| DC8974 |
Mexiletine Hydrochloride
Featured
|
Mexiletine hydrochloride is a non-selective voltage-gated sodium channel blocker; Class IB anti-arrhythmic compound. |
|
| DC10917 |
MF-094
Featured
|
MF-094 (MF094) is a potent, highly selective inhibitor of ubiquitin specific protease 30 (USP30) with IC50 of 0.12 uM, demonstrates <30% inhibitory activity for a panel of 22 USPs assays at 10 uM. |
|
| DC23468 |
MF266-1 |
MF266-1 is a potent, selective prostaglandin E receptor subtype 1 (EP1) antagonist with Ki of 3.8 nM, displayes a relatively good selectivity over other prostanoid receptors.. |
|
| DC8249 |
MF498 |
MF498 is a novel and selective E prostanoid receptor 4 (EP4) inhibitor, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. |
|
| DC7651 |
MF63
Featured
|
MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively. |
|
| DC22145 |
MF-766
Featured
|
MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM); behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay; exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM); demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling. |
|
| DC23707 |
MFA-1 |
MFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays, displays 500-fold more potent than CDCA. |
|
| DC11211 |
MFN2 agonist B-A l |
MFN2 agonist B-A/l is a mall-molecule mimics of the peptide-peptide interface of MFN2, allosterically activates MFN2 and promotes mitochondrial fusion with EC50 of 3 nM. |
|
| DC7794 |
MG149
Featured
|
MG 149 is an inhibitor of histone acetyltransferases (HAT) with IC50 values of 74μM and 47μM for Tip60 and MOF, respectively. |
|
| DC7702 |
MG-101
Featured
|
MG-101 is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. |
|
| DC7816 |
MG-132
Featured
|
MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM. |
|
| DC7196 |
MGCD0103 (Mocetinostat)
Featured
|
MGCD0103 (Mocetinostat) is a potent HDAC inhibitor with IC50 of 0.15, 0.29 and 1.66 μM for HDAC 1, HDAC 2 and HDAC 3, respectively. |
|
| DC7462 |
MGCD-265 |
MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively; also inhibits Ron and Tie2. |
|
| DC9995 |
MGL-3196(Resmetirom)
Featured
|
MGL-3196 is a potent and highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia. |
|
| DC21918 |
MGR1 |
MGR1 is a ROS-generating probe that can generate ROS (reactive oxygen species) in different mammalian cells, causes concentration-dependent cell death in HEK293T with IC50 of 5.7 uM.. |
|
| DC22147 |
MGV354 R-form |
MGV354 is a novel potent, selective soluble Guanylate Cyclase (sGC) activator, lowers intraocular pressure (IOP) in preclinical models of glaucoma.. |
|
| DC22146 |
MGV354
Featured
|
MGV354 is a novel potent, selective soluble Guanylate Cyclase (sGC) activator, lowers intraocular pressure (IOP) in preclinical models of glaucoma.. |
|
| DC8074 |
MHY1485
Featured
|
MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes. |
|
| DC9503 |
MI 2 (MALT1 inhibitor)
Featured
|
MI 2(MALT1 inhibitor) is a small molecule and irreversible inhibitor of MALT1 with IC50 of 5.84 uM(suppression of proliferation in ABCDLBCL). |
|
| DC23290 |
MI 219 |
MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX. |
|
| DC8546 |
MI-136
Featured
|
MI-136 inhibits DHT-induced expression of androgen receptor (AR) target genes. |
|
| DC22148 |
MI-1481 |
MI-1481 (MI1481) is a highly potent inhibitor of the menin-MLL1 interaction with IC50 of 3.6 nM, 10-fold increase in inhibitory activity over MI-463 and MI-503. |
|
| DC7621 |
MI 2 (Menin-MLL Inhibitor)
Featured
|
MI-2 is an inhibitor of MALT1 with IC50 value of 5.84 μM. |
|
| DC20450 |
MI-2-2 hydrochloride |
MI-2-2 hydrochloride is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM). |
|
| DC20449 |
MI-2-2
Featured
|
MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM); inhibits the interaction of menin with MLL-AF9 in HEK293 cells in a dose-dependent manner with 4-fold potentcy improvement over MI-2; suppresses growth of MLL-AF9–transformed BMCs; causes MV4:11 cells growth inhibition of with GI50 of 3 uM. |
|
| DC23291 |
MI-223 |
MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents. |
|
| DC8246 |
MI-3 (Menin-MLL Inhibitor)
Featured
|
MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM. |
|
| DC8544 |
MI-463
Featured
|
MI-463 is a highly potent and orally bioavailable small molecule inhibitor of the menin-mLL interaction. |
|
| DC8545 |
MI-503
Featured
|
MI-503 is a highly potent and orally bioavailable small molecule inhibitor of the menin-MLL interaction. |
|
| DC10287 |
MI-538
Featured
|
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. |
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