| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC26095 | QX 314 chloride Featured | A membrane-impermeable sodium channel blocker, blocks sodium current in voltage-clamped nociceptive DRG neurons. |
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| DC22354 | O-Desmorpholinopropyl Gefitinib | A metabolite of Gefitinib, which is a potent inhibitor of tyrosine phosporylation in EGFR.. |
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| DC22914 | ST-4206 | A metabolite of ST1535, which is potent, selective A2A adenosine receptor antagonist with Ki of 6.6 nM.. |
|
| DC22824 | Endoxifen hydrochloride | A metabolite of tamoxifen, orally active non-steroidal selective estrogen receptor modulator (SERM) for the treatment of estrogen receptor-positive breast cancer.. |
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| DC23973 | F16 Featured | A mitochondriotoxic small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. |
|
| DC7289 | Imiloxan | A moderately potent, but highly selective α2-adrenoceptor antagonist, the only reported selective antagonist at the α2B-adrenoceptor not having potent α1-adrenoceptor antagonist activity. |
|
| DC23225 | Dronedarone | A multichannel blocker agent that has antiarrhythmic activity. |
|
| DC21008 | Fumonisin B1 | A mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS). |
|
| DC23641 | AMG 747 | A nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia. |
|
| DC11530 | Tapinarof (Benvitimod; GSK2894512) Featured | Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice. |
|
| DC11658 | Diptoindonesin G Featured | Dip G is a natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ. |
|
| DC24167 | Bergaptol | A natural furanocoumarin that is found to be a potent inhibitor of debenzylation activity of CYP3A4 enzyme with IC50 of 24.92 uM. |
|
| DC20476 | N-palmitoyl-l-leucine | A natural poduct that functions as a splicing inhibitor with IC50 of 35 uM, blocks a late stage of spliceosome assembly.. |
|
| DC22465 | Gedunin | A natural tetranortriterpenoid compound that inhibits Hsp90 and induce the degradation of Hsp90-dependent client proteins. |
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| DC11851 | Clitocine | A naturally occurring nucleoside analog that possesses antitumor activity, also is a potent and efficacious readthrough agent. |
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| DC25051 | Deoxygedunin | A naturally occurring tetranortriterpenoid that has been found to act as a potent, selective, small-molecule agonist of TrkB with Kd of 1.4 uM. |
|
| DC21030 | FzM1 | A negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism. |
|
| DC11790 | VU-WS211 | A negative control of VU-WS113, which is a potent inhibitor of Wnt signaling with EC50 of 80 nM that selectively potentiates CK1α kinase activity.. |
|
| DC25093 | Neuromedin N Featured | A neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.. |
|
| DC22366 | Bethoxazin | A new broad spectrum industrial microbicide with applications in material and coating preservation. . |
|
| DC7565 | BET bromodomain inhibitor,cas 1505453-59-7 | A new compound which is similar with +JQ-1，BET bromodomain inhibitor |
|
| DC11892 | Elsulfavirine Featured | A new-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV-1 infections, the prodrug of the active compound VM-1500A.. |
|
| DC23771 | HuR inhibitor 5 | A newly identified, small molecule HuR inhibitor that disrupts HuR multimerization modules and reduces tumor cell survival and proliferation.. |
|
| DC21556 | RA 839 | A noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling. |
|
| DC25046 | OSU-2S | A non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively. |
|
| DC23907 | Polyoxyethylene 40 stearate Featured | A non-ionic emulsifying agent that can modulate multidrug resistance and enhances antitumor activity of vinblastine sulfate by modulating substrate-stimulated P-gp ATPase activity. |
|
| DC22395 | NSAH | A nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM. |
|
| DCAPI1496 | Ambrisentan Featured | A nonpeptide endothelin ETA receptor antagonist. Antihypertensive. |
|
| DC22911 | AH-3960 Featured | A non-peptide small molecule agonist of the PTH1 receptor, activates both the cAMP and calcium signaling pathways.. |
|
| DC21236 | LLL-12 | A nonpeptide, cell-permeable STAT3 inhibitor that binds directly to the pTyr705 binding site of the STAT3 monomer. |
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