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| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC23412 | BMS-955829 | A potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM). |
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| DC22804 | CMPD-1 | A potent, selective, non-ATP-competitive inhibitor of p38α-mediated MK2a phosphorylation with apparent Ki of 330 nM. |
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| DC22742 | KAB-18 | A potent, selective, noncompetitive human α4β2 nAChRs negative allosteric modulator with IC50 of 13.5 uM, displays no inhibitory activity on Hα3β4 nAChRs at 100 uM.. |
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| DC23195 | CBR-5884 Featured | A potent, selective, noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) with IC50 of 7 uM. |
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| DC11746 | JNJ-27141491 | A potent, selective, noncompetitive, orally active CCR2 antagonist with IC50 of 172 nM. |
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| DC22449 | PD-146176 | A potent, selective, non-competitve inhibitor of 15-lipoxygenase (15-LOX) with Ki of 197 nM. |
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| DC22447 | FAAH-IN-2 | A potent, selective, noncovalent FAAH inhibitor with IC50 of 28 nM toward human FAAH and 100 nM toward rat FAAH. |
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| DC11756 | SR 140333 | A potent, selective, non-peptide NK1 receptor antagonist with Ki of 0.74 nM, IC50 of 1.6 nM. |
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| DC22680 | Conivaptan | A potent, selective, nonpeptide vasopressin V1A and V2 receptor antagonist with Ki of 0.48 nM and 3.04 nM respectively. |
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| DC21738 | TBC3486 | A potent, selective, non-peptidic integrin α4β1 (VLA-4) antagonist with IC50 of 9 nM, displays 200-fold selectivity over α4β7 (IC50=2.1 uM). |
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| DC20617 | AA-CW236 Featured | A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency. |
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| DC21593 | RUC-4 Featured | A potent, selective, non-RGD-mimetic αIIbβ3 integrin receptor antagonist with IC50 of 45 nM, with no activity on αVβ3 receptors. . |
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| DC23596 | Luseogliflozin | A potent, selective, orally acitve SGLT2 inhibitor with IC50 of 2.26 nM, 1650-fold selectivity over SGLT1. |
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| DC21307 | MKC-733 | A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors. |
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| DC11667 | PF-592379 | A potent, selective, orally active agonist of dopamine D3 receptor with EC50 of 21 nM. |
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| DC21606 | SB-357134 | A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes. |
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| DC20774 | VTP 37948 | A potent, selective, orally active BACE1 inhibitor for the treatment of Alzheimer's disease.. |
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| DC20665 | AMG 8718 | A potent, selective, orally active BACE1 inhibitor with IC50 of 0.7 nM, demonstrates limited selectivity for over BACE2 and high selectivity both renin and pepsin. |
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| DC20324 | BRS-3 agonist Compound A | A potent, selective, orally active bombesin receptor subtype-3 (BRS-3) agonist with EC50 of 250/100 nM for human/rat BRS-3, resp+H1437+M1438. |
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| DC20325 | BRS-3 agonist Compound A racemate | A potent, selective, orally active bombesin receptor subtype-3 (BRS-3) agonist with EC50 of 270/130 nM for human/rat BRS-3, respectively. |
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| DC21187 | JTE907 Featured | A potent, selective, orally active cannabinoid CB2 receptor inverse agonist with Ki of 35.9, 1.55 and 0.38 nM for human, mouse and rat CB2, respectively. |
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| DC21793 | VER-250840 | A potent, selective, orally active Chk1 inhibitor with IC50 of < 1 nM, Ki=69 pM. |
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| DC22898 | L-365260 | A potent, selective, orally active cholecystokinin receptor 2 (CCK2) antagonist with IC50 of 2 nM. |
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| DC22485 | Gefitinib hydrochloride Featured | A potent, selective, orally active EGFR inhibitor with IC50 of 23 nM. |
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| DC21443 | ONO-5334 | A potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. |
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| DC23340 | CCT-251455 | A potent, selective, orally active monopolar spindle 1 (MPS1) inhibitor with IC50 of 3 nM, with no activity for CDK2 and Aurora A (IC50>40 uM). |
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| DC11704 | CFI-401870 | A potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM. |
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| DC25200 | PF-1355 Featured | PF-1355 is a potent, selective, orally active Myeloperoxidase (MPO) inhibitor with EC50 of 1.47 uM. |
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| DC22900 | MLE-4901 Featured | A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia. |
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| DC22664 | Fezolinetant Featured | Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes. |
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