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DPH

  Cat. No.:  DC22378   Featured
Chemical Structure
484049-04-9
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More than 5000 active chemicals with high quality for research!
Field of application
A cell-permeable, small-molecule c-Abl kinase activator with pEC50 of 6.1(EC50=794 nM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 484049-04-9
Chemical Name: 5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione
Synonyms: 5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione;DPH;5-[3-(4-fluorophenyl)-1-phenylpyrazol-4-yl]imidazolidine-2,4-dione;5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione;5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]imidazolidine-2,4-dione;HMS2301N21;5-(1,3-diaryl-1H-pyrazol-4-yl)hydantoin
SMILES: O=C1NC(C(N1)C2=CN(N=C2C3=CC=C(C=C3)F)C4=CC=CC=C4)=O
Formula: C18H13N4O2F
M.Wt: 336.31982
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A cell-permeable, small-molecule c-Abl kinase activator with pEC50 of 6.1(EC50=794 nM); binds to the myristoyl binding site, also stimulates in vitro c-Abl phosphorylation; induces both pY245 (pEC50=5.6) and pY412 c-Abl phosphorylation; dose dependently induces Crk-L pY207 in KG-1 cells; the first small-molecule tool compound for c-Abl activation.
In Vitro: DPH binds to the myristoyl binding site and prevents the formation of the bent conformation of the αI helix through steric hindrance, a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site. DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation[1].
References: [1]. Yang J, et al. Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site. Chem Biol. 2011 Feb 25;18(2):177-86 [2]. Shapiro LP, et al. Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase. Mol Cell Neurosci. 2017 Oct 26;85:226-234.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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