Clemizole Hydrochloride
Cat. No.: DC7387
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Chemical Structure
1163-36-6
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Field of application
Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.
| Cas No.: |
1163-36-6 |
| Chemical Name: |
Clemizole hydrochloride |
| Synonyms: |
clemizole hydrochloride;1-[4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole, Monohydrochloride;1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole,hydrochloride;Clemizole (hydrochloride);Clemizole.HCl;clemizole HCl;1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride;1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole hydrochloride;1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride;CID 2782 hydrochloride;NSC 46261 hydrochloride;1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)benzimidazole Hydrochloride;1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzoimidazole hydrochloride;Allercur;Reactrol;Allercure hydrochloride;Clemizole hydrochloride [JAN];MLS000120342;85W6I13D8M;SMR000058430;AL 20;1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole hydrochloride;DSSTox_CID_25136;DSSTox_RID_80695;DSSTox_GSID_45136;P 48;Clemizole hydrochloride (JAN);1-p-Chlorobenzyl-2-(1-pyrrolidinyl)methylbenzimidazole hydrochloride;1-(p-chlorobenzyl)-2-(1-pyrr |
| SMILES: |
ClC1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H].Cl[H] |
| Formula: |
C19H21Cl2N3 |
| M.Wt: |
362.2961 |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM. |
| In Vivo: |
Clemizole hydrochloride has an unexpectedly short plasma half-life (measured at 0.15 hours); it is very rapidly biotransformed into a glucuronide (M14) and a dealkylated metabolite (M12) and into a variety of lesser metabolites in C57BL/6J mice[3]. |
| In Vitro: |
Clemizole hydrochloride is found to inhibit HCV RNA replication in cell culture that is mediated by its suppression of NS4B’s RNA binding, with little toxicity for the host cell. The EC50 of Clemizole on the W55R mutant J6/JFH RNA is ~18 µM (2.25 times the EC50 of the wild-type RNA)[1]. Clemizole is a novel inhibitor of TRPC5 channels. Clemizole efficiently blocks TRPC5 currents and Ca2+ entry in the low micromolar range (IC50=1.0-1.3 µM). Clemizole exhibits a six-fold selectivity for TRPC5 over TRPC4β (IC50=6.4 µM), the closest structural relative of TRPC5, and an almost 10-fold selectivity over TRPC3 (IC50=9.1 µM) and TRPC6 (IC50=11.3 µM). Clemizole hydrochloride as a novel blocker of TRPC5 with a half-maximal inhibitory concentration of 1.1 µM. The concentration-response curves confirmed a concentration-dependent block of TRPC5 by Clemizole and revealed an apparent IC50 of 1.1±0.04 µM[2]. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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