| DC24072 |
LY-2584702 free base
Featured
|
LY2584702 is a potent, selective, ATP-competitive inhibitor of P70 S6 kinase-1 (p70S6K1) with IC50 of 4 nM. |
|
| DC24073 |
LY-2584702 hydrochloride
Featured
|
LY2584702 is a potent, selective, ATP-competitive inhibitor of P70S6 kinase-1 (p70S6K1) with IC50 of 4 nM. |
|
| DC7943 |
LYS6K2(LY2584702) tosylate salt
Featured
|
LY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes. |
|
| DC7103 |
LY2603618(IC-83)
Featured
|
LY2603618(IC-83) is a potent and selective small molecule inhibitor of Chk1 protein kinase activity in vitro (IC50=7 nM) and the first selective Chk1 inhibitor to enter clinical cancer trials. |
|
| DC7993 |
Prexasertib (LY2606368) 2HCl
Featured
|
LY2606368 2Hcl is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase. |
|
| DC10796 |
Prexasertib (LY2606368)
Featured
|
LY2606368 is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase. |
|
| DC7458 |
LY2608204
Featured
|
LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM. |
|
| DC22140 |
LY2623091 |
LY2623091 (LY-2623091) is an orally administered mineralocorticoid receptor antagonist for the treatment of essential hypertension and chronic kidney disease.. |
|
| DC23444 |
LY2624803 |
LY2624803 is a novel potent histamine H1 and 5HT-2A receptor modulator in the pipeline for treating insomnia.. |
|
| DC7665 |
Gandotinib(LY2784544)
Featured
|
LY2784544 is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2. |
|
| DC23510 |
LY2794193
Featured
|
LY2794193 is a highly potent and selective mGlu3 receptor agonist with Ki of 0.93 nM and EC50 of 47 nM, >100-fold selectivity over mGlu2 receptor.. |
|
| DC10815 |
LY2795050
Featured
|
LY2795050 is a novel selective κ-opioid Receptor (KOR) antagonist (IC50=0.72 nM) and has the potential as a PET tracer to image KOR in vivo. |
|
| DC7035 |
Merestinib(LY2801653 dihydrochloride)
Featured
|
LY2801653 2HCl is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM). |
|
| DC8586 |
LY2801653
Featured
|
LY2801653 is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM). |
|
| DC5180 |
LY2811376
Featured
|
LY2811376 is the first orally available non-peptidicβ-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM. |
|
| DC12081 |
LY2828360
Featured
|
LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB2) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling. |
|
| DC8643 |
LY2835219 free base (Abemaciclib)
Featured
|
LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. |
|
| DC5062 |
LY2835219(Abemaciclib)
Featured
|
LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. |
|
| DC22595 |
LY2857785 |
LY2857785 is a potenrt, reversible and ATP-competitive CDK9 inhibitor with IC50 of 11 nM, also inhibits CDK8 (IC50=16 nM) and weakly inhibits CSK7 (IC50=246 nM). |
|
| DC7019 |
LY-2874455
Featured
|
LY2874455 is a novel and potent FGF/FGFR inhibitor. |
|
| DC5053 |
LY2886721
Featured
|
LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease. |
|
| DC11681 |
LY2922470 |
LY2922470 (LY-2922470) is a potent, selective, orally available GPR40 agonist with EC50 of 7 nM. |
|
| DC1058 |
LY294002
Featured
|
LY294002 is a PI3K inhibitor for p110α, p110δ and p110β with IC50 of 0.5 μM, 0.57 μM and 0.97 μM, respectively. |
|
| DC22312 |
LY2940094
Featured
|
LY2940094 is a potent and selective nociceptin receptor antagonist which inhibits excessive feeding behavior in rodents. |
|
| DC7191 |
LY-2940680(Taladegib)
Featured
|
LY2940680 binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling. |
|
| DC10833 |
LY2955303
Featured
|
LY2955303 is a potent and selective RAR-gamma antagonist for the treatment of osteoarthritis pain. |
|
| DC21340 |
LY 2979165 |
LY2979165 (MP-101) is the alanine prodrug of LY2812223, a selective orthosteric mGlu2 receptor agonist. |
|
| DC23688 |
LY-3000328
Featured
|
LY 3000328 is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, respectively. |
|
| DC8344 |
LY3009120
Featured
|
LY3009120 is a potent and selective pan-RAF inhibitor with potential anticancer activity. |
|
| DC10219 |
LY3023414
Featured
|
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK. |
|
