| DC11942 |
VU591 |
A potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 0.24 uM in T1+ flux assays. |
|
| DC11850 |
MK-7145 |
A potent, selective, and oral renal outer medullary potassium channel (ROMK) inhibitor with IC50 of 68 nM. |
|
| DC11946 |
BNBI |
A selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 8 uM in T1+ flux assays, does not inhibit Kir7.1 at 100 uM. |
|
| DC12005 |
Iberiotoxin |
A selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK) with IC50 of 0.25 nM. |
|
| DC12006 |
Charybdotoxin |
A selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK). |
|
| DC12003 |
Corr4A
Featured
|
A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM.. |
|
| DC12018 |
MRS 1477 |
A small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM). |
|
| DC11491 |
A-1048400 |
A-1048400(A 1048400) is a novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively. |
|
| DC11490 |
A-317567 |
A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM. |
|
| DC7351 |
A-740003 |
A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). |
|
| DC2061 |
A-803467
Featured
|
A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM. |
|
| DC9954 |
A 804598
Featured
|
A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively. |
|
| DC9516 |
A-867744 |
A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. |
|
| DC9706 |
ABT-639
Featured
|
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50 = 2 μM) and attenuates LVA currents in rat DRG neurons (IC50 = 8 μM). |
|
| DC11508 |
AC1903
Featured
|
AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model. |
|
| DC7783 |
AF-353(Ro-4)
Featured
|
AF-353 is a novel, orally bioavailable, highly potent and selective P2X3/P2X2/3 receptor antagonist. |
|
| DC9026 |
Afloqualone |
Afloqualone is a agonist of GABA receptor . |
|
| DC9764 |
Afoxolaner
Featured
|
Afoxolaner is an isoxazoline that inhibits insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), blocking pre and post synaptic transfer of chloride ions across cell membranes. |
|
| DC10311 |
Allopregnanolone
Featured
|
Allopregnanolone is a progesterone metabolite. Allopregnanolone is an allosteric modulator of the GABA receptor. |
|
| DC11840 |
ALX-1393 |
ALX-1393 (ALX 1393, ALX1393) is a potent, specific GlyT2 inhibitor with Ki of <1 uM. |
|
| DC11289 |
AM-0466
Featured
|
AM-0466 is a potent and selective NaV1.7 Inhibitor (Nav 1.7 IC50 = 21 nM; Nav 1.5 IC50 =>30.0 uM. PXR = 22% @10 uM; CYP 2C9 IC50 = 4.6 uM; CYP3A4 TDI IC50 =>50.0 uM.). |
|
| DC9909 |
AM2099
Featured
|
AM-2099 is a potent and selective NaV1.7 Inhibitor. |
|
| DC11239 |
AMG-333
Featured
|
AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. |
|
| DC7055 |
AMG517
Featured
|
AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM. |
|
| DC10132 |
AMG9810
Featured
|
AMG9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). |
|
| DC9189 |
Amiodarone HCl |
Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. |
|
| DC5075 |
BDP-12(Ampalex)
Featured
|
Ampalex (Ampakine CX516) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). |
|
| DC11076 |
Ampreloxetine |
Ampreloxetine (TD-9855) is a potent monoamine reuptake inhibitor with pIC50 of 8.0, 8.6 and 6.8 for human NET, SERT, and DAT, respectively. |
|
| DC11657 |
PPT(Propyl pyrazole triol )
Featured
|
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%). |
|
| DC11649 |
Jamaicin (AnCoA4)
Featured
|
AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM. |
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