Cat. No. | Product name | CAS No. |
DC21521 |
PNU-112455A
Featured
PNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively, shows no activity against c-c-Met, IGR-1R, and ERK2.. |
21886-12-4 |
DC7648 |
PNU159682
Featured
PNU-159682 is a major bioactive metabolite of Nemorubicin in human liver microsomes; > 3,000-fold cytotoxic than its parent compound(MMDX and doxorubicin). |
202350-68-3 |
DC10409 |
PNU-74654
PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell. |
113906-27-7 |
DC11373 |
Polmacoxib
Polmacoxib is an inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrase subtypes I (CAI) and CAII. |
301692-76-2 |
DC26094 |
Poloppin II
Poloppin II is an orally active, Poloppin derivative inhibitor of protein-protein interaction via the PBD of the mitotic Polo-like kinase (PLK) with IC50 of 41 uM in FP assays, exhibits IC50 of 61 nM cellular assay for mitotic arrest. |
|
DC9594 |
Poloxin
Featured
Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain. |
321688-88-4 |
DC10214 |
Polymyxin B sulphate
Featured
Polymyxin B is an antibiotic primarily used for resistant gram-negative infections. |
1404-26-8 |
DC22413 |
Pomaglumetad Methionil
Pomaglumetad Methionil (LY2140023 monohydrate) is the methionine amide prodrug of the mGluR2/3 agonist LY-404039 with the potential oral treatment of schizophrenia.. |
635318-55-7 |
DC26122 |
Pomalidomide-C2-NH2 hydrochloride
Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. |
2305369-00-8 |
DC11914 |
Poseltinib
Featured
Poseltinib (HM-71224, LY-3337641) is a potent and selective, covalent inhibitor of Btk with IC50 of 1.95 nM. |
1353552-97-2 |
DC20217 |
Potassium thioacetate
Potassium thioacetate is widely used as a sulfur source in the synthesis of sulfur-containing organic compounds. It has been employed for the synthesis of heterocycles, polymers, transition-metal ligands, nanoparticles, bioactive compounds and macromolecu |
10387-40-3 |
DC7492 |
SB 258585 hydrochloride
Potent and selective 5-HT6 receptor antagonist (pKi = 8.6). |
1216468-02-8 |
DC8022 |
R-268712
Featured
Potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 = 2.5 nM). Exhibits ~ 5000-fold selectivity over p38 MAPK. Suppresses development of renal fibrosis in a unilateral ureteral obstruction model. Also reduces proteinuria, glomeruloscler |
879487-87-3 |
DC8603 |
SR 49059
Featured
Potent and selective non-peptide vasopressin V1A receptor antagonist; devoid of agonist activity. Displays high affinity and efficacy at both rat (KI=1.6 nM) and human (KI -1.1 - 6.3 nM) V1A receptors. |
150375-75-0 |
DC8604 |
Pim-1 Inhibitor 2
Potent Pim-1 kinase inhibitor (Ki = 91 nM). |
477845-12-8 |
DC7370 |
AZ-628
Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM For c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity For Raf kinases over a panel of 150 other kinases. |
878739-06-1 |
DC12421 |
PP1 inhibitor C31
PP1 inhibitor C31 is a 1E7-03 analog and protein phosphatase 1 (PP1) targeting small molecule with Kd of 1.88 uM, inhibits Ebola virus (EBOV) transcription and replication. |
|
DC8742 |
PP121
PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM. |
1092788-83-4 |
DC23712 |
PPARα activator compound 3
PPARα activator compound 3 is a specific PPAR activator that selectively up-regulates PPARα transcriptional activity, leading to PPARα target gene expression both in vitro and in vivo. |
1011399-77-1 |
DC23517 |
PPBI
PPBI is a novel potent, selective, full M1 muscarinic agonist with EC50 of 5, 8, and 21 nM for human, rat, and mouse M1 receptors, respectively. |
959863-95-7 |
DC21525 |
PPI-2458
PPI-2458 is potent, specific, irreversible methionine aminopeptidase-2 (MetAP-2) inhibitor with IC50 of 0.2 nM, inhibits growth inhibition of HFLS-RA and HUVEC with IC50 of 0.04 nM. |
431077-35-9 |
DC21943 |
PPTN trifluoroacetate salt
PPTN is a potent, highly specific amtagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays. |
2187367-09-3 |