| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC8976 | Aniracetam | Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR. |
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| DC11196 | AP14145 | AP14145 (AP-14145) is a potent, selective negative allosteric modulator of KCa2.2 and KCa2.3 with equal potency (IC50=1.1±0.3 uM). |
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| DC10558 | ASP 7663 Featured | ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). |
|
| DC9034 | Atomoxetine HCl | Atomoxetine Hcl(LY 139603; Tomoxetine Hcl) is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). |
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| DC11999 | AUT-1 Featured | AUT-1 is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively. |
|
| DC9263 | AZD-3965 Featured | AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 μM. |
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| DC10425 | AZD9056 hydrochloride | AZD9056 is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases. |
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| DC9596 | Azimilide (Dihydrochloride) | Azimilide 2Hcl(NE-10064 2Hcl) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. |
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| DC10992 | Azosemide | Azosemide (Azosemidum) is a potent Na-K-Cl Cotransporter NKCC1 with IC50 of 0.246 and 0.197 uM for hNKCC1A and NKCC1B, being about 4-times more potent than bumetanide. |
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| DC12033 | (S)-B-973B Featured | B-973 (B973) is a potent, selective α7 nAChR ago-PAM, denonstrates analgesic effect with attenuating pain behavior and decreasing paw edema in vivo. |
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| DC8971 | Baclofen | Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. |
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| DC9869 | Bamaquimast | Bamaquimast is an inhibitor of proton pump extracted from patent US2005165041, example 138. |
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| DC9935 | Basmisanil(RG1662) Featured | Basmisanil is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors which is under development by Roche for the treatment of cognitive impairment associated with Down syndrome. |
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| DC11218 | BAY-8002 Featured | BAY-8002 is a novel potent, selective, orally available monocarboxylate transporter 1 (MCT1) inhibitor (Kd=7.9 nM). |
|
| DC10107 | BAY-876 Featured | BAY-876 is the first highly selective GLUT1 inhibitor with IC50 of 0.002 uM. show good metabolic stability in vitro and high oral bioavailability in vivo. |
|
| DC9826 | BCTC Featured | BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
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| DC8186 | Bexagliflozin3 Featured | Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively. |
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| DC8882 | Bitopertin Featured | Bitopertin, also known as RG1678, is a potent and selective inhibitor of GlyT1 with an EC50 of 30nM. |
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| DC8457 | BMS-309403 Featured | BMS309403 is orally active, reducing atherosclerosis in mice lacking apoplipoprotein E. |
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| DC10387 | BPO-27 racemat | BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. |
|
| DC10605 | Brevianamide F Featured | Brevianamide F , also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. |
|
| DCAPI1140 | Bumetanide Featured | Bumetanide |
|
| DC3111 | Canagliflozin Featured | Canagliflozin is a highly potent and selective SGLT2 inhibitor for CHO-hSGLT2, CHO-rSGLT2 and CHO-mSGLT2 with IC50 of 4.4 nM, 3.7 nM and 2 nM, respectively. |
|
| DC9193 | Carbamazepine Featured | Carbamazepine, a sodium channel blocker, is an anticonvulsant drug. |
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| DC7990 | Cariporide | Cariporide is a selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). |
|
| DC10948 | CDN1163 Featured | CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes; increases Ca2+-ATPase activity and significantly enhances Ca2+ uptake into the ER, attenuates H2O2-stimulated cell death in HEK cells; improves glucose homeostasis and metabolic parameters, increases glucose tolerance in ob/ob mice; CDN1163 reduces lipid accumulation and decreases lipogenesis in obese mice livers. |
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| DC9340 | CFM-2 | CFM-2 is a selective non-competitive AMPAR antagonist. |
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| DC7039 | CFTR Inhibitor II Featured | CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells. |
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| DC10843 | CGP 52432 Featured | CGP 52432 is a potent, selective GABAB receptor antagonist (IC50 = 85 nM). |
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| DC9849 | CGP37849 | CGP37849 is a potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). Anticonvulsive following oral administration in vivo. |
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