| DC60618 |
dWIZ-2
Featured
|
dWIZ-2 is a molecular glue degrader of the WIZ transcription factor that robustly induce HbF in erythroblasts. dWIZ-2 shows improved pharmacokinetic (PK) properties than dWIZ-1. |
|
| DC60620 |
REM0046127 (REM127)
Featured
|
REM0046127 (REM127) is a ReS19-T compound and restores calcium homeostasis and neutralizes tau- and Aβ-driven neurotoxicity. REM127 reduces toxicity and [Ca2+]cyto with EC50 of 15 and 19 nM, respectively but has no effect on tau expression or ATRA-dependent gene transcription. |
|
| DC60621 |
MK-1084
Featured
|
MK-1084 is an orally bioavailable and low-dose KRAS/G12C covalent inhibitor with IC50 of 1.2 nM (GNE) and 9 nM (p-ERK), respectively. |
|
| DC60622 |
KM822
Featured
|
KM822 is avselective, noncompetitive modulator of human dopamine transporter (DAT) with IC50 3.7 μM, which shows 30 and 50 folds higher than for human norepinephrine transporter (hNET) and human serotonin transporter (SERT), respectively. |
|
| DC60623 |
CNDR-51997
Featured
|
CNDR-51997 is a brain-penetrant microtubule alterations-stabilizing small molecule and reduces both Aβ plaque and tau inclusion pathology in established mouse models of Alzheimer's disease. |
|
| DC60624 |
OPB-171775
Featured
|
OPB-171775 is a non-TKI compound that exhibits significant anticancer activity against gastrointestinal stromal tumor (GIST) regardless of KIT mutation status. OPB-171775 induces targeted cell death by inducing a complex between phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12). |
|
| DC66576 |
Peracetylated GalNAc-L96-Acid-1
Featured
|
|
|
| DC66577 |
Propargyl PEG Linker Phosphoramidite
Featured
|
|
|
| DC66578 |
Cluster
Featured
|
|
|
| DC66581 |
C3-Phosphoramidites
Featured
|
|
|
| DC60625 |
NF764
Featured
|
NF764 is an analogue of EN83 (CTNNB1 degrader) with improved potency with DC50 of 3.5 nM. NF764 only adducts C619 and shows much more selective than EN83 with 61 significant off-targets. |
|
| DC60626 |
EN83
Featured
|
EN83 is a monovalent degrader of CTNNB1 that directly and covalently targets CTNNB1 three cysteines C466, C520, and C619, leading to destabilization and degradation of CTNNB1. |
|
| DC60630 |
Bivamelagon (Synonyms: MC-4R Agonist 2)
Featured
|
Bivamelagon is a melanocortin receptor agonist. |
|
| DC66585 |
Turbinaric acid
Featured
|
Turbinaric acid is a moderately cytotoxic secosqualene carboxylic acid that is isolated from the brown alga Turbinaria ornata. |
|
| DC66586 |
IDH1 Inhibitor 8
Featured
|
IDH1 Inhibitor 8 (91) is isocitrate dehydrogenase 1 (IDH1) inhibitor. IDH1 Inhibitor 8 can be used for the research of cancer. |
|
| DC60631 |
T-10418
Featured
|
T-10418 is a potent and selective G2A agonist with EC50 of 0.82 μM. T-10418 exhibits higher potency than the reference and natural ligand 9-HODE and high selectivity among G protein-coupled receptors. T-10418 is a suitable candidate for in vivo studies on therapeutic potential of G2A agonism. |
|
| DC60633 |
AZ9567
Featured
|
AZ'9567 is a potent inhibitor of MAT2A with pIC50 of 8.2. in vitro with excellent preclinical pharmacokinetic properties. AZ'9567 shows robust antitumor response in the MTAP KO HCT116 model. |
|
| DC60634 |
LL-K12-18
Featured
|
LL-K12-18 is a dual-site molecular glue for CDK12-DDB1 complex with EC50 of 0.37 nM. LL-K12-18 shows an 80-fold enhanced potency than SR-4835 in MDA-MB-231 cells and with a 307-fold boost potency (EC50 = 0.03 nM) in MDA-MB-468 cells, while the degradation efficiency (DC50 = 0.38 nM) increased 50-fold. |
|
| DC60635 |
DS18
Featured
|
DS18 is a DDB1-CDK12 molecular glue with EC50 of 8.771 nM. |
|
| DC66588 |
GlyRS-IN-1
Featured
|
GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor extracted from patent WO 2017066459 A1. GlyRS-IN-1 can also inhibit the growth of bacteria. |
|
| DC66589 |
1,4,7,10-Tetraoxa-13,16-diazacyclooctadecane
Featured
|
|
|
| DC66590 |
3-Pyrrolidinol, 5-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-, hydrochloride (1:1), (3S,5R)-
Featured
|
|
|
| DC66591 |
5-bromo-1H-pyrrolo[2,3-b]pyridine-2,3-dione
Featured
|
|
|
| DC66592 |
GW274150 dihydrochloride
Featured
|
GW274150 (dihydrochloride) is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 (dihydrochloride) displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 (dihydrochloride) exerts a protective role in an acute model of lung injury inflammation. |
|
| DC66593 |
HP-NH2
Featured
|
|
|
| DC66594 |
AJ-76
Featured
|
AJ-76 ((+)-AJ 76; (1S,2R)-AJ 76) is a dopamine autoreceptor antagonist. AJ-76 can increase the synthesis and turnover of dopamine in the rat brain, while having little effect on the synthesis and turnover of serotonin (5-HT) and norepinephrine. AJ-76 can also antagonize the sedative effects of low-dose apomorphine and has a weak antagonistic effect on postsynaptic dopamine receptor. |
|
| DC66595 |
(+)-UH 232
Featured
|
(+)-UH 232 is a partially selective agonist of the D3 receptor with an intrinsic activity of 0.2-0.4. (+)-UH 232 antagonized quinpirole-induced mitogenesis with a Ki value of 9.4 nM. |
|
| DC66596 |
Bartsiosid
Featured
|
Bartsioside is an anti-inflammatory agent which can be extracted from C. deserticola. Bartsioside exerts no significant cytotoxicity under 40 μM to BV-2 cells. |
|
| DC66597 |
1-O-palmityl-D-glucuronic acid
Featured
|
|
|
| DC66598 |
Octadecyl β-D-glucopyranosiduronic acid
Featured
|
|
|
