Cat. No. | Product name | CAS No. |
DC11944 |
VU714
A potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays. |
441289-66-3 |
DC11753 |
BL-1249
Featured
BL-1249 is a nonsteroidal anti-inflammatory drug (NSAID) and a potassium channel activator. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM). BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively |
18200-13-0 |
DC11943 |
MRT2000769
A potent Kir7.1 inhibitor with IC50 of 2.0 uM, induces long-lasting uterine contractility similar to those observed with VU590.. |
1214573-32-6 |
DC11839 |
Org 25543
A potent, highly selective glycine transporter 1 (GlyT2) inhibitor with IC50 of 16 nM with negligible affinity for GlyT1.. |
495076-64-7 |
DC11675 |
Synta-66
A potent, selective CRAC channel Orai1 blocker with IC50 of 3 uM. |
835904-51-3 |
DC11838 |
Org 25935
A potent, selective glycine transporter 1 (GlyT1) inhibitor with IC50 of 100 nM. |
949588-40-3 |
DC11967 |
PF-06649298
A potent, selective inhibitor of the Na+/citrate transporter NaCT (SLC13A5) that shows inhibition of citrate uptake in the HEKNaCT cells with IC50 of 0.41 uM. |
1854061-16-7 |
DC11507 |
CLP257
Featured
CLP257 (CLP-257) is a potent, selective K+-Cl- cotransporter KCC2 activator with EC50 of 616 nM; displays selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, and a panel of 55 other receptors; restores impaired Cl(-) transport i |
1181081-71-9 |
DC11942 |
VU591
A potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 0.24 uM in T1+ flux assays. |
1222810-74-3 |
DC11850 |
MK-7145
A potent, selective, and oral renal outer medullary potassium channel (ROMK) inhibitor with IC50 of 68 nM. |
1255204-84-2 |
DC11946 |
BNBI
A selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 8 uM in T1+ flux assays, does not inhibit Kir7.1 at 100 uM. |
51877-67-9 |
DC12005 |
Iberiotoxin
A selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK) with IC50 of 0.25 nM. |
129203-60-7 |
DC12006 |
Charybdotoxin
A selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK). |
95751-30-7 |
DC12003 |
Corr4A
Featured
A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM.. |
421580-53-2 |
DC12018 |
MRS 1477
A small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM). |
212200-21-0 |
DC11491 |
A-1048400
A-1048400(A 1048400) is a novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively. |
1219624-62-0 |
DC11490 |
A-317567
A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM. |
371217-32-2 |
DC7351 |
A-740003
A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). |
861393-28-4 |
DC2061 |
A-803467
Featured
A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM. |
944261-79-4 |
DC9954 |
A 804598
Featured
A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively. |
1125758-85-1 |
DC9516 |
A-867744
A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. |
1000279-69-5 |
DC9706 |
ABT-639
Featured
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50 = 2 μM) and attenuates LVA currents in rat DRG neurons (IC50 = 8 μM). |
1235560-28-7 |