| DC7947 |
Ledipasvir
Featured
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Ledipasvir(GS5885) is an inhibitor of the hepatitis C virus NS5A protein. Ledipasvir is an experimental drug for the treatment of hepatitis C. |
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| DC9773 |
LEE011 hydrochloride
Featured
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LEE011 Hcl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. |
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| DC7453 |
Ribociclib (LEE011)
Featured
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LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. |
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| DC9774 |
LEE011 succinate
Featured
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LEE011 succinate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. |
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| DC12387 |
Lefamulin acetate
Featured
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Lefamulin acetate is a pleuromutilin antibiotic that is being developed by Nabriva Therapeutics for the treatment of acute bacterial skin and skin-structure infections. |
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| DC8172 |
Lefamulin(BC-3781)
Featured
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Lefamulin is a semi-synthetic compound that inhibits the synthesis of bacterial protein, which is required for bacteria to grow. |
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| DCAPI1333 |
Leflunomide |
Leflunomide |
|
| DC21231 |
LEI-105 |
LEI-105 is a potent, highly selective, and reversible dual DAGL-α/DAGL-β inhibitor with pIC50 pf 7.5/7.4 respectively. |
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| DC22136 |
LEI 110
Featured
|
LEI110 (LEI－110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6). |
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| DC12562 |
LEM-14
Featured
|
LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM, and that is inactive against the closely related NSD1 and NSD3.. |
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| DC12563 |
LEM-14-1189 |
LEM-14-1189 is a LEM-14 derivative that differentially inhibits the NSDs with in vitro IC50 of 418 μM (NSD1), IC50 of 111 μM (NSD2) and IC50 of 60 μM (NSD3).. |
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| DC8173 |
Lemborexant(E2006)
Featured
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Lemborexant (E-2006) is a dual antagonist of the orexin OX1 and OX2 receptors which is under development for treatment of insomnia. |
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| DCAPI1502 |
Lenalidomide
Featured
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Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. |
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| DC12386 |
Leniolisib (CDZ173)
Featured
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Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor currently in phase II/III clinical trials for the treatment of immunodeficiency disorders. |
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| DC22302 |
Leonurine hydrochloride
Featured
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Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory. |
|
| DC10777 |
Leonurine
Featured
|
Leonurine, a natural alkaloid extracted from Herba leonuri, has been proved to have anti-inflammatory effect. |
|
| DC23882 |
LEQ 506 |
LEQ 506 (NPV-LEQ 506) is a second-generation inhibitor of Smoothened (Smo) with IC50 of 2 nM and 4 nM for human and mouse Smo, respectively. |
|
| DC9186 |
Lercanidipine HCl |
Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class. |
|
| DC8905 |
Lercanidipine
Featured
|
Lercanidipine is a calcium channel blocker of the dihydropyridine class. |
|
| DC5052 |
Lersivirine（UK 453061）
Featured
|
Lersivirine (UK-453061) is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for the treatment of HIV-1 infection. |
|
| DC8731 |
Lesinurad sodium
Featured
|
Lesinurad sodium (RDEA594 sodium) is an once-daily inhibitor of URAT1; URAT1 is a transporter in the kidney that regulates uric acid excretion from the body. |
|
| DC7631 |
Lesinurad (RDEA594）
Featured
|
Lesinurad(RDEA594), once-daily inhibitor of URAT1, is a transporter in the kidney that regulates uric acid excretion from the body. |
|
| DC23569 |
Lesogaberan |
Lesogaberan (AZD-3355) is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM). |
|
| DC22807 |
Lestaurtinib
Featured
|
Lestaurtinib (KT-5555, CEP-701) is a potent, orally active JAK2, FLT3 and TrkA inhibitor with IC50 of 0.9 nM, 3 nM and < 25 nM, respectively. |
|
| DC21731 |
Letaxaban |
Letaxaban (TAK-442, TAK442) is a potent, selective and direct factor Xa (FXa) inhibitor with Ki of 1.8 nM for hFXa, >440-fold selectivity than thrombin and negligible effects on trypsin, plasmin, and tPA. |
|
| DC9798 |
Leteprinim
Featured
|
Leteprinim (Neotrofin, AIT-082) is a hypoxanthine derivative drug with neuroprotective and nootropic effects. |
|
| DC12543 |
Lethal toxin inhibitor DN1 |
Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) wit |
|
| DCAPI1414 |
Letrozole
Featured
|
Letrozole(CGS-20267) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant. |
|
| DC20434 |
Leucettamine B |
Leucettamine B is a potent inhibitor of CLK1 (IC50=15 nM), Dyrk1A (IC50=40 nM), and Dyrk2 (IC50=35 nM) and a moderate inhibitor of CLK3 (IC50=4.5 uM).. |
|
| DC9167 |
Calcium Folinate |
Leucovorin Calcium is a reduced folic acid. |
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