SBI-425 |CAS 1451272-71-1|DC Chemicals

Cas No.:	1451272-71-1
Chemical Name:	3-Pyridinecarboxamide, 5-[[(5-chloro-2-methoxyphenyl)sulfonyl]amino]-
Synonyms:	3-Pyridinecarboxamide, 5-[[(5-chloro-2-methoxyphenyl)sulfonyl]amino]-;5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide;SBI-425
SMILES:	ClC1C=CC(=C(C=1)S(NC1C=NC=C(C(N)=O)C=1)(=O)=O)OC
Formula:	C₁₃H₁₂ClN₃O₄S
M.Wt:	341.770080566406
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SBI-425 (SBI425) is a potent, selective, orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 16 nM, shows high selectivity over other alkaline phosphatases including IAP and PLAP; demonstrates activity in blocking calcification in patient derived fibroblasts as well as in rodent models of GACI and PXE, reduces coronary calcium and lipids, improves body weight and ejection fraction in WHC-eTNAP mice.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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