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM).

2229036-62-6
DC7620 MS436 Featured

MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM.

1395084-25-9
DC23316 MS7972

MS7972 is a small molecules that blocks p53 and CREB binding protein (CBP) association.

352553-42-5
DC20466 MsbA inhibitor 1 Featured

MsbA inhibitor 1 is a novel small molecule lipopolysaccharide biogenesis inhibitor, inhibits MsbA, an ATP-dependent flippase that translocates LPS across the inner membrane; causes mislocalization of LPS to the cell interior, inhibits Δ5 strain with MIC o

52535-76-9
DC21352 MSC 1094308

MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively.

2219320-08-6
DC22166 MSC2504877 Featured

MSC2504877 (MSC-2504877) a novel small molecule selective tankyrase inhibitor with IC50 of 0.7/0.8 nM against TNKS1/2, shows 771-fold selectivity for TNKS1 over PARP1 (IC50=0.54 uM).

1460286-21-8
DC10894 MSDC-0602 Featured

MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes.

1133819-87-0
DC21353 MSN-125

MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM.

1592908-16-1
DC22167 MT-802 Featured

MT-802 (MT802) is a potent BTK PROTAC that induces degradation of both wild-type and C481S mutant BTK (DC50=9.1 nM).

2231744-29-7
DC20061 MtbHU-IN-1

MtbHU-IN-1 is an inhibitor of Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU), with a Kd of 98 nM for binding to WT MtbHU.

59736-84-4
DC22139 MTI-31 Featured

MTI31 (LXI-15029, mTOR inhibitor-31) is a novel potent, selective mTORC1/mTORC2 inhibitor with Kd of 0.2 nM (mTOR), displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G.

1567915-38-1
DC20230 mTOR inhibitor-1 Featured

mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy.

468747-17-3
DC20468 Mtphagy Dye

Mtphagy Dye is a small-molecule fluorescent probe for visualizing mitophagy.

2137473-96-0
DC8240 3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium Featured

MTS is water-soluble and used in the MTS assay.

138169-43-4
DC22168 MU1210

MU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM (cellular BRET for CLK1).

DC22169 MU1300

MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly.

DC7205 Mubritinib (TAK 165) Featured

Mubritinib is a potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase.

366017-09-6
DC12212 Mulberrin (Kuwanon C)

Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM.

62949-79-5
DC23266 MUT-A

MUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.

1591906-37-4
DC21924 mutant IDH1 inhibitor VVS

mutant IDH1 inhibitor VVS is a potent, selective mutant IDH1 inhibitor with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line..

1648909-73-2
DC20258 MW150 (MW01-18-150SRM)

MW150 (MW01-18-150SRM) is a selective, brain penetrant p38αMAPK, which is efficacious in diverse animal models of neurologic disorders.

DC21355 MW181

MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.

1454658-87-7
DC21356 MW181 dihydrochloride

MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.

1628503-08-1
DC21357 MW181 hydrochloride

MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.

1454658-90-2
DC26051 MX1013 Featured

MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1

582316-00-5
DC22170 MX106

MX106 is a novel potent survivin inhibitor, effectively suppresses MDA-MB-231 cells proliferation with IC50 of 2.2 uM.

2170836-81-2
DC22171 MX107

MX107 is a novel potent survivin inhibitor, effectively suppresses MDA-MB-231 cells proliferation with IC50 of 3.1 uM.

2170102-50-6
DC21925 MY10

MY10 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation.

2204270-73-3
DC21926 MY33-3

MY33-3 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation.

2204280-41-9
DC9138 Mycophenolate Mofetil

Mycophenolate mofetil is a prodrug for mycophenolic acid, a potent inhibitor of inosine monophosphate dehydrogenase (IC50 = 11 nM). Inhibition of this enzyme blocks de novo GTP generation as well as RNA and DNA synthesis in lymphocytes. In this way, mycop

128794-94-5
DCAPI1127 Mycophenolic (Mycophenolate)

Mycophenolic (Mycophenolate)

24280-93-1
DC21927 Myokinasib

Myokinasib is a mixed-type, selective inhibitor of Myosin Light Chain Kinase 1 (MLCK1) with IC50 of 7.9 uM, can bind to the free enzyme and the enzyme-substrate complex.

DC20469 myomiRs-IN-1

myomiRs-IN-1 is a small-molecule probe that selectively inhibits myogenic microRNAs (myomiRs) including miR-1, miR-133a, and miR-206.

1392224-59-7
DC21360 MZ1 Featured

MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4.

1797406-69-9
DC22172 MZH29

MZH29 is a novel potent, selective, orally active type II FLT3 inhibitor with IC50 of 9 nM and 7 nM against FLT3-WT and FLT3-ITD, respectively.

2089590-80-5
DC8428 Lomitapide Mesylate

N-(2,2,2-trifluorethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide methanesulfonate

202914-84-9
DC23254 N.41

N.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM).

357441-99-7
DC8271 NSC-41589 Featured

N-[2-(methylsulfanyl) phenyl]acetamide.

6310-41-4
DC21107 N1-hexyl-N5-benzyl-biguanide mesylate

N1-hexyl-N5-benzyl-biguanide mesylate (HBB) is a potent and specific inhibitor of CYP3A4 AA epoxygenase activity with IC50 of 9.5 uM for inhibition of CYP3A4-mediated (±)-14,15-EET synthesis.

1834584-89-2
DC10359 N2-Methylguanine

N2-Methylguanine is a modified nucleoside. N2-Methylguanine is an endogenous methylated nucleoside found in human fluids.

10030-78-1
DC9543 N3PT

N3PT(N3-pyridyl thiamine) is a potent and selective transketolase(TK) inhibitor (IC50= 22 nM for Apo-TK) both in vitro and in vivo.

13860-66-7
DC10154 N6-(2-Phenylethyl)adenosine

N6-(2-Phenylethyl)adenosine is a selective A1 adenosine receptor agonist.

20125-39-7
DC23617 NAB-14 Featured

NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors; inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons.

1237541-73-9
DC8980 Nabumetone

Nabumetone(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.

42924-53-8
DC21358 N-acetyl lysyltyrosylcysteine amide Featured

N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation.

1287585-40-3
DC23924 N-Acetyl-Calicheamicin Featured

N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic.

108212-76-6
DC20470 NAcM-COV

NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays.

2089293-81-0
DC20038 NAcM-OPT Featured

NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction.

2089293-61-6
DC21444 Nacubactam Featured

Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial.

2007923-17-1
DC9619 Nafamostat (mesylate) Featured

Nafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant,showed highly potent activity against COVID-19(SARS-COV-2).

82956-11-4
DC23132 Nalfurafine hydrochloride Featured

Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively).

152658-17-8
DC23102 Nalfurafine Featured

Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively).

152657-84-6
DCAPI1173 Nalidixic acid (NegGram)

Nalidixic acid (NegGram)

389-08-2
DC20016 Naloxegol Featured

Naloxegol is a CYP3A4 enzyme inhibitor, is a peripherally-selective opioid antagonist, for the treatment of opioid-induced constipation.

854601-70-0
DC8492 Naloxegol Oxalate(NKTR-118) Featured

Naloxegol is the first oral peripherally acting mu opioid receptor antagonists for opioid-induced constipation.

1354744-91-4
DC8407 Naloxone HCl Dihydrate Featured

Naloxone HCl Dihydrate is an opioid inverse agonist drug used to counter the effects of opiate overdose.

51481-60-8
DC20031 NAMPT inhibitor-linker 1

NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressin

2241019-57-6
DC20032 NAMPT inhibitor-linker 2

NAMPT inhibitor-linker 2 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressin

2241014-82-2
DC22632 NAN-190 hydrobromide

NAN-190 is a 5-HT1A receptor antagonist with Ki of 0.6 nM.

115338-32-4
DC10266 Nandrolone decanoate Featured

Nandrolone Decanoate is a mild form of an anabolic steroid.

360-70-3
DC10228 Nandrolone

Nandrolone is a synthetic, anabolic steroid analog of testosterone.

434-22-0
DCAPI1368 Naphyrone (O-2482)

Naphyrone (O-2482)

850352-53-3
DC22531 Naquotinib

Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)).

1448232-80-1
DC22526 Naquotinib mesylate

Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)).

1448237-05-5
DC20700 Naronapride

Naronapride (ATI-7505) is a potent, selective and orally active 5-HT4 receptor agonist with Ki of 1.4 nM.

860174-12-5
DC21361 N-aryl benzimidazole

N-aryl benzimidazole (NAB) is a small molecule that strongly and selectively protects diverse cell types from α-syn toxicity, promotes endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4 in wild-type yeast cells..

422554-26-5
DC23157 Naspm trihydrochloride Featured

Naspm is a selective antagonist of Ca2+-permeable AMPA receptors, blocks GluR2-lacking AMPARs, suppresses current responses induced by kainate in type II neurons with IC50 of 0.33 uM.

1049731-36-3
DCAPI1337 Natamycin(Pimaricin)

Natamycin(Pimaricin)

7681-93-8
DC9063 Nateglinide

Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).

105816-04-4
DCAPI1056 Nattokinase Featured

Nattokinase, Natto fermentation is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases.

133876-92-3
DC26021 6,8(2H,7H)-Isoquinolinedione,7-(acetyloxy)-5-chloro-3-(3,5-dimethyl-1,3-heptadienyl)-7-methyl- (9CI) Featured

Natural product derived from fungal source.

34695-81-3
DC20025 Nav1.7-IN-3

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration.

1788872-06-9
DC11971 NAV-2729(Grassofermata) Featured

NAV 2729 (NAV2729) is a chemical potentiator for mRNA-LNPs, increasing the delivery efficiencies of mRNA-LNPs in vitro and in vivo. NAV 2729 (NAV2729) is a novel, direct and selective small molecule inhibitor of small GTPase ARF6 with IC50 of 1.5 uM in nucleotide exchange assays.

419547-11-8
DC20472 Naxillin Featured

Naxillin is the first non-auxin-like molecule that promotes root branching, activates a subset of auxin-induced transcripts, including AUX/IAA, SAUR and PIN families; induces auxin response in the basal meristem; represents a valuable tool to further decipher the molecular networks involved in lateral root branching.

301176-96-5
DC21362 NBC19

NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM..

2068818-75-5
DC7209 NBI42902

NBI-42902 is a potent inhibitor of peptide radioligand binding to the human GnRH receptor (K(i) = 0.56 nm).

352290-60-9
DC23638 NBQX disodium

NBQX disodium is the water soluble disodium salt of NBQX, which is a potent, selective and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.15 uM.

479347-86-9
DC21364 NC-001 Featured

NC-001 (NC 001, NC001, az-NC-001) is a potent, specific, cell-permeable inhibitor of immunoproteasome caspase-like sites (β1i and β1), does not correlate with inhibition of chymotrypsin-like sites..

1237540-68-9
DC21366 NC-043

NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association.

1053172-87-4
DC22316 NCC007 Featured

NCC007 is a novel CKIα and CKIδ dual inhibitor. NCC007 that showed stronger period effects (0.32 μM for 5 h period lengthening) in a cellbased circadian assay.

DC23377 NCD-25

NCD-25 is a novel potent, selective LSD1 inhibitor with IC50 of 0.48 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO..

1456972-46-5
DC23353 NCD-38

NCD-38 is a novel potent, selective LSD1 inhibitor with IC50 of 0.59 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO (IC50>100 uM).

2078047-42-2
DC21369 NCGC 00067819 Featured

NCGC 00067819 is a small molecule compound that potentiates CREB signaling with EC50 of 16 nM in the primary screen and 79 nM in the CHO CRE-β-lactamase confirmation assay.

847163-23-9
DC23699 NCGC00071837

NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11.

578747-98-5
DC21372 NCGC00185684

NCGC00185684 (ML154) is a potent, selective, brain penetrant NPSR (Neuropeptide S receptor.

1345964-89-7
DC10476 NCGC00244536 Featured

NCGC00244536 is a potent KDM4A inhibitor with an IC50 of 10 nM.

2003260-55-5
DC23741 NCT-502

NCT-502 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3.7 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.

1542213-00-2
DC10486 NCT-503 Featured

NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 µM.

1916571-90-8
DC20004 NCT-506 Featured

NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM.

2231098-99-8
DC21387 NCX-4016

NCX-4016 (Nitroaspirin.

175033-36-0
DC9810 ND-646 Featured

ND-646(ND646) is a small-molecule allosteric inhibitor of acetyl-CoA carboxylase (ACC).

1434639-57-2
DC23681 ND-654 (ND654)

ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively.

1434641-55-0
DC10302 N-deacetylated BMS-202

N-deacetylated BMS-202 is the deacetylated of BMS-202. BMS-202 is an inhibitor of the PD-l/PD-Ll interaction, mainly used for cancer treatment.

2310135-18-1
DC10438 N-Desmethylclozapine Featured

N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor.

6104-71-8
DC21374 NDT 9513727

NDT 9513727 is a potent, selective and orally bioavailable C5a receptor inverse agonist with IC50 of 11.6 nM in radioligand binding assay.

439571-48-9
DC12348 NE 10790 (3-PEHPC) Featured

NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

152831-36-2
DC12511 Nebicapone

Nebicapone (BIA 3-202, BIA3-202) is a potent, long-acting, reversible and competitive peripheral inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 3.7 nM for rat brain COMT, much less potent for liver COMT with IC50 of 696 nM.

274925-86-9
DC10551 Necrostatin 2 racemate Featured

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

852391-15-2
DC2084 Necrostatin-1 Featured

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.

4311-88-0
DC23292 Necrox-5 methanesulfonate Featured

NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.

1383718-29-3
DC21375 NecroX-2 Featured

NecroX-2 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI.

1120333-38-1
DCAPI1393 Nedaplatin (Aqupla) Featured

Nedaplatin (Aqupla) is a derivative of cisplatin for inhibition of tumor colony forming units with IC50 of 28.5 μg/mL.

95734-82-0
DC20473 NEDD8 inhibitor M22 Featured

NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor.

864420-54-2
DC9569 Nefazodone (hydrochloride) Featured

Nefazodone hydrochloride is an antidepressant drug.

82752-99-6
DC23246 Nef-IN-B9

Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM.

1473404-51-1
DCAPI1513 Nefopan hydrochloride

Nefopanhydrochloride

23327-57-3
DC8194 PP3 Featured

Negative control for the Src kinase inhibitor PP2.

5334-30-5
DC8290 (S)-PFI-2 HCl Featured

Negative control of (R)-PFI 2 hydrochloride. Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC50 = 1 μM) compared to the active enantiomer.

1627607-88-8
DC12465 NEK6 inhibitor 8 Featured

NEK6 inhibitor 8(ZINC05007751) is a novel inhibitor of the NIMA-related kinase NEK6 with IC50 of 3.4 uM, compound 8 is very selective against NEK1 and NEK6, while no signifcant activity was observed against NEK2, NEK7, and NEK9.

591239-68-8
DC20743 Neladenoson dalanate

Neladenoson dalanate is a potent, selective, orally acitve partial adenosine A1 receptor (A1AR) agonist (EC50=0.1 nM) for the treatment of chronic heart failure..

1239309-58-0
DC20744 Neladenoson dalanate hydrochloride

Neladenoson dalanate is a potent, selective, orally acitve partial adenosine A1 receptor (A1AR) agonist (EC50=0.1 nM) for the treatment of chronic heart failure..

1239235-25-6
DC4129 Arranon Featured

Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.

121032-29-9
DC22175 NEO214

NEO214 (NEO-214) is a novel, BBB-permeable rolipram-perillyl alcohol conjugate, shows effectivity against both TMZ-sensitive and TMZ-resistant glioma cells (T98G IC50=40 uM).

1361198-80-2
DC23087 Neoandrographolide Featured

Neoandrographolide has antiradical, anti-inflammatory,and hypolipidemic effects, it protects the cardiovascular without significant liver damage. Neoandrographolide as chemosensitizer in S-Jurkat and X chromosome-linked inhibitor of apoptosis protein (XIA

27215-14-1
DC23057 Nestorone

Nestoron2 (ST1435, Elcometrine) is a 19-norprogesterone derivative and steroidal progestin which is used as a hormonal contraceptive, a high-affinity agonist of the progesterone receptor..

7759-35-5
DC22636 Netarsudil dihydrochloride Featured

Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2.

1253952-02-1
DC9353 Netilmicin (sulfate)

Netilmicin Sulfate is an active aminoglycoside antibiotic against most Gram-negative and some Gram-positive bacteria, including certain strains resistant to gentamicin.

56391-57-2
DC8100 Netupitant

Netupitant is a highly potent and selective, orally active neurokinin-1 receptor antagonist with Ki of 0.95 nM.

290297-26-6
DC23275 NEU-1953(NEU1953)

NEU-1953 (NEU1953) is a potent inhibitor of P. falciparum with EC50 of 0.43 uM (T. brucei), demonstrates improved ADME profile over the NEU-961..

2218480-85-2
DC5131 Neuropathiazol Featured

Neuropathiazol selectively induces neuronal differentiation of primary hippocampal neural progenitor cells. It is more potent and selective compared to retinoic acid. Also suppresses astrocyte differentiation.

880090-88-0
DC12238 Neurotoxin Inhibitor

Neurotoxin Inhibitor is a neurotoxin inhibitor.

951571-70-3
DC23016 Nexinhib 20

Nexinhib 20 is a novel small molecule neutrophil exocytosis inhibitor (IC50=0.33 uM) that specifically inhibits Rab27a-JFC1 binding (IC50=2.6 uM) but does not interfere with the interaction of other Rab GTPases and effectors.

1162656-24-7
DC12660 NFAT Inhibitor-1 Featured

NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.

249537-73-3
DC12176 NFAT Transcription Factor Regulator Featured

NFAT Transcription Factor Regulator is an IL-2 synthesis inhibitor with an IC50 of 182 nM.

245747-71-1
DC23081 NFPS

NFPS (ALX-5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2.

405225-21-0
DC8076 NG 52 (Compound 52 ) Featured

NG 52 (Compound 52) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).

212779-48-1
DC21380 NGD-4715

NGD-4715 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1), has anxiolytic, antidepressant and anorectic effects..

476322-70-0
DC11281 NGI-1 (ML414) Featured

NGI-1 (ML414) is a potent, cell-permeable oligosaccharyltransferase (OST) inhibitor with IC50 of 1.1 uM.

790702-57-7
DC11200 NGI-1 derivative C-19

NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A.

924471-88-5
DC8525 NIBR-17 Featured

NIBR-17 is a pan class I PI3K inhibitor with IC50 values of 1, 9.2, 9 and 20 nM respectively for PI3Kapha - delta.

944396-88-7
DC21742 NIBR-3049

NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively..

1260181-14-3
DC7977 Nicaraven Featured

Nicaraven is an antivasospastic substance.

79455-30-4
DC25090 Nicardipine

Nicardipine(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage..

55985-32-5
DC9068 Niclosamide

Niclosamide(BAY2353) is used for the treatment of most tapeworm infections by inhibiting DNA replication.

50-65-7
DC21243 Nidufexor(LMB-763) Featured

Nidufexor (LMB763, LMB-763) is a novel potent farnesoid X receptor (FXR) agonist for the treatment of non-alcoholic steatohepatitis (NASH) and hepatobiliary disorders.

1773489-72-7
DC9079 Nifedipine

Nifedipine(Adalat), a potent vasodilator agent with calcium antagonistic action.

21829-25-4
DCAPI1571 Nifuratel

Nifuratel

4936-47-4
DC12297 Nigakinone

Nigakinone is one of the most abundant alkaloids responsible for the major pharmacological activities of Kumu.

18110-86-6
DC10028 NIH-12848 Featured

NIH-12848 (NCGC00012848-02) is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, was explored as a tool for investigating this enigmatic, low activity,

959551-10-1
DC4192 Nilutamide

Nilutamide is an antiandrogen medication used in the treatment of advanced stage prostate cancer.

63612-50-0
DC9379 Nilvadipine

Nilvadipine(FR34235) is a calcium channel blocker for treatment of hypertension.

75530-68-6
DC9052 Nimesulide

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

51803-78-2
DC7758 Nimorazole Featured

Nimorazole is a nitroimidazole anti-infective.

6506-37-2
DCAPI1251 Nitazoxanide (Alinia, Annita) Featured

Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM).

55981-09-4
DC21383 NITD-304

NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv.

1473450-60-0
DC21384 NITD-349

NITD-349 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 23 nM against M tuberculosis H37Rv.

1473450-62-2
DC21385 NITD-564

NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.

1614262-75-7
DC21386 NITD-916

NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb.

1614262-83-7
DC9561 Nitisinone Featured

Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.

104206-65-7
DC9085 Nitrendipine

Nitrendipine is a calcium channel blocker with marked vasodilator action.

39562-70-4
DC21388 NJK14047

NJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α, suppresses RSV and influenza A virus replication by inhibiting virus-induced p38 MAPK activation.

1800576-41-3
DC20916 NKH 477 hydrochloride Featured

NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase.

138605-00-2
DC9786 NKP-1339 Featured

NKP-1339 is the first-in-class ruthenium-based anticancer drug in clinical development against solid cancer and has recently been studied successfully in a phase I clinical trial.

197723-00-5
DC5172 NLG919(GDC-0919) Featured

NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.

1402836-58-1
DC26132 NLRP3 Inflammasome Inhibitor I

NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.

16673-34-0
DC22177 NLY01

NLY01 (NLY-01, GLP1R agonist NLY01) is a potent, brain-penetrant long-acting GLP1R agonist, protects against the loss of dopaminergic neurons and behavioral deficits in the α-synuclein preformed fibril (α-syn PFF) mouse model of sporadic Parkinson's disea

DC11134 NMac1

NMac1 (Nm23 activator 1) is a small molecule activator of Nm23/NDPK, directly binds to Nm23-H1 and activates NDPK activity of recombinant Nm23-H1 with EC50 of 10.7 uM.

1332290-68-2
DC20105 NMDAR antagonist 1 Featured

NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist.

2220162-06-9
DC8829 Betahistine EP Impurity C(NSC19005) Featured

N-Methyl-N,N-bis(2-pyridylethyl)amine is used as a reagent in the preparation of copper pyridylmethylethylenediamine dicyanamido polymeric complexes.

5452-87-9
DC7212 NMS-873 Featured

NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 20 nM (Wild Type, 1 mM ATP).

1418013-75-8
DC21390 NMS-P293

NMS-P293 is a novel potent and selective PARP-1 inhibitor possessing >200-fold selectivity versus PARP-2.

DC23556 NMS-P645

NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively.

1482518-95-5
DC8445 NMS-P937 (NMS1286937) Featured

NMS-P937 (NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Phase 1.

1034616-18-6
DC21224 NMT1 inhibitor B13

NMT1 inhibitor B13 (LCL4) is a myristoylCoA analog that acts as a small molecule inhibitor of NMT1 with IC50 of 77.6 uM, blocks Src myristoylation and Src localization to the cytoplasmic membrane.

35922-06-6
DC21391 NNC 05-2090 hydrochloride Featured

NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.

184845-18-9
DC22893 NNC-0640

NNC-0640 (NNC 0640, NNC0640) is a potent, selective glucagon receptor (GCGR) negative allosteric modulator with IC50 of 69.2 nM.

307986-98-7
DC21392 NNC-711 Featured

NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.

145645-62-1
DC4204 Nocodazole Featured

Nocodazole inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. Enhances homology-directed repair (HDR) efficiency 9 to 31% (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.

31430-18-9
DC4111 Nolatrexed (AG-337) Featured

Nolatrexed (AG-337), inhibits purified recombinant human thymidylate synthase (TS) with a Ki of 11 nM, and displays non-competitive inhibition kinetics. It was further shown to inhibit cell growth in a panel of cell lines of murine and human origin, displ

152946-68-4
DC10549 Nomifensine maleate Featured

Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.

32795-47-4
DC9342 Noopept

Noopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.

157115-85-0
DCAPI1558 Oxiracetam

Nootropic agent shown to exhibit learning and memory improvement and cognitive function impairment prevention. Mechanism of action has not been quantified, but current theories suggest a modulation of glutamatergic and cholinergic neurotransmissions with

62613-82-5
DC8848 Nosiheptide

Nosiheptide is a bicyclic thiopeptide antibiotic produced by several species of actinomycetes, notably Streptomyces.

56377-79-8
<Prev1...2728293031...127Next>