PQ-10| CAS 927691-21-2|DC Chemicals

Cas No.:	927691-21-2
Chemical Name:	6,7-Dimethoxy-4-[(3r)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]quinazoline
Synonyms:	6,7-Dimethoxy-4-[(3r)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]quinazoline;6,7-dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline;6,7-Dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]-quinazoline;PQ 10
SMILES:	COC1=C(C=C2C(=C1)C(=NC=N2)N3CC[C@H](C3)OC4=NC5=CC=CC=C5N=C4)OC
Formula:	C₂₂H₂₁N₅O₃
M.Wt:	403.434
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM; displays 53-fold and 68-fold selectivity over PDE3A and PDE3B, respectively; selectively inhibits colon tumor cell growth with IC50 of 0.1-28 uM; selectively activates cGMP/cGMP-dependent protein kinase signaling to suppress β-catenin levels and T-cell factor (TCF) transcriptional activity in colon tumor cells.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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