6-Ethylthioinosine

  Cat. No.:  DC23336  
Chemical Structure
13286-04-9
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More than 5000 active chemicals with high quality for research!
Field of application
6-Ethylthioinosine (6-ETI.
Cas No.: 13286-04-9
Chemical Name: (2R,3R,4R,5R)-2-(6-ethylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Synonyms: 6-ETI;NSC 39368;SRI 1215
Formula: C12H16N4O4S
M.Wt: 312.344
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: 6-Ethylthioinosine (6-ETI;NSC 39368;SRI 1215) is a nucleoside analog that effectively and selectively inhibits Primary effusion lymphoma (PEL) in vitro and in vivo, but not to other lymphoma cell lines; has LC50 of 30-435 nM against KSHV+ PEL cell lines, and inhibits NF-κB in PELs at 10-50 uM; requires adenosine kinase (ADK) to phosphorylate and activate 6-ETI; induces ATP depletion and cell death accompanied by S phase arrest and DNA damage only in ADK-expressing cells; shows a robust antitumor effect in a disseminated MM mouse model.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC47243 Dehydroglyasperin C Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.
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DC47224 GPX4-IN-3 GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM.
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DC47140 Yadanzioside K Yadanzioside K is a natural quassinoid glucoside found in Brucea amarissima.
DC47105 Complanatoside B Complanatoside B is a P. chinense Fisch flavonoid with potential anti-inflammatory effects.
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