| DC8322 |
Anacardic Acid
Featured
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Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF) with IC50 values of 8.5 and 5 µM, respectively. |
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| DC7804 |
Anacetrapib(MK0859)
Featured
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Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3. |
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| DC9429 |
Anagliptin |
Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9.
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|
| DC9580 |
Anagrelide (hydrochloride) |
Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.
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|
| DC7357 |
Anamorelin
Featured
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Anamorelin(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia. |
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| DCAPI1425 |
Anastrozole
Featured
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Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition. |
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| DC11649 |
Jamaicin (AnCoA4)
Featured
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AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM. |
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| DC8122 |
Andarine (GTX-007,S-4)
Featured
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GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity. |
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| DC20085 |
Androgen receptor modulators 1 |
Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM. |
|
| DC12143 |
Anemarrhenasaponin I |
Anemarrhenasaponin I, a traditional Chinese medicine, is isolated from Anemarrhena asphodeloides Bunge. |
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| DC12113 |
Anemarsaponin E |
Anemarsaponin E is extracted from Anemarrhena asphodeloides Bunge and has anti-inflammatory activity. |
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| DC24123 |
Angiotensin 1-7 |
Angiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM. |
|
| DC9348 |
Angiotensin II human |
Angiotensin II human is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.
|
|
| DC24109 |
Anguizole |
Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2), blocks genotype 1b HCV replication with EC50 of 310 nM. |
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| DCAPI1490 |
Anidulafungin
Featured
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Anidulafungin |
|
| DC8976 |
Aniracetam |
Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR. |
|
| DC10168 |
Anle138b
Featured
|
Anle138b is a novel oligomer modulator. |
|
| DC8802 |
Maytansinol(Ansamitocin P-0)
Featured
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Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro. Target: Microtubule/Tubulin in vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug. |
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| DC8241 |
Ansamitocin P-3
Featured
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Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. |
|
| DC20670 |
ANT431
Featured
|
ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively). |
|
| DC20671 |
ANT431 sodium |
ANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively). |
|
| DC11088 |
Fosmanogepix |
antifungal. |
|
| DC23276 |
Antimalarial compound 49c |
Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM. |
|
| DC20308 |
Antimycin A |
Antimycin A is an inhibitor of cellular respiration, specifically oxidative phosphorylation, binds to the Qi site of cytochrome c reductase, disrupts the Q-cycle of enzyme turn over. |
|
| DC8959 |
Antipyrine |
Antipyrine is an analgesic and antipyretic agent |
|
| DC22094 |
ANY1 |
ANY1 (FosA inhibitor ANY1) is a small molecule active site inhibitor of FosA (metal-dependent glutathione S-transferase) with IC50 of 5.1 uM (K. pneumoniae FosA). |
|
| DC10950 |
AOH1160 |
AOH1160 is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA). |
|
| DC11196 |
AP14145 |
AP14145 (AP-14145) is a potent, selective negative allosteric modulator of KCa2.2 and KCa2.3 with equal potency (IC50=1.1±0.3 uM). |
|
| DC20078 |
AP1867
Featured
|
AP1867 is a synthetic FKBP12F36V-directed ligand. |
|
| DC22207 |
AP1903
Featured
|
AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM. |
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