Donepezil|cas 120014-06-4|DC Chemicals

Cas No.:	120014-06-4
SMILES:	C(N1CCC(CC2CC3C(=CC(OC)=C(OC)C=3)C2=O)CC1)C1C=CC=CC=1
Formula:	C₂₄H₂₉NO₃
M.Wt:	379.49
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. Donepezil inhibits the carbachol-stimulated increase in intracellular Ca2+ concentration in human SHSY5Y neuroblastoma cells in a concentration dependent manner, indicating that Donepezil have muscarinic antagonist activity. Intraperitoneal administration of Donepezil in rats produces a dose dependent increase in salivation and tremor, which are overt cholinergic behavioural signs, with an ED50 of 6 μmol/kg. Donepezil is found to be somewhat less potent with a ED50 of 50 μmol/kg following oral administration. A recent study shows that Donepezil can protect human umbilical vein endothelial cells (HUVECs) against H2O2-induced cell injury. This may be useful as a potential therapy for oxidative stress in cardiovascular and cerebrovascular diseases.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
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DCAPI1543	Neostigmine Methylsulfate	Neostigmine Methyl Sulfate is a reversible acetylcholinesterase inhibitor. This compound blocks the breakdown of acetylcholine in the synaptic space, leading to prolonged signaling and thus increased muscle contractions.
DC9046	Neostigmine bromide	Neostigmine Bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis.
DCAPI1460	Naratriptan hydrochloride	Naratriptan Hydrochloride is a triptan drug which is used for the treatment of migraine headaches.
DC9090	Galanthamine hydrobromide	Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors.
DC9102	Donepezil	Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.