| DC60216 |
SB-747651A dihydrochloride
Featured
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SB-747651A dihydrochloride is a potent MSK1 inhibitor; also inhibiting other AGC group kinases. |
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| DC60217 |
NBI-31772
Featured
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NBI 31772 is a nonpeptide ligand that releases insulin-like growth factor-1 (IGF-1) from its binding protein (IGFBP; Kis = 1-24 nM for the six human subtypes of IGFBP).1,2 As the released IGF-1 is biologically active, NBI 31772 is used to assess the role of IGF-1 in cells and animals, including in neuron survival, skeletal muscle regeneration, and glucose homeostasis.3,4,5 |
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| DC60218 |
Azidamfenicol
Featured
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Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic that is active against Gram-negative and Gram-positive bacteria.1 It inhibits ribosomal peptidyltransferase (Ki = 22 µM).2 |
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| DC60219 |
Camibirstat (FHD-286)
Featured
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FHD-286 is a selective, oral inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor. FHD-286 has the potential for the research of BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia. |
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| DC60220 |
GLUT inhibitor-1
Featured
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| DC60221 |
MKC-1
Featured
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MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. |
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| DC60222 |
RP 70676
Featured
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RP 70676 is a potent and orally bioavailable inhibitor of ACAT. |
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| DC60223 |
Viridicatol
Featured
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Viridicatol is a fungal metabolite that has been found in various Penicillium species as well as Phoma with antimicrobial properties. |
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| DC60224 |
WAY-270599
Featured
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| DC60225 |
AOD-9604
Featured
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AOD-9604 is a potential anti-obesity peptide based on human growth hormone. AOD9604 was originally developed after research on mice, but subsequent studies in human have shown no efficacy for the potential treatment of obesity. |
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| DC60226 |
Beclamide
Featured
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Beclamide is a drug that possesses anticonvulsant activity. It is no longer used. Beclamide is possibly metabolized to 3-chloropropanoic acid in vivo, which binds to the GHB receptor. It has been used as a sedative and as an anticonvulsant. It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalised tonic-clonic seizures. It was not effective for absence seizures. Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment of schizophrenia. While not classified as a DEA controlled substance in the United States, this product can only be sold STRICTLY to universities and research institutions. This product will not be sold to individuals or shipped to residential addresses. |
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| DC60227 |
Cadralazine
Featured
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Cadralazine is a peripheral arteriolar vasodilator and an antihypertensive drug. |
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| DC60228 |
KCNQ1 activator-1
Featured
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| DC60229 |
VU0360172
Featured
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VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). VU0360172 is selective for mGlu5 and it displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors. |
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| DC60230 |
RUVBL1/2 ATPase-IN-1
Featured
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RUVBL1/2 ATPase-IN-1 (compound 18) is a potent and selective inhibitor of RUVBL1/2 ATPase with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1 and RUVBL2 are highly conserved AAA ATPases (ATPases Associated with various cellular Activities) and highly relevant to the progression of cancer. RUVBL1/2 ATPase-IN-1 has the potential for the research of cancer diseases. |
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| DC60232 |
CL-418030
Featured
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| DC60233 |
WYE-176092
Featured
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| DC60234 |
PF-06821497
Featured
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PF-06821497 (compound 23a) is a potent, selective and orally active Enhancer of Zeste Homolog 2 (EZH2) inhibitor, with a Ki value <0.1 nM against mutant Y641N EZH2. Exhibits robust tumor growth inhibition. |
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| DC60235 |
Hydrazinium hydroxide
Featured
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| DC60236 |
Imiquimod hydrochloride
Featured
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Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod hydrochloride exhibits antiviral and antitumor effects in vivo. Imiquimod hydrochloride can be used for the research of external genital, perianal warts, cancer and COVID-19. |
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| DC60237 |
7-Chlorokynurenic acid sodium salt
Featured
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| DC60238 |
AM103
Featured
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AM 103 is a potent and selective FLAP inhibitor, with an IC50 value of 4.2 nM. |
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| DC60239 |
Uridine 5′-diphosphoglucose
Featured
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| DC60240 |
(S)-PF-06873600
Featured
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| DC60241 |
FluvoxaMine
Featured
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| DC71588 |
SRI-37330 hydrochloride
Featured
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SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research. |
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| DC71590 |
(Rac)-CFT7455
Featured
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(Rac)-CFT7455 is a zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) degrader, acting via the ubiquitin proteasome pathway, with a GI50 of 0.05 nM for NCIH929.1 cells. (Rac)-CFT7455 is the racemic isomer of CFT7455 which is a IKZF1/IKZF3 degrader with anticancer activity. |
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| DC71605 |
GSK-1520489A
Featured
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GSK-1520489A(EX-A5430) is an active Protein Kinase, Membrane Associated Tyrosine/Threonine 1 (PKMYT1) inhibitor. |
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| DC71606 |
(Rac)-IBT6A
Featured
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IBT6A (BTK inhibitor 1) is an impurity of Ibrutinib, which is a Btk inhibitor (IC50=0.5 nM), and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. |
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| DC71608 |
Euquinine
Featured
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Euquinine is generally used as a febrifuge, antimalarial, and tonic. |
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