| DC1020 |
Ponatinib (AP24534)
Featured
|
AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively. |
|
| DC5198 |
ALK-IN-1 (Brigatinib analog)
Featured
|
ALK-IN-1 (Brigatinib analog) is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1. |
|
| DC12705 |
APA modulator T4 |
APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts. |
|
| DC12706 |
APA modulator T5 |
APA modulator T5 is a small modulator of alternative polyadenylation (APA), modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts. |
|
| DC12636 |
Apararenone
Featured
|
Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.. |
|
| DC4101 |
Apatinib Mesylate
Featured
|
Apatinib (YN968D1) is an orally bioavailable, selective VEGFR2 inhibitor with IC50 of 1 nM. |
|
| DC8465 |
Apatinib (free base)
Featured
|
Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. |
|
| DC20310 |
Apcin
Featured
|
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. |
|
| DC11428 |
Olorinab |
APD-371 (APD371, Olorinab) is a potent, selective and orally available CB2 agonist with EC50 of 6.2 nM; displays no activity against CB1 receptors (EC50>10 uM); exhibits activity in rat model of osteoarthritis pain. |
|
| DC8804 |
APD597(JNJ-38431055)
Featured
|
APD597(JNJ-38431055) is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. |
|
| DC22430 |
APD916 |
APD916 is a potent and selective antagonist of the H3 receptor with Ki of 0.7 nM for rH3R. |
|
| DC11077 |
Azelaprag |
apelin receptor. |
|
| DC21448 |
Apicidin
Featured
|
Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay. |
|
| DC8275 |
Apilimod
Featured
|
Apilimod(STA 5326) is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. |
|
| DC8276 |
Apilimod mesylate
Featured
|
Apilimod(STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. |
|
| DC5114 |
Apixaban (BMS 562247-01)
Featured
|
Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. |
|
| DC23406 |
Aplaviroc |
Aplaviroc (GSK-873140. |
|
| DC23522 |
Aplaviroc HCl
Featured
|
Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5 (CCR5) and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5. |
|
| DC6901 |
Daporinad(FK866,APO866)
Featured
|
APO866 effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM. |
|
| DC25100 |
Apogossypol |
Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively. |
|
| DC23901 |
R-(-)-Apomorphine
Featured
|
Apomorphine hydrochloride hemihydrate is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.. |
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|
| DC2066 |
Apoptosis Activator 2
Featured
|
Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells. |
|
| DC10122 |
Apoptozole
Featured
|
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. |
|
| DC7063 |
Apremilast
Featured
|
Apremilast(CC10004) is a novel small molecule inhibitor of PDE4 with an IC50 value of 74 nM. |
|
| DC7003 |
Apricitabine |
Apricitabine is a novel nucleoside reverse transcriptase inhibitor for the treatment of HIV infection that is refractory to existing drugs |
|
| DC11513 |
Aprocitentan (ACT-132577)
Featured
|
Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting. |
|
| DC10207 |
Aprotinin |
Aprotinin is a serine protease inhibitor isolated from bovine lung which inhibits trypsin and chymotrypsin with Ki values of 0.06 pM and 9 nM, respectively. |
|
| DC10048 |
APS-2-79
Featured
|
APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM |
|
| DC9808 |
APS-2-79 hydrochloride
Featured
|
APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM |
|
| DC9809 |
APS-3-77 HCl
Featured
|
APS-3-77 is the negative binder of KSR2. |
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