| DC66339 |
N-Desmethyl-U-47700
Featured
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N-Desmethyl-U-47700 is the primary metabolite of U-47700 (an opioid agonist). |
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| DC66340 |
CZL80
Featured
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CZL80, a brain-penetrable caspase-1 inhibitor with an IC50 of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility. |
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| DC66341 |
P2X4 antagonist-1
Featured
|
P2X4 antagonist-1 (Compound 24) is an antagonist for P2X4 with IC50 of 15 nM. |
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| DC66342 |
N-Benzyl-6-chloropyrimidin-4-amine
Featured
|
N-Benzyl-6-chloropyrimidin-4-amine is a pyrimidine derivative. |
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| DC66343 |
Antiviral agent 52
Featured
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Antiviral agent 52 (Compound 30) is a Chlorcyclizine (HY-112067) derivative that exhibits antiviral activity against hepatitic C virus (HCV) with an EC50 of 17 nM. Antiviral agent 52 reveals cytotoxicity in cell Huh7.5.1 with CC50 of 21.3 μM. |
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| DC66344 |
(E/Z)-MCB-613
Featured
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(E/Z)-MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. (E/Z)-MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. (E/Z)-MCB-613 is a cytotoxic molecule that plays an important role in cancer. |
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| DC66345 |
CAY10464
Featured
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CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a Ki of 1.4 nM. |
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| DC66346 |
11β-HSD2-IN-2
Featured
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11β-HSD2-IN-2 (compound 3) is a selective inhibitor for 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) with an IC50 of 300 nM. |
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| DC66347 |
HDL-16
Featured
|
HDL-16 is a potent P2Y14R antagonist with an IC50 of 0.3095 nM. HDL-16 ameliorates DSS (HY-116282C)-induced colitis through suppressing necroptosis of intestinal epithelium cells (IECs) and protecting mucosal barrier function. |
|
| DC66348 |
Scarlet 808
Featured
|
Scarlet 808 (Bronze Red; Shanghai Bronze Red) is a naphthol red pigment. Scarlet 808 can be used for coloring coatings, leather, and latex paints. It has the advantages of high tinting power, good hiding power, alkali resistance, and acid resistance. |
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| DC66349 |
EBV lytic cycle inducer-1
Featured
|
Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers. |
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| DC66350 |
LM-41
Featured
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LM-41 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2. LM-41 inhibits migration of human MDA-MB-231 breast cancer cells. |
|
| DC66351 |
NorA-IN-1
Featured
|
NorA-IN-1 (Compound 16) is a NorA inhibitor. NorA-IN-1 inhibits NorA efflux pump in everted membrane vesicles. NorA-IN-1 can be used for research of multidrug resistance. |
|
| DC66352 |
Methyl 3,4-dimethoxycinnamate
Featured
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Methyl 3,4-dimethoxycinnamate is an inhibitor of uredospore germination. Methyl 3,4-dimethoxycinnamate also inhibits global DNA methylation in in Hep3B cells. |
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| DC66353 |
Methyl 3,4,5-trimethoxycinnamate
Featured
|
Methyl 3,4,5-trimethoxycinnamate (Compound III) is a natural compound with hydroxyl radical-scavenging effects. |
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| DC66354 |
RIOK2-IN-1
Featured
|
RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression. |
|
| DC66355 |
hRIO2 kinase ligand-1
Featured
|
hRIO2 kinase ligand-1 (com 9) is a ligand of hRIO2 kinase, with a Kd value of 520 nM. |
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| DC66356 |
(E)-Benzyl ferulate
Featured
|
(E)-Benzyl ferulate is a phenolic ester that can be isolated from Thai propolis. |
|
| DC60596 |
H1L1A1B3
Featured
|
H1L1A1B3 is an ionizable lipid which demonstrates a fourfold increase in circRNA transfection efficiency in lung cancer cells over ALC-0315. H1L1A1B31 is capable of proactively stimulating innate immune activation upon injection. |
|
| DC66357 |
Sirtuin-1 inhibitor 1
Featured
|
Sirtuin-1 inhibitor 1 (Compound 8) is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases. |
|
| DC66358 |
Acid Red 4
Featured
|
Acid Red 4 is an azo dye. The wavelength of maximum absorbance for Acid Red 4 is 508 nm. |
|
| DC66359 |
UCCF-853
Featured
|
UCCF-853 is a CFTR modulator. |
|
| DC66360 |
CCR-11
Featured
|
CCR-11 is an antibacterial agent. CCR-11 can inhibit the proliferation of B. subtilis cells with an IC50 value of 1.2 μM. CCR-11 inhibits HeLa cell proliferation with an IC50 value of 18.1 μM. CCR-11 inhibits bacterial cytokinesis by inhibiting FtsZ assembly. CCR-11 can be used for the research of FtsZ-targeted antibacterial agents. |
|
| DC66361 |
mAChR antagonist 1
Featured
|
mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively. |
|
| DC66362 |
A3373
Featured
|
A3373, a novel chemical inhibitor of Phospholipase D1 (PLD1) and PLD2, with IC50 of 325 nM and 15.15?μM, respectively, inhibits LPS-induced immune response and plays important roles in autoimmune arthritis, bone demineralization and osteoclastogenesis. |
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| DC66363 |
MAO-B-IN-26
Featured
|
MAO-B-IN-26 (Compound IC9) is a MAO-B and acetylcholinesterase inhibitor. MAO-B-IN-26 protects SH?SY5Y cells against Aβ induced cytotoxicity, morphological changes, ROS generation and membrane damage. MAO-B-IN-26 also inhibits Aβ induced autophagy and apoptosis. MAO-B-IN-26 can be used as a neuroprotective agent against Alzheimer’s disease. |
|
| DC66364 |
STING-IN-7
Featured
|
STING-IN-7 (compound 21) is a potent STING inhibitor with an IC50 of 11.5 nM. STING-IN-7 inhibits the phosphorylation of STING and interferon regulatory factor 3 (IRF3). |
|
| DC66365 |
PP5-IN-1
Featured
|
PP5-IN-1 (Compound P053) is a competitive inhibitor of Serine/threonine protein phosphatase-5 (PP5) that binds to its catalytic domain and causes apoptosis in renal cancer. |
|
| DC66366 |
TNKS-2-IN-2
Featured
|
TNKS-2-IN-2 is a potent and selective inhibitor of TNKS2 with an IC50 of 22 nM. |
|
| DC66367 |
RORγ inverse agonist 1
Featured
|
RORγ inverse agonist 1 is the inverse agonist of RORγ. |
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