Tazarotenic acid (AGN 190299)|cas 118292-41-4|From Supplier DC Chemicals

Cas No.:	118292-41-4
Chemical Name:	6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylic acid
Synonyms:	Tazarotenic acid, 118292-41-4, 6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinic acid
SMILES:	O=C(O)C1=CN=C(C#CC2=CC=C3C(C(C)(C)CCS3)=C2)C=C1
Formula:	C₁₉H₁₇NO₂S
M.Wt:	323.40878
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma[1][2][3].

In Vivo:

Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats[1] . Male Female Male Dose (mg kg-1) 4.4 4.4 0.49 AUC (μg h mL-1) 9.31 (2.14) 9.78 (1.36) 0.594 (0.95) CL (mL min-1 kg-1) 7.96 (1.59) 7.62 (0.85) 14.0 (2.2) k (h-1) 0.562 (0.339) 0.820 (0.146) 0.741 (0.115) T1/2 (h) 1.64 (0.92) 0.86 (0.14) 0.95 (0.16) V0 (L kg-1) 0.43 (0.05) 0.49 (0.06) 1.31 (1.15) Vβ (L kg-1) - - 1.14 (0.09) Vmax (μg min-1) 9.08 (2.89) 6.09 (1.22) - Km (μg mL-1) 7.09 (1.35) 5.12 (1.19) -

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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