DC74038 |
JBSNF-000028 |
JBSNF-000028 (JBSNF000028) is a potent, selective, orally bioavailable substrate-analog inhibitor of nicotinamide N-methyltransferase (NNMT) with IC50 of 34 nM, 190 and 210 nM against human, monkey and mouse NNMT, respectively. |
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DC74039 |
JNJ 74856665 |
JNJ74856665 (JNJ74856665) is an orally available, potent and selective DHODH inhibitor with IC50 values in the subnanomolar range. |
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DC74040 |
JNJ-54302833 |
JNJ-54302833 (JNJ 54302833) is a potent, selective fatty acid synthase (FASN) inhibitor with IC50 of 28 nM. |
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DC74041 |
JSD26 |
JSD26 is a selective S-nitroso-coenzyme A reductase 2 (SCoR2; AKR1A1) inhibitor with Ki of 93 nM, 10-fold selectivity over AKR1B1. |
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DC74042 |
JumOCA peptide |
JumOCA peptide (VKELLRRKRGH) is a peptide corresponding to the OCA-B N terminus, membrane-penetrating OCA-B peptide inhibitor. |
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DC74043 |
JumOCA peptide Tat |
JumOCA peptide Tat is a a peptide corresponding to the OCA-B N terminus, as C-terminal fusions to the HIV trans-activator of transcription (Tat) protein for membrane permeability. |
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DC74044 |
JYFY-001 |
JYFY-001 is a small molecule copper chelator with moderate selectivity for targeting copper, potently inhibits cancer proliferation. |
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DC74045 |
JYQ-88 |
JYQ-88 is a potent, selective and covalent PARK7 inhibitor with IC50 of 0.13 uM in DiFMUAc assays, 100-fold selectivity over UCHL1 (PARK5, IC50=11.1 uM), covalently modifies the active site Cys106. |
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DC74046 |
K786-4469 |
K786-4469 is a small molecule inhibitor of anoctamin 1 (ANO1), suppresses cancer metastasis in vitro and in vivo. |
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DC74047 |
Kakeimide
Featured
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Kakeimide is a potent GH3 inhibitor that selectively targets IAA-conjugating GH3 proteins at subnanomolar concentrations in vitro, shows auxin-like activity by inhibiting endogenous IAA catabolism. |
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DC74048 |
Karyostatin 1A |
Karyostatin 1AKaryostatin 1A is a small molecule inhibitor of importin beta with binding affinity (Kd=0.3 uM), selectively inhibits the importin α/β pathway. |
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DC74049 |
KBP-066 |
KBP-066 is a potent, selective dual amylin and calcitonin receptor agonist induces an equally potent body weight loss across a broad dose range in obese rats. |
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DC74050 |
KIO-100 |
KIO-100 (PP-001) is a novel potent, specific small molecule inhibitor of DHODH with IC50 of <4 nM, 150-fold higher potency than leflunomide (IC50 of 650 nM). |
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DC74051 |
KL101 |
KL101 (KL 101) is a isoform-selective small molecule stabilizer of Cryptochrome 1 (CRY1). |
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DC74052 |
KP-1019 |
A ruthenium complex anticancer agent that is useful for metastatic tumors and cis-platin resistant tumors. |
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DC74053 |
KP-1339 |
A promising ruthenium anticancer compound that blocks angiogenesis, endothelial cell proliferation and migration stimulated by VEGF or NO donor agent. |
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DC74054 |
KRP-6 |
KRP-6 is a potent and highly selective macrophage migration inhibitory factor (MIF) ketonase inhibitor with IC50 of 4.31 uM, significantly reduces MIF-induced neutrophil migration. |
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DC74055 |
KS10076 |
KS10076 is a metal chelator with potent anti-cancer cytotoxicity, destabilizes STAT3 by elevating ROS, shows remarkable cytotoxic efficacy in 100 cancer cell lines of different types with IC50 of <1 uM. |
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DC74056 |
KVS0001 |
KVS0001 is a specific and bioavailable small molecule inhibitor of SMG1 kinase, disrupts nonsense mediated decay (NMD). |
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DC74057 |
KZR-8445 |
KZR-8445 (KZR8445) is a cyclic depsipeptide, client-selective Sec61 inhibitor with IC50 of 100 nM, targets the Sec61 translocon and selectively modulate Sec61-mediated protein biogenesis. |
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DC74058 |
L6H21 |
L6H21 is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor with binding KD value of 33.3 uM, blocks the formation of the LPS-TLR4/MD-2 complex. |
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DC74059 |
LI-2242 |
LI-2242 is a potent pan-IP6K inhibitor with IC50 of with IC50 of 31, 42 and 8.1 nM for IP6K1, IP6K2 and IP6K3, respectively. |
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DC74060 |
LP-403812 |
LP-403812 is a specific small molecule inhibitor of mammalian proline transporter (PROT), inhibits PROT-mediated proline uptake with IC50 of 0.1 uM on both recombinant human and mouse PROT. |
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DC74061 |
LSALT peptide |
Metablok (LSALT peptide) is a specific DPEP1-binding peptide and nonenzymatic dipeptidase-1 (DPEP-1) inhibitor. |
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DC74062 |
L-Thyroxine sodium salt pentahydrate |
A manufactured form of the thyroid hormone thyroxine (T4) that typically used to treat hypothyroidism. |
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DC74063 |
LX-6171 |
LX-6171 is a small molecule proline transporter (SLC6A7) inhibitor with potential for treating cognitive and other disorders. |
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DC74064 |
Macrocyclic peptide D4-2
Featured
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Macrocyclic peptide D4-2 is a macrocyclic peptide consisting of 15 amino acids that binds to the ectodomain of mouse SIRPα (Kd=10 nM, IgV-B6 SIRPα) and efficiently blocks CD47-SIRPα interaction in an allosteric manner (IC50=0.18 uM). |
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DC74065 |
MASM7 |
MASM7 is a small molecule activator of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively increases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 75 nM, directly and specifically modulates MFN1/2 fusogenic activity |
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DC74066 |
MCI-100 |
MCI-100 is a small molecule that displays greater potency than sulindac to protect RPE cells against oxidative damage, with lacked significant COX inhibitory activity, MCI-100 is more active than sulindac in protecting cells against oxidative damage. |
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DC74068 |
MEISi-1 |
MEISi-1 (MEIS inhibitor 1) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity. |
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