Cat. No. | Product name | CAS No. |
DC10425 |
AZD9056 hydrochloride
AZD9056 is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases. |
345303-91-5 |
DC9596 |
Azimilide (Dihydrochloride)
Azimilide 2Hcl(NE-10064 2Hcl) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. |
149888-94-8 |
DC10992 |
Azosemide
Azosemide (Azosemidum) is a potent Na-K-Cl Cotransporter NKCC1 with IC50 of 0.246 and 0.197 uM for hNKCC1A and NKCC1B, being about 4-times more potent than bumetanide. |
27589-33-9 |
DC12033 |
(S)-B-973B
Featured
B-973 (B973) is a potent, selective α7 nAChR ago-PAM, denonstrates analgesic effect with attenuating pain behavior and decreasing paw edema in vivo. |
2244989-34-0 |
DC8971 |
Baclofen
Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. |
1134-47-0 |
DC9869 |
Bamaquimast
Bamaquimast is an inhibitor of proton pump extracted from patent US2005165041, example 138. |
135779-82-7 |
DC9935 |
Basmisanil(RG1662)
Featured
Basmisanil is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors which is under development by Roche for the treatment of cognitive impairment associated with Down syndrome. |
1159600-41-5 |
DC11218 |
BAY-8002
Featured
BAY-8002 is a novel potent, selective, orally available monocarboxylate transporter 1 (MCT1) inhibitor (Kd=7.9 nM). |
724440-27-1 |
DC10107 |
BAY-876
Featured
BAY-876 is the first highly selective GLUT1 inhibitor with IC50 of 0.002 uM. show good metabolic stability in vitro and high oral bioavailability in vivo. |
1799753-84-6 |
DC9826 |
BCTC
Featured
BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
393514-24-4 |
DC8186 |
Bexagliflozin3
Featured
Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively. |
1118567-05-7 |
DC8882 |
Bitopertin
Bitopertin, also known as RG1678, is a potent and selective inhibitor of GlyT1 with an EC50 of 30nM. |
845614-11-1 |
DC8457 |
BMS-309403
Featured
BMS309403 is orally active, reducing atherosclerosis in mice lacking apoplipoprotein E. |
300657-03-8 |
DC10387 |
BPO-27 racemat
BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. |
1314873-02-3 |
DC10605 |
Brevianamide F
Featured
Brevianamide F , also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. |
38136-70-8 |
DCAPI1140 |
Bumetanide
Featured
Bumetanide |
28395-03-1 |
DC3111 |
Canagliflozin
Featured
Canagliflozin is a highly potent and selective SGLT2 inhibitor for CHO-hSGLT2, CHO-rSGLT2 and CHO-mSGLT2 with IC50 of 4.4 nM, 3.7 nM and 2 nM, respectively. |
842133-18-0 |
DC9193 |
Carbamazepine
Featured
Carbamazepine, a sodium channel blocker, is an anticonvulsant drug. |
298-46-4 |
DC7990 |
Cariporide
Cariporide is a selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). |
159138-80-4 |
DC10948 |
CDN1163
Featured
CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes; increases Ca2+-ATPase activity and significantly enhances Ca2+ uptake into the ER, attenuates H2O2-stimulated cell death in HEK cells; improves glucose homeostasis and metabolic parameters, increases glucose tolerance in ob/ob mice; CDN1163 reduces lipid accumulation and decreases lipogenesis in obese mice livers. |
892711-75-0 |
DC9340 |
CFM-2
CFM-2 is a selective non-competitive AMPAR antagonist. |
178616-26-7 |
DC7039 |
CFTR Inhibitor II
Featured
CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells. |
328541-79-3 |