Clitocine|

Cas No.:	105798-74-1
Chemical Name:	6-Amino-5-nitro-4-(ribofuranosylamino)pyrimidine
SMILES:	O[C@H]1[C@H](NC2=NC=NC(N)=C2[N+]([O-])=O)O[C@H](CO)[C@H]1O
Formula:	C₉H₁₃N₅O₆
M.Wt:	287.23
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A naturally occurring nucleoside analog that possesses antitumor activity, also is a potent and efficacious readthrough agent; weakly inhibits adenosine kinase (Ki=3 uM), and inhibits L1210 cells in vitro with LD50 of 30 nM; potently inhibits Mcl-1, effectively induces drug-resistant human cancer cell apoptosis in vitro and inhibits tumor xenograft growth in vivo; a potent and efficacious suppressor of nonsense mutations.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC46828	Fostroxacitabine bralpamide	Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide prodrug. Fostroxacitabine bralpamide has anticancer effects.
DC46678	5'-O-DMT-rU	5'-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.
DC45390	3'-Deoxyuridine-5'-triphosphate trisodium	3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM.
DC42293	Peldesine dihydrochloride	Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection treatment.
DC41423	Adenosine 5′-monophosphoramidate sodium	Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis. Adenosine 5′-monophosphoramidate has a significant effect on the accumulation of cyclic AMP.
DC40975	6-Azathymine	6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities.
DC40774	3'-Deoxyuridine-5'-triphosphate	3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM.
DC40314	Adenosine dialdehyde	Adenosine Dialdehyde, a purine nucleoside analogue, is an irreversible inhibitor of S-adenosylhomocysteine hydrolase (SAH) (IC50=40 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research.
DC28960	(Rac)-Plevitrexed	(Rac)-Plevitrexed ((Rac)-ZD 9331; (Rac)-BGC9331) is a racemate of Plevitrexed. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor.
DC28958	Plevitrexed	Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical.