| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC10018 | Atrasentan hydrochloride Featured | Atrasentan Hcl(A-147627) is an endothelin antagonist receptor (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer. |
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| DC22004 | ATV399 | ATV399 (ATV-399) is a novel small molecule that dose-dependently reduces the cleaved caspase9 levels with IC50 of 3.3 uM, inhibits dimerization of iNOS. |
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| DC20114 | ATWLPPR Peptide TFA | ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis. ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes. |
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| DC23401 | AU1 | AU1 (GSK 1379725A) is the first selective small molecule inhibitor of BPTF bromodomain (bromodomain PHD finger transcription factor) with Kd of 2.8 uM in a cell-based reporter assay, shows no binding activity for Brd4. |
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| DC10552 | AU1235 Featured | AU1235 is an adamantyl urea inhibitor of Mycobacterium tuberculosis. |
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| DC21865 | Aumitin Featured | Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively, targets mitochondrial complex I. |
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| DC12428 | AUNP-12 Featured | AUNP-12 (Aurigene-012) is a PD-1 inhibitor peptide, blocks the PD-1/PD-L1, PD-1/PD-L2 and PD-L1/CD80 pathways. |
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| DC26036 | Aurantiamide acetate | Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic flux. |
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| DC20312 | Aurintricarboxylic acid | Aurintricarboxylic acid (ATA) is a potent small molecule inhibitor of RISC loading with IC50 of 0.47 uM, inhibits RISC activity against transiently expressed reporters and endogenous genes. |
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| DC10138 | Auristatin E Featured | Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates. |
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| DC7964 | Aurora A Inhibitor I Featured | Aurora A inhibitor I is a selective Aurora A inhibitor (Aurora A: IC50=0.0034 μM; Aurora B IC50=3.4 μM), (B/A ratio=1000). |
|
| DC20037 | Aurora inhibitor 1 | Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively. |
|
| DC26118 | AKI-7169(Aurora Kinase Inhibitor III) Featured | Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM). |
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| DC11999 | AUT-1 Featured | AUT-1 is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively. |
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| DC10548 | Auten-99 Featured | Auten-99 is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14), acrossing the blood-brain barrier and exerting potent neuroprotective effects. |
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| DC10461 | Autophinib Featured | Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34. |
|
| DC21866 | Autotaxin inhibitor 12 | Autotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays. |
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| DC20701 | Autotaxin inhibitor compound 1 | Autotaxin inhibitor compound 1 (Autotaxin-IN-1) is a potent, selective, orally bioavailable inhibitor of autotaxin with IC50 of 2.2 nM in ex vivo human whole blood assay, does not inhibit related proteins ENPP1 and ENPP7. |
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| DC22219 | Auxin agonist RN3 | Auxin agonist RN3 (RubNeddin 3) is a potent, selective auxin agonist that induces specific AUX/IAA protein degradation to modulate plant development. |
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| DC22220 | Auxin agonist RN4 | Auxin agonist RN4 (RubNeddin 4) is a potent, selective auxin agonist that induces specific AUX/IAA protein degradation to modulate plant development. |
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| DC5202 | Luminespib (NVP-AUY922) Featured | AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 1/2. |
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| DC8253 | AV-412(MP-412) | AV-412(MP-412) is a potent dual inhibitor of EGFR and ErbB2(IC50=19 nM) tyrosine kinases, including the mutant EGFR(L858R IC50=0.51 nM, T790M IC50=0.79 nM); inhibits autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. |
|
| DC8799 | Avanafil(TA-1790) Featured | Avanafil(TA-1790) is a potent and highly selective phosphodiesterase-5(PDE-5) inhibitor(IC50=5.2 nM) for erectile dysfunction; lower selectivity against PDE1, PDE6, and PDE11. |
|
| DC22012 | Avanbulin | Avanbulin (BAL27862, BAL-27862) is a novel microtubule-destabilizing agent that potently inhibits tubulin assembly at 37°C with IC50 of 1.4 uM in tubulin-binding assays. |
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| DC1094 | Avasimibe Featured | Avasimibe inhibits ACAT and CYP2C9 with IC50 of 3.3 μM and 2.9 μM, respectively. |
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| DC20703 | AVE-0118 | AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency. |
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| DC10732 | Anavex-2-73 free base (Blarcamesine) Featured | AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease |
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| DC12715 | AVG-233 | AVG-233 (AVG233) is a potent, allosteric inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) complex, demonstrates nanomolar activity against both laboratory-adapted RSV strains and clinical RSV isolates (EC50=34-79 nM). |
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| DC8351 | Avibactam sodium Featured | Avibactam sodium(NXL-104) is a non-β-lactam β-lactamase inhibitor antibiotic. |
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| DC10009 | Avitinib free base Featured | Avitinib is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. |
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