CNX-1351

  Cat. No.:  DC7104  
Chemical Structure
1276105-89-5
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More than 5000 active chemicals with high quality for research!
Field of application
CNX-1351 is a selective covalent Inhibitor of PI3Kα. CNX-1351 was tested against all four of the class I PI3K enzymes α, β, γ, and δ.
Cas No.: 1276105-89-5
Chemical Name: 1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione
Synonyms: CNX-1351; CNX 1351; CNX1351
SMILES: C/C(C)=C/C(CCC(N1CCN(CC2=CC3=NC(C4=CC=CC5=C4C=NN5)=NC(N6CCOCC6)=C3S2)CC1)=O)=O
Formula: C30H35N7O3S
M.Wt: 573.71
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: CNX-1351 is a selective covalent Inhibitor of PI3Kα. CNX-1351 was tested against all four of the class I PI3K enzymes α, β, γ, and δ. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20−400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.For the detailed information of CNX-1351, the solubility of CNX-1351 in water, the solubility of CNX-1351 in DMSO, the solubility of CNX-1351 in PBS buffer, the animal experiment (test) of CNX-1351, the cell expriment (test) of CNX-1351, the in vivo, in vitro and clinical trial test of CNX-1351, the EC50, IC50,and Affinity of CNX-1351, Please contact DC Chemicals.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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