A-412997|A 412997;A412997

Cas No.:	1347744-96-0
Chemical Name:	N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide
Synonyms:	A 412997;A412997
SMILES:	N(CC(NC1=CC=CC(C)=C1)=O)1CCC(C2=NC=CC=C2)CC1
Formula:	C₁₉H₂₅Cl₂N₃O
M.Wt:	382.327302694321
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective dopamine D4 receptor agonist with Ki of 12.1 and 7.9 nM for rat and human D4 receptors, respectively; displays excellent selectivity profile for other dopamine receptors or a panel of 70 different receptors and channels (Ki>1 uM); fully activates rat D4 receptor at 28.4 nM, does not activate rat dopamine D2L; induces penile erection in a conscious rat model with comparable efficacy as the nonselective D2-like agonist, apomorphine; also improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rats.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47684	Dopamine D3 receptor antagonist-1	Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor-selective or multitarget bitopic ligand (Ki = 1.58 nM) potentially useful for central nervous system disorders.
DC47682	Dopamine D3 receptor antagonist-2	Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor-selective (Ki = 2.16 nM) or multitarget bitopic ligand potentially useful for central nervous system disorders.
DC47266	SKF83822 hydrobromide	SKF83822 hydrobromide is a potent dopamine D1 receptor agonist. SKF83822 hydrobromide activates Gs/olf/adenylyl cyclase (AC)-coupled D1 receptors, but not phospholipase C (PLC)-coupled D1-like receptors.
DC47254	BP 897	BP 897 is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM). BP 897 exhibits selective inhibition of cocaine-seeking behavior.
DC47173	Roxindole	Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities.
DC47110	Deudomperidone	Domperidone-d4 is a deuterium labeled Domperidone (R33812).Domperidone is a selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine.
DC47054	Trazpiroben	Trazpiroben (TAK-906) is a dopamine D2/D3 receptor antagonist used for chronic research of moderate-to-severe gastroparesis.
DC47044	Onzigolide	Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors.
DC47014	Medifoxamine	Medifoxamine is a monoamine re-uptake inhibiting antidepressive drug which preferentially inhibits dopamine reuptake.
DC46841	Quinelorane dihydrochloride	Quinelorane dihydrochloride (LY163502) is a potent dopamine D3/D2 receptor agonist. Quinelorane has the potential for neurological and psychiatric disorders research.