| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC10539 | POL1 inhibitor(POL1-IN-1) Featured | CAS 1822358-25-7 |
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| DC11250 | Casein Kinase inhibitor A51 Featured | Casein Kinase inhibitor A51 (CKIα inhibitor A51) is a novel pan-specific CKI (CSNK1) inhibitor (Kd=0.5-20 nM, CKIα Kd=5.3 nM) that co-targets the transcriptional kinases CDK7 and CDK9, with hardly inhibition of CDK8, CDK13, CDK11a, CDK11b, and CDK19; target both CDK7 and CDK9 with low nM Kd values; induces leukemia cell apoptosis at <160 nM, in correlation to the capacity to stabilize p53; shows high and selective sensitivity against leukemic CFUs in colony-forming unit (CFU) assay, without effect on normal hematopoietic CFUs; blocking CKIα together with CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, induce apoptosis, abolishes the expression of MYC, MDM2, and the anti-apoptotic oncogene MCL1; demonstrates therapeutic efficacy with preserved hematopoiesis and leukemia cure potential in AML mouse models. |
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| DC11251 | Casein Kinase inhibitor A86 | Casein Kinase inhibitor A86 (CKIα inhibitor A86) is a novel pan-specific CKI (CSNK1) inhibitor (Kd=1-10 nM, CKIα Kd=9.8 nM) that co-targets the transcriptional kinases CDK7 and CDK9, with hardly inhibition of CDK8, CDK13, CDK11a, CDK11b, and CDK19. |
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| DC8013 | CASIN Featured | CASIN is a Cdc42 GTPase inhibitor (IC50 = 2 μM). |
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| DC22402 | Casopitant | Casopitant (GW679769) is a potent, centrally-acting neurokinin 1 (NK1) receptor antagonist (pKi=9.48) with antidepressant and antiemetic activities. |
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| DC22403 | Casopitant mesylate Featured | Casopitant (GW679769) is a potent, centrally-acting neurokinin 1 (NK1) receptor antagonist (pKi=9.48) with antidepressant and antiemetic activities. |
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| DCAPI1497 | Cancidas Featured | Caspofungin is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acts by inhibition of the synthesis of β (1,3)-D-glucan, an e |
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| DC22047 | CAT639 | CAT639 is an improved analog of ATV399 that exhibits improved β-cell viability and insulin secretion in the rat insulin-producing INS1E cells and primary rat dispersed islet cells, inhibits dimerization of iNOS. |
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| DCAPI1130 | Catharanthine | Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 µM. |
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| DC22206 | Cathepsin B inhibitor RC1 | Cathepsin B inhibitor RC1 is a small-molecule that blocks the process of anthrax lethal toxin (LT) cytotoxicity, inhibits enzymatic activity of host cathepsin B that mediates the escape of toxins into the cytoplasm from late endosomes. |
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| DCAPI1119 | Cathepsin Inhibitor 1 Featured | Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
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| DC8482 | CAY10415(MSDC-0160) Featured | CAY10415 is a potent, antidiabetic drug of the TZD structural class. |
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| DC10847 | CAY10441（RO1138452） Featured | CAY10441 is a Selective prostacyclin IP receptor antagonist. |
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| DC10903 | CAY10465 Featured | CAY10465 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor agonist, with a Ki of 0.2 nM. |
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| DC10516 | LW6(CAY10585) Featured | CAY10585 prevented HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 µM, respectively. |
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| DC12099 | CAY10595 | CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM. |
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| DC10579 | CAY 10602 Featured | CAY10602 is a SIRT1 activator. |
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| DC8036 | CAY10603 Featured | CAY10603 is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. |
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| DC7738 | CAY10683(Santacruzamate A) Featured | CAY10683 is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs. |
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| DC20607 | Cazpaullone | Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM). |
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| DC4160 | CB-03-01 Featured | CB-03-01 is a steroidal ester, androgen antagonist derived from 11-deoxycortisone, which tightly mimics the profile of an ideal anti-androgen for topical use. |
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| DC11709 | CB-1158 | CB-1158 (INCB-01158) is a potent, selective, oral available Arginase inhibitor with IC50 of 98 nM. |
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| DC8840 | CB-5083 Featured | CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . |
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| DC22986 | CB5305630 | CB5305630 is a potent and noncompetitive IRE1 RNase inhibitor with IC50 of 60 nM in the FRET-derepression assay. |
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| DC20861 | CB-618 | CB-618 (CB 238618) is a novel non-β-lactam β-lactamase inhibitor that potentiates meropenem MIC values against clinical Enterobacteriaceae isolates. |
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| DC20862 | CB-618 sodium salt | CB-618 (CB 238618) is a novel non-β-lactam β-lactamase inhibitor that potentiates meropenem MIC values against clinical Enterobacteriaceae isolates. |
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| DC20052 | CB-6644 Featured | CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM. |
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| DC20863 | CB-6673567 | CB-6673567 is a potent, selective Adenylyl Cyclase 1 (AC1) inhibitor with IC50 of 77 uM, displays a 2- to 4-fold isoform selectivity over AC6. |
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| DC10449 | CB7921220 Featured | CB7921220 is an inhibitor of Adenylyl Cyclase isoform-1 (AC1) and isoform-6 (AC6). |
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| DC8042 | CB-839(Telaglenastat) Featured | CB-839 is a potent, selective, reversible and orally bioavailable inhibitor of human glutaminase. |
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