| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC23844 | DDR1 inhibitor 7rh | DDR1 inhibitor 7rh is a potent, selective, ATP-competitive, orally available Discoidin domain receptor 1 (DDR1) inhibitor with IC50 of 6.8 nM in cell-free kinase assays. |
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| DC7398 | DDR1-IN-1 Featured | DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with IC50/EC50 of 105 nM/87 nM; 4-fold less potent for DDR2 (IC50= 413 nM). |
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| DC23857 | DDR2-IN-5 | DDR2-IN-5 is a potent, dual DDR2/SRC inhibitor with IC50 of 56/12 nM, potently suppresses DDR2 mutated cell lines HCC-366 and NCI-H2286 with IC50 of 0.44 uM and 0.29 uM.. |
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| DC12560 | DDR-TRK-1 | DDR-TRK-1 (DDR1 inhibitor 6j) is a potent, selective selective DDR1 inhibitor with IC50 of 9.4 nM, also potently inhibits TRK family with IC50 of 18-100 nM. |
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| DC10111 | Debio 0617B | Debio 0617B has been developed as a first-in-class kinase inhibitor with a unique profile targeting phospho-STAT3 (pSTAT3) and/or pSTAT5 in tumors through combined inhibition of JAK, SRC, ABL, and class III/V receptor tyrosine kinases (RTK). |
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| DC7390 | CUDC-305(DEBIO 0932) Featured | Debio 0932 ( CUDC-305 ) is a novel heat shock protein 90 (HSP90) inhibitor trong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L) . |
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| DC8171 | Decernotinib (VX-509,adelatinib) Featured | Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays. |
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| DC4193 | Decitabine Featured | Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively. |
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| DC12144 | Decursin ((+)-Decursin) Featured | Decursin is an anticancer agent, with potential anti-inflammatory activity. |
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| DC7695 | Defactinib (VS-6063, PF-04554878) Featured | Defactinib is a potent, selective, and orally active FAK inhibitor with demonstrated tolerability and preliminary clinical activity working as a single agent as well as in combination with paclitaxel. |
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| DC10100 | Defactinib hydrochloride Featured | Defactinib is a potent, selective, and orally active FAK inhibitor with demonstrated tolerability and preliminary clinical activity working as a single agent as well as in combination with paclitaxel. |
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| DC10822 | Defensamide(MHP) Featured | Defensamide, also known as MHP and methyl caprooyl tyrosinate, is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC. |
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| DCAPI1107 | Deferasirox (Exjade) Featured | Deferasirox (Exjade) |
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| DC7399 | Deferitrin Featured | Deferitrin (GT-56-252) is the first drug in a class of desferrithiocin-derived hexadentate iron chelators. |
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| DC11332 | Degarelix (acetate) Featured | Degarelix is a synthetic gonadotropin-releasing hormone receptor (GNRHR) antagonist (IC50 = 3 nM in HEK293 cells expressing the human receptor). |
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| DC9337 | Deguelin Featured | Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor effect on several cancers; decrease levels of phosphorylated Akt. |
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| DC5201 | Dehydroepiandrosterone (DHEA) | Dehydroepiandrosterone(DHEA) is a 19-carbon endogenous natural steroid hormone. |
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| DC23727 | Dehydromutactin | Dehydromutactin is a small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 40 nM. |
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| DC12073 | Dehydronitrosonisoldipine | Dehydronitrosonisoldipine is a calcium channel antagonist. |
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| DC8866 | DEL-22379 Featured | DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM. |
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| DC10458 | Delafloxacin（ABT-492） Featured | Delafloxacin (RX-3341, ABT-492) is a fluoroquinolone antibiotic agent. |
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| DC20116 | Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) Featured | Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and |
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| DC7764 | Delamanid (OPC-67683) Featured | Delamanid (OPC-67683) is an experimental drug for the treatment of multi-drug-resistant tuberculosis. |
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| DC8481 | Delanzomib(CEP-18770) Featured | Delanzomib(CEP-18770) is a novel orally-active inhibitor of the chymotrypsin-like activity of the proteasome that down-modulates the nuclear factor-kappaB (NF-kappaB) activity. |
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| DC11352 | Delavirdine (mesylate) | Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively). |
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| DC8897 | Delavirdine | Delavirdine(U 90152) is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI). |
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| DC20772 | Deleobuvir | Deleobuvir (BI-207127, BI207127) is a potent, selective HCV NS5B polymerase inhibitor with IC50 of 50 nM against GT-1 HCV polymerase activity. |
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| DC11890 | Delgocitinib Featured | Delgocitinib (JTE-052, LEO 124249) is a potent, selective, orally active, pan-JAK inhibitor with IC50 of 2.8, 2.6, 13 and 58 nM for JAK1,2,3 and Tyk2, respectively. |
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| DC10612 | Delpazolid (LCB01-0371) Featured | Delpazolid (LCB01-0371) is a new oxazolidinone with cyclic amidrazone. |
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| DC8205 | Deltarasin Featured | Deltarasin is a novel and small molecule inhibitor which can inhibit the KRAS-PDEδ interaction(Kd= 41 nM. binding to PDEδ) and impairs oncogenic KRAS signalling. |
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