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RO-275

Cat. No.: DC73620

Chemical Structure

2648837-04-9

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Field of application

RO-275 is a potent, selective HCN1 ion channel inhibitor with IC50 of 46 nM, displays 311/100/302-fold selectivity over HCN2/HCN3/HCN4.

Chemicals Properties Biological activity COA & MSDS Related products Datasheet

Cas No.:	2648837-04-9
Chemical Name:	RO-275
Formula:	C₁₈H₁₄ClN₅O
M.Wt:	351.79

MSDS

Cat. No.	Product name	Field of application
DC73619	Org 34167	Org 34167 HCl salt is a broad-spectrum inhibitor of HCN channels with IC50 of 23.4, 8.2 and 9.2 uM for HCN1, HCN2 and HCN4 channels, respectively, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation.
DC73620	RO-275	RO-275 is a potent, selective HCN1 ion channel inhibitor with IC50 of 46 nM, displays 311/100/302-fold selectivity over HCN2/HCN3/HCN4.
DC73618	NUCC-0200590	NUCC-0200590 is a small-molecule inhibitor of the TRIP8b-HCN interaction with IC50 of 7.0 uM in AlphaScreen assays, effectively disrupts the TRIP8b-HCN interaction in vitro and in vivo.
DC70477	HCN4 inhibitor EC18	HCN4 inhibitor EC18 (EC18) is a HCN4-prefering blocker.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.