Cat. No. | Product name | CAS No. |
DC10437 |
MRE-269
Featured
MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist. |
475085-57-5 |
DC11047 |
MRL871
Featured
MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM; significantly reduces the IL17a mRNA levels in EL4 murine lymphoblast cell line at 10 uM. |
1392809-08-3 |
DC20220 |
MRS-1845
Featured
MRS 1845 is a potent calcium channel protein inhibitor and inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM). |
544478-19-5 |
DC12251 |
MRS-1706
Featured
MRS-1706 is a potent and selective adenosine A2B receptor antagonist with Ki of 1.39 nM. |
264622-53-9 |
DC12803 |
MRS1754
Featured
MRS1754 is a selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively). |
264622-58-4 |
DC7203 |
MRS 2578
Featured
MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. |
711019-86-2 |
DC10635 |
MRT67307 HCl
Featured
MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. |
1190378-57-4 |
DC12651 |
MRTX1257
Featured
MRTX1257 (MRTX-1257, MRTX 1257) is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 0.9 nM. |
2206736-04-9 |
DC9293 |
MS023
Featured
MS023 is a potent, selective, and cell-active inhibitor of human type I PRMTs with IC50 of 4-119 nM. |
1831110-54-3 |
DC8805 |
MS049 (hydrochloride)
Featured
MS049 is a potent and selective inhibitor of PRMT4 and PRMT6 that is active in cells. |
2095432-59-8 |
DC21348 |
MS2734
Featured
MS2734 is a bisubstrate Nicotinamide N-methyltransferase (NNMT) with IC50 of 14 uM, Kd of 2.7 uM.. |
|
DC8574 |
MS37452
Featured
MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM). |
423748-02-1 |
DC22871 |
MS-402
Featured
MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice. |
1672684-68-2 |
DC21351 |
MS4078
Featured
MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM). |
2229036-62-6 |
DC7682 |
MS417
Featured
MS417 is a novel BrD inhibitor with high affinity and specificity For the BrDs of BET proteins. pIC50 7.52 (IC50 30 nM). |
916489-36-6 |
DC7620 |
MS436
Featured
MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM. |
1395084-25-9 |
DC20466 |
MsbA inhibitor 1
Featured
MsbA inhibitor 1 is a novel small molecule lipopolysaccharide biogenesis inhibitor, inhibits MsbA, an ATP-dependent flippase that translocates LPS across the inner membrane; causes mislocalization of LPS to the cell interior, inhibits Δ5 strain with MIC o |
52535-76-9 |
DC22166 |
MSC2504877
Featured
MSC2504877 (MSC-2504877) a novel small molecule selective tankyrase inhibitor with IC50 of 0.7/0.8 nM against TNKS1/2, shows 771-fold selectivity for TNKS1 over PARP1 (IC50=0.54 uM). |
1460286-21-8 |
DC10627 |
MSC2530818
Featured
MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable. |
1883423-59-3 |
DC10894 |
MSDC-0602
Featured
MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes. |
1133819-87-0 |
DC11310 |
MST312
Featured
MST312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay). |
368449-04-1 |
DC8822 |
MSX-122
Featured
MSX-122 is a n orally bioavailable inhibitor of CXCR4 with potential antineoplastic and antiviral activities. |
897657-95-3 |