| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC22391 | Olorofim(F-901318) | Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp. |
|
| DC11998 | IND-114338 | A novel antiprion compound with EC50 of 68 nM, significantly increases monoglycosylated/diglycosylated PrPSc.. |
|
| DC11534 | Sudoterb Featured | A novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.. |
|
| DC11535 | Sudoterb dihydrchloride | A novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.. |
|
| DC11663 | GS-5759 | A novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM). |
|
| DC11997 | IND125 | A novel brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum. |
|
| DC11792 | UMB-136 | A novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation. |
|
| DC22507 | SCH-00013 | A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle, elicits positive inotropic effect in dog and rabbit ventricular muscles (EC50=9.2 uM). |
|
| DC11785 | IHR-1 | A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay. |
|
| DC11784 | IHR-Nac | A novel cell permeable smoothened antagonist with IC50 of 3.1 nM in Hh-dependent Gli transcriptional activity assay. |
|
| DC22789 | 5S rRNA modificator 2 | A novel chemical probe that enable selective 2’-hydroxyl acylation for accurate RNA structural analysis in living cells.. |
|
| DC11628 | HIV-1 Integrase Inhibitor 1 | A novel compound that disrupts the HIV-1 integrase LEDGF interaction. |
|
| DC11521 | Dotinurad Featured | Dotinurad is a novel compound that exhibits a remarkable uric acid excretion-promoting action. |
|
| DC20796 | BIOD303 | A novel conformational modulator of α-synuclein with EC50 of 105 uM, potentially outcompetes spermine in binding to α-synuclein. |
|
| DC8784 | CTLA-4 inhibitor Featured | A novel CTLA-4 inhibitor. |
|
| DC22975 | GB111-NH2 Featured | GB111-NH2 (Z-Phe-Lys-AOMK) is a novel cysteine cathepsin inhibitor that blocks the activity of cathepsins B, L and S. GB111-NH2 (Z-Phe-Lys-AOMK) inhibits autophagy and increases oxidative stress, specifically trigger macrophage cell death. |
|
| DC22648 | VMY-1-103 | A novel dansylated analog of purvalanol B, and a CDK inhibitor that inhibits cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B. |
|
| DC20927 | CRS-3123 | A novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases in Gram-positive bacteria as a novel agent to treat Clostridium difficile infection (CDI). |
|
| DC24099 | CC-115 hydrochloride | A novel dual inhibitor of mTOR and DNA-PK with IC50 of 21 nM and 13 nM, respectively. |
|
| DC21412 | SR-16157 | A novel dual-acting steroid sulfatase inhibitor (IC50=0.1 uM) and selective ERα modulator (SERM). |
|
| DC10706 | Ehp-inhibitor-2 Featured | A novel Ehp inhibitor |
|
| DC10705 | Ehp-inhibitor-1 Featured | A novel Ehp inhibitor |
|
| DC22487 | Benzenepentacarboxylic Acid Featured | Benzenepentacarboxylic acid is a fluorescent dye that detects and scavenge HO radicals. |
|
| DC22768 | MP07-66 Featured | A novel FTY720 analog that acts as PP2A activator, disrupts the SET/PP2A interaction devoid of immunosuppressive effects leads to the reactivation of PP2A. |
|
| DC23458 | AZD 9164 | A novel highly potent, selective, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, 10-fold selectivity over M2 (pIC50=9.0). |
|
| DC22883 | MK-7288 | A novel histamine H3 receptor inverse agonist for the treatment of sleep apnoea syndrome. |
|
| DC24012 | BI-224436 | A novel HIV-1 non-catalytic-site integrase inhibitor (NCINI). |
|
| DC22944 | NS-3623 Featured | A novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation). |
|
| DC23936 | IQ-R | A novel hypoxia-sensitive fluorescent probe. |
|
| DC22386 | I-2906 | A novel isocitrate lyase (ICL) inhibitor that displays showed excellent anti-Mycobacterium tuberculosisl activities and low cytotoxicity. |
|
