CCT129202| CAS 942947-93-5|DC Chemicals

Cas No.:	942947-93-5
Chemical Name:	CCT129202
Synonyms:	CCT129202;2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-1H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide;2-[4-[6-chloro-2-[4-(dimethylamino)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide;CCT-129202;2-[4-[6-Chloro-2-(4-dimethylaminophenyl)-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(thiazol-2-yl)acetamide;4-[6-Chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl-1-piperazineacetamide (ACI);CCT 129202;2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]-pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide;SCHEMBL209571;2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-1H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide;CCG-269670;SMR004702831;MLS006011038;AKOS030230261;2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide;BRD-K57136142-001-02-4;2-(4-(6-Chloro-2-(4-dimethylaminophenyl)-3H-imidazo(4,5-b)pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide;MS-29227;CS-0206;J-505098;DTXCID10163897;Q27270773;SW219480-1;2-(4-{6-CHLORO-2-[4-(DIMETHYLAMINO)PHENYL]-1H-IMIDAZO[4,5-B]PYRIDIN-7-YL}PIPERAZIN-1-YL)-N-(1,3-THIAZOL-2-YL)ACETAMIDE;2-{4-[6-Chloro-2-(4-dimethylamino-phenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-piperazin-1-yl}-N-thiazol-2-yl-acetamide;NCGC00346539-05;BCPP000297;QYKHWEFPFAGNEV-UHFFFAOYSA-N;UNII-8N349V9Q27;1-piperazineacetamide, 4-[6-chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl-;HMS3654B20;942947-93-5;BRD-K57136142-001-03-2;BCP02164;BCP9000497;DTXSID50241406;NCGC00346539-01;CHEMBL392525;SB19307;s1519;BDBM50224734;HY-12049;1-Piperazineacetamide, 4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo(4,5-b)pyridin-7-yl)-N-2-thiazolyl-;SDCCGSBI-0654376.P001;F83008;8N349V9Q27;GLXC-02938
SMILES:	O=C(CN1CCN(C2C3=C(N=C(C4C=CC(N(C)C)=CC=4)N3)N=CC=2Cl)CC1)NC1SC=CN=1
Formula:	C₂₃H₂₅ClN₈Os
M.Wt:	497.015600919724
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CCT129202 is a potent, selective, ATP-competitive pan-Aurora kinase inhibitor with IC50 of 42, 198 and 227 nM for Aurora A, Aurora B and Aurora C, respectively; displays high selectivity for the Aurora kinases over a broad range of 13 other kinases; inhibits proliferation in multiple cultured human tumor cell lines (GI50=0.08-1.7 uM), induces aberrant mitosis that leads to apoptosis; reduces phosphorylation of histone H3, stabilizes p53, and inhibits growth of HCT116 human colon cancer xenografts in athymic mice.

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2018-0101

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