| DCAPI1559 |
Calcifediol
Featured
|
Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM). |
|
| DCAPI1415 |
Calcipotriol(Calcipotriene)
Featured
|
Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor. |
|
| DC10327 |
Calcitonin salmon
Featured
|
Calcitonin, Salmon is a calcium regulating hormone secreted from mammalian thyroid parafollicular cells and in non-mammalian species from the ultimobranchial gland. |
|
| DCAPI1150 |
Calcitriol (Rocaltrol)
Featured
|
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist. |
|
| DCAPI1351 |
Calcium levofolinate (Calcium Folinate) |
Calcium levofolinate (Calcium Folinate) |
|
| DC12253 |
Calcium polystyrene sulfonate (Poly(styrenesulfonic acid) calcium salt) |
Calcium polystyrene sulfonate is an ion-exchange resin used for reducing blood levels of potassium. Calcium polystyrene sulfonate is used to treat hyperkalemia in patients with chronic kidney disease (CKD). |
|
| DC9386 |
Calcium-Sensing Receptor Antagonists I |
Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. |
|
| DC20857 |
Calhex-231
Featured
|
Calhex-231 is a potent negative allosteric modulator of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM. |
|
| DC11275 |
Calicheamicin
Featured
|
Calicheamicin, also known as Calicheamicin gamma(1,I) or Calichemicin gamma1, is an potent enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora. Calicheamicin targets DNA and cause strand scission. Calicheamicin binds with DNA in the minor groove, wherein it then undergos a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1,4-didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA, which ultimately leads to strand scission. The specificity of binding of calicheamicin to the minor groove of DNA is due to the aryltetrasaccharide group of the molecule. |
|
| DC20329 |
Calindol hydrochloride |
Calindol hydrochloride is a calcimimetic acting agent and positive allosteric modulator (agonist) of CaSR with EC50 of 0.31 uM (stimulated 3H IP accumulation in CHO cells at 2 mM Ca2+). |
|
| DC20021 |
Calmidazolium chloride (R 24571)
Featured
|
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively. Also in anti-cancer re |
|
| DC7095 |
W-7 hydrochloride
Featured
|
Calmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM) and myosin light chain kinase (IC50 = 51 μM). |
|
| DC7967 |
calpeptin
Featured
|
calpeptin is Ca2+-dependent protease,calpain inhibitor |
|
| DC22045 |
CAM4066 |
CAM4066 (CAM-4066) is a potent and selective CK2α inhibitor with Kd of 0.32 uM and IC50 of 0.37 uM, shows significantly improved selectivity compared to other CK2α inhibitors. . |
|
| DC22046 |
CAM4712 |
CAM4712 (CAM-4712) is a potent and selective CK2α inhibitor with IC50 of 7 uM, exhibits cell growth inhibition in HCT116 cell line with IC50 of 10 uM. |
|
| DC8730 |
Cambendazol
Featured
|
Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle. |
|
| DC10744 |
Cambinol
Featured
|
Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively. |
|
| DC20330 |
CAMKK2 inhibitor 4t |
CAMKK2 inhibitor 4t is a potent, selective, orally available, brain-penetrant CAMKK2 inhibitor with pIC50 of 8.5. |
|
| DC10377 |
Campesterol |
Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects. |
|
| DC6701 |
Camptothecine |
Camptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. |
|
| DC20859 |
CAN-508
Featured
|
CAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM). |
|
| DC7825 |
Canagliflozin hemihydrate |
Canagliflozin 0.5 H2O(JNJ 28431754; TA 7284) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM, exhibits 413-fold selectivity over hSGLT1. |
|
| DC3111 |
Canagliflozin
Featured
|
Canagliflozin is a highly potent and selective SGLT2 inhibitor for CHO-hSGLT2, CHO-rSGLT2 and CHO-mSGLT2 with IC50 of 4.4 nM, 3.7 nM and 2 nM, respectively. |
|
| DC9185 |
Candesartan cilexetil
Featured
|
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. |
|
| DC9142 |
Candesartan |
Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM. |
|
| DC8553 |
Canertinib
Featured
|
Canertinib (CI-1033) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Phase 3. CI-1033 shows excellent potency for irreversible inhibition of erbB2 autophosphorylation in MDA-MB |
|
| DC3138 |
Canertinib dihydrochloride
Featured
|
Canertinib dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. |
|
| DC22425 |
Cangrelor sodium
Featured
|
Cangrelor (AR-C69931MX) is a potent, selective P2T/P2Y12 receptor antagonist with IC50 of 0.4 nM against ADP-induced aggregation of human platelets. |
|
| DC7005 |
Cangrelor free acid
Featured
|
Cangrelor is a P2Y12 inhibitor, and was approved in June 2015 as an antiplatelet drug for intravenous application. Cangrelor is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggrega |
|
| DC4154 |
Capecitabine
Featured
|
Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. |
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