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PF-06650833

  Cat. No.:  DC24082   Featured
Chemical Structure
1817626-54-2
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More than 5000 active chemicals with high quality for research!
Field of application
PF06650833 is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. PF06650833 is used to treat diseases such as rheumatoid arthritis, l
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1817626-54-2
Chemical Name: 6-Isoquinolinecarboxamide, 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-
Synonyms: PF06650833;PF 06650833
SMILES: NC(=O)C1C=C2C=CN=C(OCC3NC(=O)C(F)C3CC)C2=CC=1OC
Formula: C18H20FN3O4
M.Wt: 361.3675
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Lee KL, et al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fr
Description: PF06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), and used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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