Cat. No. | Product name | CAS No. |
DC23613 |
GX-936
GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM. |
1235406-09-3 |
DC5061 |
GYKI 52466 dihydrochloride
GYKI 52466 dihydrochloride is a selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. |
102771-26-6 |
DC22106 |
GZ389988
GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis. |
1788906-96-6 |
DC20118 |
GZD856
GZD856 is a novel and orally bioavailable PDGFRα/β inhibitor with IC50s of 68.6 and 136.6 nM, respectively. Anti-lung cancer activities. Also a Bcr-AblT315I inhibitor with IC50s of 19.9 and 15.4 nM for Bcr-Abl and T315I mutant. |
1257628-64-0 |
DC11010 |
H3B-5942
H3B-5942 is an orally available, selective estrogen receptor covalent antagonist (SERCA), demonstrates potent ERαantagonist activity in vitro and in vivo. |
2052128-15-9 |
DC21105 |
H3B-8800
Featured
H3B8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WT or mutant SF3B1 (binding IC50 of 0.3-2 nM),demonstrates dose-dependent inhibition of both canonical splicing and aberrant splicing induced by mutant SF3B1 in in vitro assays of biochemical splicing, induces lethality in spliceosome-mutant cancer cells.. H3B-8800 potently and preferentially kills spliceosome-mutant epithelial and hematologic tumor cells. |
1825302-42-8 |
DC12266 |
H4 Receptor antagonist 1
H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM. |
848217-00-5 |
DC20106 |
H4R antagonist 1
H4R antagonist 1 |
1429375-54-1 |
DC1066 |
HA14-1
Featured
HA14-1 is a nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of~9 μM. |
65673-63-4 |
DC9567 |
Halcinonide
Halcinonide is a high potency corticosteroid used topically in the treatment of certain skin conditions. |
3093-35-4 |
DC9749 |
Halofuginone
Halofuginone is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal. |
55837-20-2 |
DC10935 |
HAMI3379
HAMI3379 (HAMI-3379) is a potent and selective antagonist of cysteinyl leukotriene 2 (CysLT(2)) receptor, inhibits LTD4- and LTC4-induced intracellular calcium mobilization withIC50 of 3.8 nM and 4.4 nM respectively. |
1245653-57-9 |
DC21106 |
HAP-12
HAP-12 is a small molecule HBV capsid assembly effector that inhibits HBV DNA replication with EC50 of 0.5 uM.. |
1078164-85-8 |
DC23253 |
HAR-171
HAR-171 is a small molecule gp120-CD40 blocker that acts as a highly potent HIV entry inhibitor with IC50 of 0.43 uM against YTA48P virus with no significant cytotoxicity (CC50>120 uM).. |
1349902-37-9 |
DC12224 |
H-Arg-4MβNA
H-Arg-4MβNA is a substrate for cathepsin H, used for the detection of enzyme activity in gel electrophoresis. |
60285-94-1 |
DC23634 |
HBT1
HBT1 is a novel potent AMPA receptor potentiator with lower agonistic effect compared with LY451395 and OXP1.. |
489408-02-8 |
DC20917 |
HBV Capsid inhibitor 3711
HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation. |
2041072-40-4 |
DC10354 |
HBX 19818
Featured
HBX 19818 is a selective USP7 inhibitor with IC50 of 28.1 uM . |
1426944-49-1 |
DC23783 |
HBX 28258
HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1. |
1426544-54-8 |
DC12197 |
HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide)
HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na+]i rise is slowed by HC-056456 (IC50~3 µM). |
7733-96-2 |
DC21108 |
HC-070
HC-070 is a potent, selective, orally active inhibitor of TRPC4 and TRPC5 channel with IC50 of 9.3 and 46 nM (calcium influx inhibition), respectively. |
1628291-95-1 |
DC10932 |
HDAC6 degrader 9c
HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand. |
2235382-05-3 |