| DC74518 |
U7D-1 |
U7D-1 is a selective USP7-degrading Proteolysis Targeting Chimera (PROTAC). U7D-1 showed selective and effective USP7 degradation, and maintained potent cell growth inhibition in p53 mutant cancer cells. |
|
| DC74519 |
UBX-382 |
UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM. |
|
| DC74520 |
UNC7700 |
UNC7700 (UNC-7700) is a potent EED-targeted PRC2 degrader, contains a unique cis-cyclobutane linker and potently degrades all PRC2 components EED (DC50=111 nM; Dmax=84%), EZH2WT/EZH2Y641N (DC50=275 nM; Dmax=86%) and SUZ12 (Dmax=44%) in DLBCL cells. |
|
| DC74521 |
WD6305 |
WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line. |
|
| DC74523 |
XY-07-35
Featured
|
XY-07-35 is a potent, selective HDAC6 proteolysis targeting chimera (PROTAC) degrader with IC50 of 48.5 nM. |
|
| DC74524 |
YX968 |
YX968 is a potent, selecive HDAC3/8 dual PROTAC degrader with DC50 of 1.7 and 6.1 nM in degrading HDAC3 and HDAC8 respectively (MDA-MD-231 cell, 8 h). |
|
| DC74525 |
ZZ151 |
ZZ151 (ZZ-151) is a highly potent and selective SOS1 degrader PROTAC with DC50 of 15.7 nM (Dmax=100%). |
|
| DC74526 |
AdipoAI |
AdipoAI is a novel small molecule APN receptor (AdipoR, adiponectin receptor) agonist. |
|
| DC74527 |
ALY688 |
ALY688 (ADP 355) is an adiponectin mimetic adiponectin receptor (AdipoR) agonist, inhibits the growth of AdipoR1/AdipoR2-positive cancer cell lines (MCF-7 cell, 0.1-10 uM). |
|
| DC74528 |
K284
Featured
|
K284 is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals. |
|
| DC74529 |
Wyeth-1 |
Wyeth-1 (hAMCase inhibitor 1) is a potent, selective inhibitor of human acidic mammalian chitinase (hAMCase) with IC50 of 210 nM, 20-fold selectivity over hCHIT1. |
|
| DC74530 |
DL5050 |
DL5050 (DL 5050) is a potent selective agonist of human constitutive androstane receptor (CAR) with EC50 of 0.37 uM in cell-based luciferase reporter assays (Emax=3.8). |
|
| DC74531 |
DL7076 |
DL7076 (CN06) is a small molecule dual activator of the constitutive androstane receptor (CAR, NR1I3) and nuclear factor erythroid 2-related factor 2 (Nrf2) with EC50 of 8.85 and 0.72 uM, respectively. |
|
| DC74532 |
BVT173187 |
BVT173187 is a potent, selective, non-peptide inhibitor of formyl peptide receptor 1 (FPR1), inhibits fMLF and WKYMVM induced oxidase activity. |
|
| DC74533 |
ICT12035 |
ICT12035 (AZ2158) is a potent, selective formylpeptide receptor-1 (FPR1) antagonist with IC50 of 30 nM in calcium mobilisation assays (100 nM fMLF). |
|
| DC74534 |
MD102 |
MD102 is a potent transglutaminase 2 (TGase 2; TG2) inhibitor with IC50 of 0.35 uM, shows p53 stabilization effect and anticancer activity at RCC cell lines. |
|
| DC74535 |
ZED1227 |
ZED1227 is a potent, selective, covalent, and orally active transglutaminase 2 (TGase 2, TG2) inhibitor with IC50 of 45 nM. |
|
| DC74536 |
LJ4827 |
LJ4827 (LJ-4827) is a potent, specific inhibitor of HASPIN, a mitotic kinase for Histone H3, with Ki value of 0.46 nM, enzyme IC50 of 0.155 nM in HASPIN kinase assay performed with Histone H3 peptide. |
|
| DC74537 |
AG-120-X |
AG-120-X is a first-in-class small molecule inhibitor of ICOS/ICOSL interaction with IC50 of 4.68 uM in TR-FRET assay, dose-dependently blocks ICOS/ICOSL interaction in cellular assay based on co-culturing Jurkat T cells expressing ICOS and CHO-K1 cells e |
|
| DC74538 |
C-5401331 |
C-5401331 is a small molecule T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) inhibitor, suppresses acute myeloid leukemia (AML) cell proliferation. |
|
| DC74539 |
L557-0155
Featured
|
L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth. |
|
| DC74540 |
MTX-3937
Featured
|
MTX-3937 is a small-molecule inhibitor targeting Siglec-9 (Sialic acid-binding immunoglobulin-type lectin-9), a member of the Siglec family of immunomodulatory receptors. Siglec-9 is primarily expressed on immune cells, such as myeloid cells and natural killer (NK) cells, and plays a role in regulating immune responses by transmitting inhibitory signals through its intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs). |
|
| DC74541 |
ARUK3001185 |
ARUK3001185 is a potent, selective, brain-penetrant inhibitor of Wnt-deactivating enzyme Notum carboxylesterase activity with IC50 of 6.7 nM in OPTS biochemical assay. |
|
| DC74542 |
LP-914822 |
LP-914822 (LP914822) is a potent, selective and orally-active NOTUM with IC50 of 2 nM for human, mouse and rat Notum. |
|
| DC74543 |
LP-935001 |
LP-935001 (LP935001) is a potent, selective and orally-active NOTUM with enzyme IC50 of 0.4 nM for both of human and mouse Notum. |
|
| DC74544 |
AS-48 |
AS-48 is a specific, small-molecule measles virus (MeV) entry inhibitor with IC50 of 0.6 uM agianst MV-KS. |
|
| DC74545 |
MBZM-N-IBT |
MBZM-N-IBT is a small molecule inhibitor of Chikungunya virus (CHIKV), inhibits CHIKV infection in vitro in RAW 264.7 cells with IC50 of 22.34 uM, targets CHIKV nsP2 protease activity. |
|
| DC74546 |
SBI-0090799 |
SBI-0090799 (SBI 0090799) is a selective and potent inhibitor of Zika virus (ZIKV) replication, inhibits replication of multiple ZIKV strains and in different cell systems. |
|
| DC74547 |
UMM-766 |
UMM-766 is an orally available nucleoside analog with potent, broad-spectrum antiviral activity against multiple members of orthopoxviruses (EC50<1 uM against VACV). |
|
| DC74548 |
USC-373 |
USC-373 is a phosphonate prodrug of HPMPC (cidofovir) with activity against VZV and other DNA viruses. |
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