7ACC2|cas 1472624-85-3|DC Chemicals

Cas No.:	1472624-85-3
Chemical Name:	7-(Benzyl(methyl)amino)-2-oxo-2H-chromene-3-carboxylic acid
Synonyms:	7ACC-2;7ACC2;compound 19 [PMID: 24095010];7-ACC2;7-(Benzyl(methyl)amino)-2-oxo-2H-chromene-3-carboxylic acid;7-[benzyl(methyl)amino]-2-oxochromene-3-carboxylic acid;7ACC 2;GTPL8818;XTKDQPFUOFAMRL-UHFFFAOYSA-N;BCP11646;BDBM50442711;s6732;AK547419;Q27076338;2-Oxo-7-(methylbenzylamino)-2H-1-benzopyran-3-carboxylic acid;7-[methyl(phenylmethyl)amino]-2-oxo-2H-1-benzopyran-3-carboxylic acid
SMILES:	O1C(C(C(=O)O[H])=C([H])C2C([H])=C([H])C(=C([H])C1=2)N(C([H])([H])[H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O
Formula:	C₁₈H₁₅NO₄
M.Wt:	309.316
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT inhibitor; lactate transport inhibitor7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC72788	AZD0095	AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib.
DC11218	BAY-8002	BAY-8002 is a novel potent, selective, orally available monocarboxylate transporter 1 (MCT1) inhibitor (Kd=7.9 nM).
DC9263	AZD-3965	AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 μM.
DC7876	7ACC2	7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.